Sunggyun Park

Keimyung University

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Nam Hee Ryoo

Keimyung University

Jung‐Sook Ha

Keimyung University

Seung‐Tae Lee

Yonsei University

Do‐Hoon Kim

Keimyung University

Dong‐Seok Jeon

Keimyung University

Jae Hee Lee

Kyungpook National University Hospital

Soon Hee Chang

Kyungpook National University Hospital

Sang-Gyung Kim

Catholic University of Daegu

Kyoung Bo Kim

Keimyung University

Ji Yeon Ham

Kyungpook National University Hospital

Cooperative Institutions

Yonsei University

Keimyung University

Seoul National University

Keimyung University Dongsan Medical Center

Severance Hospital

Sungkyunkwan University

Kyungpook National University

Seoul National University Hospital

Seoul National University Bundang Hospital

New Generation University College

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Three Cases of False-positive Multiplex Ligation-dependent Probe Amplification of BRCA1

Annals of Laboratory Medicine (2022)

Kyoung Bo Kim Sunggyun Park Jung‐Sook Ha Nam Hee Ryoo Do‐Hoon Kim

Multiplex

10.3343/alm.2022.42.4.497

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Citations (2)

Pregnancy Outcome, Antibodies, and Placental Pathology in SARS-CoV-2 Infection during Early Pregnancy

International Journal of Environmental Research and Public Health (2021)

Won-Kyu Jang Su‐Yeon Lee Sunggyun Park Nam Hee Ryoo Ilseon Hwang

There are reports that pregnant women infected with SARS-CoV-2 not only have increased morbidity but also increased complications and evidence of maternal and fetal vascular malperfusion on placental pathology. This was a retrospective study of pregnant women diagnosed with SARS-CoV-2 infection after March 2020. The results of reverse transcription polymerase chain reaction testing and IgM and IgG antibody testing of the amniotic fluid, cord blood, placenta, and maternal blood were confirmed at delivery. Placentas were evaluated histopathologically. The study included seven pregnant women diagnosed with SARS-CoV-2 infection during pregnancy at a mean gestational age of 14.5 weeks. Out of the seven women, five were infected during the first trimester. The mean gestational age at delivery was 38.4 weeks. The reverse transcription polymerase chain reaction results for maternal plasma, cord blood, placenta, and amniotic fluid were negative and IgG antibodies were detected in maternal plasma and cord blood. On placental pathology, maternal vascular malperfusion was found in only one case, fetal vascular malperfusion in four cases, and inflammatory changes were found in two cases. Pregnancy outcomes for women diagnosed with SARS-CoV-2 infection during early pregnancy are positive and it is likely that maternal antibodies are passed to the fetus, which results in a period of immunity.

Cord blood

10.3390/ijerph18115709

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Citations (16)

Author Correction: Analysis of BRCA1/2 variants of unknown significance in the prospective Korean Hereditary Breast Cancer study

Scientific Reports (2023)

Joo Heung Kim Sunggyun Park Hyung Seok Park Ji Soo Park Seung‐Tae Lee

10.1038/s41598-023-31093-x

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Validation of the Accuracy of Automatic Measurement of Blood Volume in Culture Bottles for Blood Culture

Diagnostics (2023)

Kyoung Bo Kim Sunggyun Park

Several manufacturers have developed systems that automatically measure the amount of blood in culture bottles. We compared the volumes measured automatically by the Virtuo instrument (bioMérieux, France) (height-based volumes) and those calculated by weighing the bottles. In all, 150 pairs of aerobic and anaerobic blood culture bottles (BacT/ALERT FA/FN Plus, bioMérieux) were randomly selected over two periods to compare the height- and weight-based volumes and analyze the effect of foam. We also estimated the limit of detection (LOD) and the cut-off value for 5 mL equine blood. The mean height-based volume was approximately 0.67 mL greater than the weight-based volume, particularly in anaerobic culture bottles. Foam did not have a significant effect. The LOD for the automatic height-based volume of equine blood was 0.2-0.4 mL. The 5 mL cut-off was 4-4.2 mL. Therefore, when reporting or monitoring blood volume within culture bottles in the laboratory, these performance characteristics should be adequately considered.

Blood Culture

Human blood

10.3390/diagnostics13162685

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Experience in the Department of Diagnostic Laboratory Medicine at a University Hospital in Daegu During the COVID-19 Pandemic

Advances in Precision Medicine (2023)

Sunggyun Park Do‐Hoon Kim Won-Mok Lee Jung‐Sook Ha Dong‐Seok Jeon

The first case of coronavirus disease 2019 (COVID-19) in Korea was reported in January 2020. As the secondary transmissions accelerated within the country, the government revised the outbreak alert for COVID-19 from attention to caution. Mid-February, when a massive outbreak was reported from a church in Daegu, our institution initiated testing for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). More than 300 laboratory tests were performed within the first 2 months before the number of cases began to decline. Here, we describe our experience of 4 months at the Department of Laboratory Medicine, Keimyung University Dongsan Hospital, located in Daegu,where a massive COVID-19 outbreak occurred.

Pandemic

2019-20 coronavirus outbreak

10.18063/apm.v6i2.236

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Serological Evaluation of Patients with Coronavirus Disease-2019 in Daegu, South Korea

SSRN Electronic Journal (2020)

Sunggyun Park Soon Hee Chang Jae Hee Lee Jong Ho Lee Ji Yeon Ham

Background: Early and accurate detection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is critical to prevent spread of the infection. Understanding of the antibody response to SARS-CoV-2 in patients with coronavirus disease 2019 (COVID-19) is insufficient, particularly in relation to those whose responses persist for more than 1 month after the onset of symptoms. We conducted a SARS-CoV-2 antibody test to identify factors affecting the serological response and to evaluate its diagnostic utility in patients with COVID-19.Methods: We collected 1,048 residual serum samples from 396 patients with COVID-19 confirmed by real-time reverse transcription polymerase chain reaction (RT-PCR) for SARS-CoV-2. The samples had been used for routine admission tests in six healthcare institutions in Daegu. Antibody to SARS-CoV-2 was analyzed and the cutoff index (COI) was calculated for quantitative analysis. The patients' information was reviewed to evaluate the relationship between antibody positivity and clinical characteristics.Findings: The anti-SARS-CoV-2 antibody positivity rate was 85% and the average COI was 24·3. The positivity rate and COI increased with time elapsed since symptom onset. Anti-SARS-CoV-2 antibody persisted for at least 13 weeks after symptom onset at a high COI. There was a significant difference in anti-SARS-CoV-2 antibody positivity rate between patients with and without symptoms, but not according to sex or disease course. The descending COI pattern at weeks 1 to 5 after symptom onset was significantly more frequent in patients who died than in those who recovered. There was a correlation between anti-SARS-CoV-2 antibody positivity and the cycle threshold value of RdRP by real-time RT-PCR.Interpretation: Anti-SARS-CoV-2 antibody persisted for at least 13 weeks at a high COI in patients with COVID-19. A decreasing COI pattern up to fifth week may be associated with a poor prognosis of COVID-19. As new treatments and vaccines are introduced, it is important to monitor continuously the usefulness of anti-SARS-CoV-2 antibody assays.Funding Statement: Research Program funded by the Korea Centers for Disease Control and Prevention (2020ER551000).Declaration of Interests: All authors declare no competing interests.Ethics Approval Statement: The study protocol was reviewed and approved by the Institutional Review Board of Medicity Daegu Joint (approval no. DGIRB 2020-05-009-003).

Coronavirus

2019-20 coronavirus outbreak

Pandemic

10.2139/ssrn.3754806

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Contents of Chemical Constituents in Organic Korean Cabbages

Korean Journal of Food Preservation (2006)

Jong-Hwan Seong Sunggyun Park Eun-Mi Park Hansoo Kim Dong‐Seob Kim

To evaluate the chemical characteristics of organic Korean cabbages, the content of moisture, crude protein, crude lipid, crude ash, dietary fiber, mineral, vitamin C, free sugar, organic acid, chlorophyll and carotenoid were analyzed in organic and nonorganic cabbages. The levels of crude protein, crude lipid, crude ash, soluble dietary fiber, insoluble dietary fiber, minerals(Ca, P, Ee, Mg, S, Zn), ascorbic acid, dehydroascorbic acid, fructose, glucose, sucrose, chlorophyll a, chlorophyll b and carotenoid in organic cabbages were higher than those in nonorganic cabbages. However, the content of moisture, malic acid, citric acid, potassium in organic cabbages were lower than those in nonorganic cabbages.

Dehydroascorbic acid

Organic acid

Malic acid

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Citations (17)

Serological evaluation of patients with coronavirus disease-2019 in Daegu, South Korea

PLoS ONE (2022)

Sunggyun Park Soon Hee Chang Jae Hee Lee Jong Ho Lee Ji Yeon Ham

Background Early and accurate detection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is critical to prevent spread of the infection. Understanding of the antibody response to SARS-CoV-2 in patients with coronavirus disease 2019 (COVID-19) is insufficient, particularly in relation to those whose responses persist for more than 1 month after the onset of symptoms. We conducted a SARS-CoV-2 antibody test to identify factors affecting the serological response and to evaluate its diagnostic utility in patients with COVID-19. Methods and finding We collected 1,048 residual serum samples from 396 patients with COVID-19 confirmed by real-time reverse transcription polymerase chain reaction (RT-PCR) for SARS-CoV-2. The samples had been used for routine admission tests in six healthcare institutions in Daegu. Antibody to SARS-CoV-2 was analyzed and the cutoff index (COI) was calculated for quantitative analysis. The patients’ information was reviewed to evaluate the relationship between antibody positivity and clinical characteristics. The anti-SARS-CoV-2 antibody positivity rate was 85% and the average COI was 24·3. The positivity rate and COI increased with time elapsed since symptom onset. Anti-SARS-CoV-2 antibody persisted for at least 13 weeks after symptom onset at a high COI. There was a significant difference in anti-SARS-CoV-2 antibody positivity rate between patients with and without symptoms, but not according to sex or disease course. The descending COI pattern at weeks 1 to 5 after symptom onset was significantly more frequent in patients who died than in those who recovered. Conclusions Anti-SARS-CoV-2 antibody persisted for at least 13 weeks at a high COI in patients with COVID-19. A decreasing COI pattern up to fifth week may be associated with a poor prognosis of COVID-19. As new treatments and vaccines are introduced, it is important to monitor continuously the usefulness of anti-SARS-CoV-2 antibody assays.

Coronavirus

10.1371/journal.pone.0262820

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Citations (2)

Viral load and rebound in children with coronavirus disease 2019 during the first outbreak in Daegu city

Clinical and Experimental Pediatrics (2021)

Mi Ae Chu Yoon Young Jang Dong Won Lee Sung Hoon Kim Nam Hee Ryoo

Viral load and shedding duration are highly associated with the transmission of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection. However, limited studies have reported on viral load or shedding in children and adolescents infected with sudden acute respiratory syndrome coronavirus 2 (SARS-CoV-2).This study aimed to investigate the natural course of viral load in asymptomatic or mild pediatric cases.Thirty-one children (<18 years) with confirmed SARS-CoV-2 infection were hospitalized and enrolled in this study. Viral loads were evaluated in nasopharyngeal swab samples using real-time reverse transcription polymerase chain reaction (E, RdRp, N genes). cycle threshold (Ct) values were measured when patients met the clinical criteria to be released from quarantine.The mean age of the patients was 9.8 years, 18 (58%) had mild disease, and 13 (42%) were asymptomatic. Most children were infected by adult family members, most commonly by their mothers. The most common symptoms were fever and sputum (26%), followed by cough and runny nose. Nine patients (29%) had a high or intermediate viral load (Ct value≤30) when they had no clinical symptoms. Viral load showed no difference between symptomatic and asymptomatic patients. Viral rebounds were found in 15 cases (48%), which contributed to prolonged viral detection. The mean duration of viral detection was 25.6 days. Viral loads were significantly lower in patients with viral rebounds than in those with no rebound (E, P=0.003; RdRp, P=0.01; N, P=0.02).Our study showed that many pediatric patients with coronavirus disease 2019 (COVID-19) experienced viral rebound and showed viral detection for more than 3 weeks. Further studies are needed to investigate the relationship between viral rebound and infectiousness in COVID-19.

Viral Shedding

Coronavirus

10.3345/cep.2020.02033

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Experience at Department of Laboratory Medicine during the COVID-19 Outbreak in Daegu

Annals of Clinical Microbiology (2020)

Sunggyun Park Do‐Hoon Kim Won-Mok Lee Jung‐Sook Ha Dong‐Seok Jeon

The first case of coronavirus disease 2019 (COVID-19) in Korea was reported in January 2020. As the secondary transmissions accelerated within the country, the government revised the outbreak alert for COVID-19 from attention to caution. Mid-February, when a massive outbreak was reported from a church in Daegu, our institution initiated testing for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). More than 300 laboratory tests were performed within the first 2 months, before the number of cases began to decline. Here, we describe our experience of 4 months at the department of Laboratory Medicine, Keimyung University Dongsan Hospital, located in Daegu, where a massive COVID-19 outbreak occurred.

2019-20 coronavirus outbreak

10.5145/acm.2020.23.4.1

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