Ningjie Chen

Emory University

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Diana H. Chai

Merrimack Pharmaceuticals (United States)

Haitao Wang

Southern Medical University

L S Brown

Emory University

Siqing Wang

West China Hospital of Sichuan University

Shuang Yan

Harbin Medical University

Marilyn Owens

Thomas Jefferson University Hospital

Shengyao Fu

Zhongda Hospital Southeast University

James D. Fortenberry

Indiana University School of Medicine

Qingpeng Xu

Heilongjiang Bayi Agricultural University

Jincun Yang

Weihai Municipal Hospital

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Emory University

Shandong University

Fourth Affiliated Hospital of Harbin Medical University

Harbin Medical University

Children's Healthcare of Atlanta

Merrimack Pharmaceuticals (United States)

Massachusetts Institute of Technology

Howard Hughes Medical Institute

Lawrence Berkeley National Laboratory

University of California, Berkeley

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GO/Alg/PRP Regulates Oxidative Stress Through the p38MAPK/NF-κB Pathway on Ischemic Reperfusion Pressure Injury in Mice

Shuang Yan Siqing Wang Ningjie Chen Diana H. Chai Haitao Wang

Pressure Injury（PI） are localized damages to the skin or underlying soft tissues typically caused by intense and/or prolonged pressure, shearing, friction, or combination of these factors. The wound is difficult to heal and easily leads to infection and other complications. The repair of PI has become a global health problem. This paper describes the preparation and characterization of Graphene Oxide (GO)/Alginate (Alg) gel-loaded Platelet-Rich Plasma (PRP), and the effects of GO/Alg/PRP on cell proliferation and angiogenesis have been evaluated by cell experiments. The effects of GO/Alg/PRP on the Ischemic Reperfusion (I/R) model in mice were evaluated in animal experiments, and the relationship between oxidative stress and p38 Mitogen-Activated Protein Kinase (P38MAPK)/ Nuclear Factor-κB (NF-κB) pathway was investigated. GO/Alg, PRP and GO/Alg/PRP all promote cell proliferation, migration, angiogenesis, wound healing, collagen deposition and epithelial regeneration, and reduce oxidative stress damage of cells and tissues. Among these, GO/Alg/PRP plays the most significant role. We also found a relationship between oxidative stress and the p38MAPK/NF-κB pathway. Our findings suggest that GO/Alg/PRP could be an effective strategy for the treatment of I/R injuries and may serve as a basis for the development of novel PRP based bioactive wound dressings.

Ischemic reperfusion injury

10.20944/preprints202501.1156.v2

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S-NITROSOGLUTATHIONE INHIBITS ACTIVATION OF TRANSCRIPTION FACTOR NFκB IN HUMAN NEUTROPHILS (PMNS) • 182

Pediatric Research (1997)

James D. Fortenberry Marilyn Owens Ningjie Chen L S Brown

Proinflammatory cytokine

S-Nitrosoglutathione

Viability assay

IκBα

10.1203/00006450-199704001-00202

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Citations (1)