Yuan Zhou

Capital Medical University

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Kun Zou

Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine

Fan Cheng

Guangdong Medical College

Junzhi Wang

China Three Gorges University

Dongrui Deng

Guiyang Medical University

Fanfan Li

First Hospital of Lanzhou University

Mengzhou He

Tongji Hospital

Jun Wu

Institute of Zoology

Zhiyong Guo

Fourth Hospital of Hebei Medical University

Meitao Yang

Wuhan University

Jun Wu

New Generation University College

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Capital Medical University

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Beijing Anzhen Hospital

Huazhong University of Science and Technology

Chinese Academy of Medical Sciences & Peking Union Medical College

Capital University

Peking University

Shanghai Jiao Tong University

Wuhan University

Chinese Academy of Sciences

Chongqing University

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Impaired Gal-9 Dysregulates the PBMC-Induced Th1/Th2 Imbalance in Abortion-Prone Matings

Journal of Immunology Research (2018)

Mengzhou He Ming Jiang Yuan Zhou Fanfan Li Meitao Yang

Recurrent miscarriage is defined as the loss of 3 or more consecutive pregnancies; however, the underlying immunologic mechanisms that trigger pregnancy loss remain largely unelucidated. Galectin-9 (Gal-9) may modulate a variety of biologic functions and play an important role in Th1/Th2 immune deviation. To analyze the mechanism of Gal-9 in abortion, we used the classical abortion-prone mouse model (DBA/2-mated CBA/J mice) to detect the expression of Gal-9 at the maternal-fetal interface. We also mimicked the immune environment of pregnancy by culturing trophoblast cells with peripheral blood mononuclear cells (PBMCs) to explore how Gal-9 might be involved in the pathogenesis of abortion. We found that the expression levels of Gal-9 in abortion-prone matings were lower than that for controls. Using a coculture system, we detected a Th1 preponderance in the coculture from abortion-prone matings. Furthermore, Gal-9 blockade augmented the imbalance of Th1/Th2 immunity in abortion-prone matings by promoting the secretion of Th1-derived cytokines in coculture, while there was a Th2 preponderance when we administered recombinant Gal-9. In conclusion, our results suggest that the Gal-9 signal is important for the regulation of PBMC function toward a Th2 bias at the maternal-fetal interface, which is beneficial for the maintenance of a normal pregnancy.

Trophoblast

Pathogenesis

10.1155/2018/9517842

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Citations (19)

Increased Toll-Like Receptor-Myeloid Differentiation Factor 88 Expression at the Maternal-Fetal Interface Is Associated with Spontaneous Abortion

Gynecologic and Obstetric Investigation (2017)

Mengzhou He Yuan Zhou Min Jiang Fanfan Li Meitao Yang

Toll-like receptors (TLRs) form a group of pattern recognition receptors that play a major role in maintaining innate host immunity. Myeloid differentiation factor 88 (MyD88) is an adaptor molecule that is essential for signaling via the TLR family. To analyze the mechanism of the imbalance in the innate immune system mediated by TLRs-MyD88 in spontaneous abortion, we detected the expression of TLR-2, TLR-4, TLR-7, and MyD88 in placentae and deciduas.The expression of TLR-2, TLR-4, TLR-7, and MyD88 in the placentae and deciduas of abortion-prone mice (n = 10) and normal pregnant mice (n = 10) were analyzed by immunochemistry, western blot, and real-time polymerase chain reaction.There were higher protein expression levels of TLR-2, TLR-4, TLR-7, and MyD88 in the placentae and deciduas in the abortion-prone group than in the normal pregnant group. However, TLR-2, TLR-4, and TLR-7 showed lower gene expression, while MyD88 manifested higher gene expression in placentae and deciduas of abortion-prone mice matings.TLR-2, TLR-4, TLR-7, and MyD88 were expressed in the placenta and decidua of both the abortion-prone pregnant and normal pregnant mice. The overexpression of TLRs may excessively activate the innate immune system mediated by MyD88, which is considered to be related to the pathogenesis of spontaneous abortion.

10.1159/000468931

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Citations (5)

[Short-term and long-term outcomes of tricuspid valve replacement in patients with left ventricular dysfunction].

Chung-Hua Wai K'o Tsa Chih (2021)

Kun Hua Mingyang Zhou Liang Zhang Yuan Zhou Zhan Peng

To examine the short-term and long-term outcomes of tricuspid valve replacement (TVR) in patients with left ventricular dysfunction.

EuroSCORE

10.3760/cma.j.cn112139-20200302-00176

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The benefit of fibrosa layer stripping technique during minimally invasive aortic valve replacement for calcified aortic valve stenosis—A randomized controlled trial

Journal of Cardiac Surgery (2020)

Yuan Zhou Liang Zhang Kun Hua Jinwei Zhang Xiubin Yang

Background Fibrosa layer stripping (FLS) technique is a new approach to remove the calcified aortic valve. In this study, we aimed to assess the effectiveness of the FLS technique by comparing it with the conventional technique in minimally invasive aortic valve replacement (MIAVR). Methods A prospective, single-center, randomized controlled trial was conducted at Beijing Anzhen Hospital. Seventy patients diagnosed with severe calcific aortic stenosis were randomly assigned to undergo FLS (n = 35) or conventional (n = 35) technique to debride calcified aortic valve. Preoperative profile, procedural parameters, and postoperative outcomes were analyzed. Results No significant difference was observed in the preoperative profile between the two groups. Compared with the conventional technique, the FLS technique had a significantly higher indexed effective orifice area and lower mean gradient. Moreover, the FLS technique was associated with significantly reduced aortic cross-clamp time (41 [38–44] vs. 56 [51-60] min, p < .001), cardiopulmonary bypass (CPB) time (63 [56–69] vs. 81 [75–84] min, p < .001), and operative time (148 [141–156] vs. 173 [169–180] min, p < .001). Lastly, the length of intensive care unit stay (1.2 ± 0.4 vs. 1.5 ± 0.8 days, p = .041) and hospital stay (5.3 ± 0.6 vs. 6.0 ± 1.4 days, p = .020) was significantly reduced in the FLS group compared with those in the conventional group. Conclusions FLS technique is effective in removing calcified tissue during MIAVR and is associated with shorter cross-clamp time and CPB time, and better hemodynamic performance than the conventional technique.

10.1111/jocs.15215

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Relationship between Leukoaraiosis and Atherosclerosis Plaques

Journal of Hard Tissue Biology (2014)

Zhao Xiao-hui Yuan Zhou Yuping Zhu Chen Juan Qingke Bai

The aim of this study was to investigate the relationship between the different kinds of leukoaraiosis (LA) and carotid atherosclerosis (AS) plaques. A total of 208 LA patients were divided into three groups, namely, circumventricular (Group I, n=68), subcortex (Group II, n=66), and mixed types (Group III, n=74). The AS plaques and stenosis of the carotid were detected using color Doppler flow imaging and the magnetic resonance images of patients, respectively. Among the patients enrolled in this study, 67.79% (141/208) had AS plaques, 24.04% of which was detected in Group II (50/66), 25.96% from Group III (54/74), and 17.79% from Group I (37/68), with significant difference among all groups. By contrast, the score of the stable plaques was identical, with all the AS plaques scoring under three grades. The Grades I/II/III plaques of the subjects in Group I were 45/40/47, respectively; Group II had 20/40/47; and Group III had 20/31/34. The Grades I/II/III plaques among the 52 subjects with cortid stenosis (50%) were 15/19/18 without any differences. The carotid AS plaque is one of the risk factors of LA and the fragments of vulnerable plaques related to leukoaraiosis.

Leukoaraiosis

Color doppler

10.2485/jhtb.23.205

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New furostanol saponins from the rhizomes ofTupistra chinensis

Natural Product Research (2012)

Cheng‐Xiong Liu Zhiyong Guo Zhangshuang Deng Yanhong Xue Kun Zou

Abstract Three new furostanol saponins (1–3), including a polyhydroxyl saponin, were isolated from the rhizomes of Tupistra chinensis. The structures of these compounds were identified by NMR, MS spectral data and chemical methods. Keywords: Tupistra chinensis furostanol saponinNMRstructural elucidation Acknowledgements Financial support for this work from the National Natural Science Foundations of China (30870254) and Innovation Team Program of Natural Science Foundations of Hubei Province (2007ABC008) is gratefully acknowledged.

Spectral Analysis

Chemical structure

10.1080/14786419.2012.660637

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Citations (10)

Xylogranatins A—D, New Mexicanolides from the Fruit of a Chinese Mangrove Xylocarpus granatum.

ChemInform (2007)

Jun Wu Si Zhang Min‐Yi Li Yuan Zhou Qiang Xiao

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.

10.1002/chin.200717174

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[Determination of chlorogenic acid and eriodictyol-7-O-beta-D-glucuronide in Pyrrosia by RP-HPLC].

PubMed (2003)

Chen Ma Yuan Zhou Liu Ai-ru

To develop a method for determination of chlorogenic acid and eriodictyol-7-O-beta-D-glucuronide in Pyrrosia of different species and different places of origin by RP-HPLC.Chromatography was performed using a C18 column with mobile phase of methanol-water-phosphoric acid (50:200:0.2). The monitoring wavelength was 284 nm.The linear ranges were 0.01-5.0 micrograms (r = 0.9997) and 0.004-5.0 micrograms (r = 0.9997), the recoveries were 97.1% (n = 8, RSD = 2.7%) and 98.8% (n = 9, RSD = 2.5%) for chlorogenic acid and eriodictyol-7-O-beta-D-glucuronide, respectively.The method was employed to the analysis of 21 samples of Pyrrosia. The contents of compounds vary greatly depending on the species used, place of collection and time of harvesting. The HPLC method is sensitive, rapid and can be used to control the quality of Pyrrosia and to guide reasonable season of harvesting.

Chlorogenic Acid

Phosphoric acid

Eriodictyol

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Trop2 plays a cardioprotective role by promoting cardiac c-kit+ cell proliferation and inhibition of apoptosis in the acute phase of myocardial infarction

International Journal of Molecular Medicine (2013)

Jianye Yang Yuan Zhou Bo Liu Hongfei Wang Xinling Du

Trop2 is a cell-surface glycoprotein associated with epithelial carcinomas. Although recent studies indicated that Trop2 is expressed in some stem-like cells, the molecular function of the protein remains largely unknown. In the present study, we observed that acute phase myocardial infarction (MI) induced an increase of c-kit+/Trop2+ cells and found that Trop2 enhanced cardiac c-kit+ cell survival and proliferation via its antiapoptotic activity, due to an elevated activity of ribosomal S6 kinases in the mitogen-activated protein kinase pathway. This study provides insight into better understanding the molecular function of Trop2, which could serve as a potential target for the treatment of MI.

10.3892/ijmm.2013.1332

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Relationship between coronary artery calcification and calcium deposition in the myocardium

Journal of International Medical Research (2019)

Yue Wang Yucai Hu Yuan Zhou Lei Zhao Dong Chen

Objectives To investigate the relationship between coronary artery calcification and calcium deposition in cardiomyocytes. Methods Patients who underwent valve replacement plus surgical ablation for atrial fibrillation, together with left atrial appendage resection, were included. Coronary artery calcification (CAC) score was evaluated prior to surgery using dual-source computed tomography. Samples of left atrial appendage tissue were collected to analyse the following indicators: calcium deposition, alkaline phosphatase activity, calcium content, protein levels of runt-related transcription factor 2 (Runx2), osteopontin and β-catenin, and mRNA levels of osteopontin, endothelin and ghrelin. Relationships between CAC score and various indicators were analysed by univariate logistic or linear regression. Results Out of tissue from eight patients, CAC score was not correlated with cardiomyocyte calcification (odds ratio [OR] 0.984 and OR 0.983; von Kossa or alizarin red staining, respectively). CAC score showed an inverse linear correlation with Runx2 protein (β = –0.75), but was not correlated with osteopontin (β = –0.52) or β-catenin protein (β = –0.56), mRNA levels of osteopontin, endothelin and ghrelin (β = 0.13, 0.02, and 0.02, respectively), alkaline phosphatase activity (β = 0.56), or calcium content (β = –0.22). Conclusions Coronary artery calcification was not correlated with calcium deposition in cardiomyocytes.

Osteopontin

RUNX2

Von Kossa stain

10.1177/0300060519848587

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Citations (2)