Abstract Uveal melanoma (UM) is a leading intraocular malignancy with a high 5‐year mortality rate, and radiotherapy is the primary approach for UM treatment. However, the elevated lactic acid, deficiency in ROS, and hypoxic tumor microenvironment have severely reduced the radiotherapy outcomes. Hence, this study devised a novel CoMnFe‐layered double oxides (LDO) nanosheet with multienzyme activities for UM radiotherapy enhancement. On one hand, LDO nanozyme can catalyze hydrogen peroxide (H 2 O 2 ) in the tumor microenvironment into oxygen and reactive oxygen species (ROS), significantly boosting ROS production during radiotherapy. Simultaneously, LDO efficiently scavenged lactic acid, thereby impeding the DNA and protein repair in tumor cells to synergistically enhance the effect of radiotherapy. Moreover, density functional theory (DFT) calculations decoded the transformation pathway from lactic to pyruvic acid, elucidating a previously unexplored facet of nanozyme activity. The introduction of this innovative nanomaterial paves the way for a novel, targeted, and highly effective therapeutic approach, offering new avenues for the management of UM and other cancer types.

Hypoxia

10.1002/advs.202403107

Cite

Citations (7)

Synthesis of biocompatible AuAgS/Ag2S nanoclusters and their applications in photocatalysis and mercury detection

Journal of Nanoparticle Research (2014)

Qian Zhao Shenna Chen Lingyang Zhang Haowen Huang Fengping Liu

Nanoclusters

Mercury

Photodegradation

Biocompatibility

10.1007/s11051-014-2793-4

Cite

Citations (10)

Antibacterial Property and Biocompatibility of Polypyrrole Films Treated by Oxygen Plasma Immersion Ion Implantation

Advanced Materials Interfaces (2020)

Xiaoou Li Jiajun Qiu Xuanyong Liu

Abstract Polypyrrole (PPy) films obtained by oxidative polymerization have positive charges in its main chains and therefore exhibit antibacterial properties to some extent. However, antibacterial activities of PPy films for biomedical applications are still insufficient. Here, to endow PPy films with excellent antibacterial properties and biocompatibility, oxygen plasma immersion ion implantation (O‐PIII) is performed to regulate their physicochemical properties, including but not limited to wettability and surface charge. Escherichia coli , Staphylococcus aureus , and MC3T3‐E1 cells are utilized to investigate the antibacterial properties and cytocompatibility, respectively. Results show that antibacterial property of PPy films against E. coli is enhanced after O‐PIII treatment, and it becomes more outstanding with the increase of implantation time, which may be ascribed to the improved hydrophilicity and change of sample surfaces from negatively charged to positively charged. The similar results cannot be found from S. aureus due to different cell membrane structure. Meanwhile, O‐PIII can significantly improve the biocompatibility of PPy films.

Biocompatibility

Polypyrrole

Plasma-immersion ion implantation

10.1002/admi.202000057

Cite

Citations (15)

A Quantitative Bacteria Monitoring and Killing Platform Based on Electron Transfer from Bacteria to a Semiconductor

Advanced Materials (2020)

Guomin Wang Kaiwei Tang Zheyi Meng Pei Liu Shi Mo

Abstract A platform with both bacteria killing and sensing capabilities is crucial for monitoring the entire bacteria‐related process on biomaterials and biomedical devices. Electron transfer (ET) between the bacteria and a Au‐loaded semiconductor (ZnO) is observed to be the primary factor for effective bacteria sensing and fast bacteria killing. The electrons produce a saturation current that varies linearly with the bacteria number, semi‐logarithmically, with R 2 of 0.98825, thus providing an excellent tool to count bacteria quantitatively in real‐time. Furthermore, ET leads to continuous electron loss killing of about 80% of Escherichia coli in only 1 h without light. The modularity and extendability of this ET‐based platform are also demonstrated by the excellent results obtained from other semiconductor/substrate systems and the stability is confirmed by recycling tests. The underlying mechanism for the dual functions is not due to conventional attributed Zn 2+ leaching or photocatalysis but instead electrical interactions upon direct contact. The results reveal the capability of real‐time detection of bacteria based on ET while providing information about the antibacterial behavior of ZnO‐based materials especially in the early stage. The concept can be readily incorporated into the design of smart and miniaturized devices that can sense and kill bacteria simultaneously.

10.1002/adma.202003616

Cite

Citations (52)

Silver-nanoparticles-modified biomaterial surface resistant to staphylococcus: new insight into the antimicrobial action of silver

Scientific Reports (2016)

Jiaxing Wang Jinhua Li Geyong Guo Qiaojie Wang Jin Tang

Abstract Titanium implants are widely used clinically, but postoperative implant infection remains a potential severe complication. The purpose of this study was to investigate the antibacterial activity of nano-silver(Ag)-functionalized Ti surfaces against epidemic Staphylococcus from the perspective of the regulation of biofilm-related genes and based on a bacteria-cell co-culture study. To achieve this goal, two representative epidemic Staphylococcus strains, Staphylococcus epidermidis ( S. epidermidis , RP62A) and Staphylococcus aureus ( S. aureus , USA 300), were used, and it was found that an Ag-nanoparticle-modified Ti surface could regulate the expression levels of biofilm-related genes ( ica A and ica R for S. epidermidis ; fnb A and fnb B for S. aureus ) to inhibit bacterial adhesion and biofilm formation. Moreover, a novel bacteria-fibroblast co-culture study revealed that the incorporation of Ag nanoparticles on such a surface can help mammalian cells to survive, adhere and spread more successfully than Staphylococcus . Therefore, the modified surface was demonstrated to possess a good anti-infective capability against both sessile bacteria and planktonic bacteria through synergy between the effects of Ag nanoparticles and ion release. This work provides new insight into the antimicrobial action and mechanism of Ag-nanoparticle-functionalized Ti surfaces with bacteria-killing and cell-assisting capabilities and paves the way towards better satisfying the clinical needs.

Silver nanoparticle

10.1038/srep32699

Cite

Citations (122)