Zhijian Xu

Chinese Academy of Sciences

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Co-Authors

Weiliang Zhu

Shanghai Institute of Materia Medica

174

Xiaofeng Wang

Tsinghua University

Bo Li

Shanghai Institute of Materia Medica

Jujia Zhang

Chinese Academy of Sciences

Wenxiong Li

National University Hospital

Jumei Shi

Fujian University of Traditional Chinese Medicine

Lifan Wang

Purple Mountain Observatory

Zesheng Yang

Liming Rui

Tsinghua University

Yunxiang Lu

Dalian University of Technology

Cooperative Institutions

Chinese Academy of Sciences

425

University of Chinese Academy of Sciences

227

Shanghai Institute of Materia Medica

208

Chinese Academy of Medical Sciences & Peking Union Medical College

142

Shanghai Jiao Tong University

124

Fudan University

Zhejiang University

Sun Yat-sen University

Tongji University

Shanghai University of Traditional Chinese Medicine

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Force fields and scoring functions for carbohydrate simulation

Carbohydrate Research (2014)

Xiuming Xiong Zhaoqiang Chen Benjamin P. Cossins Zhijian Xu Qiang Shao

Force Field

10.1016/j.carres.2014.10.028

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Citations (56)

ChemInform Abstract: Discovery of N‐Substituted 3‐Arylisoquinolone Derivatives as Antitumor Agents Originating from O‐Substituted 3‐Arylisoquinolines via [2,3] or [3,3] Rearrangement.

ChemInform (2014)

Bo Li Gaihong Wang Zhijian Xu Yong Zhang X.-H. Huang

Abstract A variety of N‐substituted 3‐arylisoquinolone derivatives are synthesized via [2,3] or [3,3] rearrangement reactions of corresponding O‐substituted 3‐arylisoquinolines.

10.1002/chin.201439181

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H19/miR‐107/HMGB1 axis sensitizes laryngeal squamous cell carcinoma to cisplatin by suppressing autophagy in vitro and in vivo

Cell Biology International (2020)

Liwei Chen Zhijian Xu Jiandong Zhao Xingyou Zhai Jianhui Li

Abstract Laryngeal squamous cell carcinoma (LSCC) is the most common malignant tumor, which occurs in the head and neck. Current treatments for LSCC are all largely weakened by increasing drug resistance. Our study aimed to investigate the effects of long noncoding RNA (lncRNA) H19 on drug resistance in LSCC. In our study, we found that the level of H19 was sharply upregulated in LSCC tissues and drug‐resistant cells compared with the control. Besides, the expression of high‐mobility group B1 (HMGB1) was elevated, and microRNA107 (miR‐107) was suppressed in drug‐resistant cells compared with the control. Further study revealed that the interference of H19 by short hairpin RNA (shRNA) effectively suppressed high autophagy level and obvious drug resistance in drug‐resistant cells. Besides that, miR‐107 was predicted as a target of H19 and inhibiting effects of H19 shRNA on autophagy and drug resistance were both reversed by miR‐107 inhibitor. Moreover, HMGB1 was predicted as a target of miR‐107 in LSCC cells and knockdown of HMGB1 was able to suppress autophagy and drug resistance in LSCC cells. In addition, our investigation demonstrated that H19 shRNA exerted an inhibiting effect on autophagy and drug resistance by downregulating HMGB1 by targeting miR‐107. Finally, the in vivo experiment revealed that LV‐H19 shRNA strongly suppressed drug resistance compared with the usage of cisplatin individually. Taken together, our research indicated an H19–miR‐107–HMGB1 axis in regulating the autophagy‐induced drug resistance in LSCC in vitro and in vivo, providing novel targets for molecular‐targeted therapy and broadening the research for LSCC.

HMGB1

10.1002/cbin.11520

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Citations (37)

Pterostilbene Inhibits Human Multiple Myeloma Cells via ERK1/2 and JNK Pathway In Vitro and In Vivo

International Journal of Molecular Sciences (2016)

Bingqian Xie Zhijian Xu Liangning Hu Gege Chen Rong Wei

Multiple myeloma (MM) is the second most common malignancy in the hematologic system, which is characterized by accumulation of plasma cells in bone marrow. Pterostilbene (PTE) is a natural dimethylated analog of resveratrol, which has anti-oxidant, anti-inflammatory and anti-tumor properties. In the present study, we examined the anti-tumor effect of PTE on MM cell lines both in vitro and in vivo using the cell counting kit (CCK)-8, apoptosis assays, cell cycle analysis, reactive oxygen species (ROS) generation, JC-1 mitochondrial membrane potential assay, Western blotting and tumor xenograft models. The results demonstrated that PTE induces apoptosis in the H929 cell line and causes cell cycle arrest at G0/G1 phase by enhancing ROS generation and reducing mitochondrial membrane potential. The anti-tumor effect of PTE may be caused by the activation of the extracellular regulated protein kinases (ERK) 1/2 and c-Jun N-terminal kinase (JNK) signaling pathways. Additionally, mice treated with PTE by intraperitoneal injection demonstrated reduced tumor volume. Taken together, the results of this study indicate that the anti-tumor effect of PTE on MM cells may provide a new therapeutic option for MM patients.

Pterostilbene

10.3390/ijms17111927

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Citations (42)

LIGO/Virgo G270580: A third optical transient from CNEOST

GRB Coordinates Network (2017)

Haibin Zhao D. Xu Bin Li G. Zhaori Hao Lü

Transient (computer programming)

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Rational design and discovery of novel oxalate-like derivatives as aphid-repellent candidates based on odorant-binding protein 3

Journal of Molecular Structure (2023)

Ziwei Zhu Jianing Li Chong Liu Huilin Li Xingxing Lu

Rational design

10.1016/j.molstruc.2023.137336

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PTSS Transient Discovery Report for 2017-07-21

Transient Name Server Discovery Report (2017)

Zhijian Xu Bin Li Zhitong Li Wenxiong Li Xiaofeng Wang

Transient (computer programming)

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Synthesis and biological evaluation of multimodal monoaminergic arylpiperazine derivatives with potential antidepressant profile

European Journal of Medicinal Chemistry (2024)

Jiefang Zheng Liping Zhou Xudong Gong Feipu Yang Jiaxin Cheng

Monoaminergic

10.1016/j.ejmech.2024.116564

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Controlling the spin state of diphenylcarbene via halogen bonding: A theoretical study

International Journal of Quantum Chemistry (2018)

Ge Yang Yunxiang Lu Zhijian Xu Honglai Liu

Abstract Halogen bonding has recently become an effective tool to control the spin state of reactive carbenes. In this work, a series of the complexes of diphenylcarbene (DPC) that has a triplet ground state with several halogen bond donors RX were theoretically studied, and in particular, the influence of the formation of halogen bonding on the spin state of DPC was extensively explored. The spin flip depends on the difference of halogen bond energies between triplet and singlet, that is, when the difference is large enough a spin flip may occur. Furthermore, the variations of the geometries on complexation may induce the potential energy surfaces of different spin states to intersect, thus leading to intersystem crossing. Based on the energy analysis of the minimum energy crossing points (MECPs), the systems with a smaller MECP‐triplet energy barrier go through intersystem crossing more easily. Halogen bonds in the complexes, where a spin flip takes place, exhibit a partially covalent character, while other complexes show conventional behaviors of halogen bonding. According to charge decomposition analysis, the charge transfer from HOMO (DPC) to LUMO (RX) is identified as a prominent stabilizing interaction in the whole complexes.

Intersystem crossing

Halogen bond

Singlet fission

Spin states

10.1002/qua.25616

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Pterostilbene induces apoptosis and cell cycle arrest in diffuse large B-cell lymphoma cells

Scientific Reports (2016)

Yuanyuan Kong Gege Chen Zhijian Xu Guang Yang Bo Li

Abstract Diffuse large B-cell lymphoma (DLBCL) is the most common type of non-Hodgkin lymphoma (NHL). Pterostilbene, a natural dimethylated analog of resveratrol, has been shown to possess diverse pharmacological activities, including anti-inflammatory, antioxidant and anticancer properties. However, to the best of our knowledge, there has been no study of the effects of pterostilbene upon hematological malignancies. Herein, we report the antitumor activity and mechanism of pterostilbene against DLBCL cells both in vitro and in vivo . We found that pterostilbene treatment resulted in a dose-dependent inhibition of cell viability. In addition, pterostilbene exhibited a strong cytotoxic effect, as evidenced not only by reductions of mitochondrial membrane potential (MMP) but also by increases in cellular apoptotic index and reactive oxygen species (ROS) levels, leading to arrest in the S-phase of the cell cycle. Furthermore, pterostilbene treatment directly up-regulated p-p38MAPK and down-regulated p-ERK1/2. In vivo , intravenous administration of pterostilbene inhibited tumor development in xenograft mouse models. Overall, the results suggested that pterostilbene is a potential anti-cancer pharmaceutical against human DLBCL by a mechanism involving the suppression of ERK1/2 and activation of p38MAPK signaling pathways.

Pterostilbene

Viability assay

10.1038/srep37417

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Citations (63)