Daniele C. Aguiar

Universidade Federal de Minas Gerais

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Fabrício A. Moreira

Universidade Federal de Minas Gerais

Francisco Silveira Guimarães

Universidade de São Paulo

Pedro H. Gobira

Aarhus University

Ana Luisa B. Terzian

Universidade de São Paulo

Ana F. Almeida‐Santos

Universidade Federal de Minas Gerais

Leonardo B.M. Resstel

Universidade de São Paulo

Thércia Guedes Viana

Institut des Sciences Biologiques

Igor Dimitri Gama Duarte

Universidade Federal de Minas Gerais

Thiago Roberto Lima Romero

Universidade Federal de Minas Gerais

Carsten T. Wotjak

Max Planck Institute of Psychiatry

Cooperative Institutions

Universidade Federal de Minas Gerais

Universidade de São Paulo

Universidade de Ribeirão Preto

Clinics Hospital of Ribeirão Preto

National Council for Scientific and Technological Development

Institut des Sciences Biologiques

Universidad Complutense de Madrid

Universidade Federal do Espírito Santo

Universidade Brasil

Fundação de Amparo à Pesquisa do Estado de São Paulo

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High-refined carbohydrate containing diet induces anxiety-like behavior through nitric oxide pathway

European Neuropsychopharmacology (2016)

Daniele C. Aguiar J.S. Gomes Virgínia Lúcia Fontes Soares João Manoel de Oliveira Silva A.V. Ferreira

10.1016/s0924-977x(16)31672-8

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Citations (1)

Animal models for predicting the efficacy and side effects of antipsychotic drugs

Brazilian Journal of Psychiatry (2013)

Pedro H. Gobira Jivago Röpke Daniele C. Aguiar J.A.S. Crippa Fabrício A. Moreira

The use of antipsychotic drugs represents an important approach for the treatment of schizophrenia. However, their efficacy is limited to certain symptoms of this disorder, and they induce serious side effects. As a result, there is a strong demand for the development of new drugs, which depends on reliable animal models for pharmacological characterization. The present review discusses the face, construct, and predictive validity of classical animal models for studying the efficacy and side effects of compounds for the treatment of schizophrenia. These models are based on the properties of antipsychotics to impair the conditioned avoidance response and reverse certain behavioral changes induced by psychotomimetic drugs, such as stereotypies, hyperlocomotion, and deficit in prepulse inhibition of the startle response. Other tests, which are not specific to schizophrenia, may predict drug effects on negative and cognitive symptoms, such as deficits in social interaction and memory impairment. Regarding motor side effects, the catalepsy test predicts the liability of a drug to induce Parkinson-like syndrome, whereas vacuous chewing movements predict the liability to induce dyskinesia after chronic treatment. Despite certain limitations, these models may contribute to the development of more safe and efficacious antipsychotic drugs.

Psychotomimetic

Catalepsy

10.1590/1516-4446-2013-1164

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Citations (53)

Dysbiotic oral microbiota contributes to alveolar bone loss associated with obesity in mice

Journal of Applied Oral Science (2022)

Ian de Meira Chaves Marina Campos Zicker Alice de Oliveira Laranjeira Ana Letícia Malheiros Silveira Daniele C. Aguiar

Periodontal diseases (PD) are inflammatory conditions that affect the teeth supporting tissues. Increased body fat tissues may contribute to activation of the systemic inflammatory response, leading to comorbidities. Some studies have shown that individuals with obesity present higher incidence of PD than eutrophics.To investigate the impact of obesity on periodontal tissues and oral microbiota in mice.Two obesity mice models were performed, one using 12 weeks of the dietary protocol with a high-fat (HF) diet in C57BL/6 mice and the other using leptin receptor-deficient mice (db/db-/-), which became spontaneously obese. After euthanasia, a DNA-DNA hybridization technique was employed to evaluate the microbiota composition and topical application of chlorhexidine (CHX), an antiseptic, was used to investigate the impact of the oral microbiota on the alveolar bone regarding obesity.Increased adipose tissue may induce alveolar bone loss, neutrophil recruitment, and changes in the oral biofilm, similar to that observed in an experimental model of PD. Topical application of CHX impaired bone changes.Obesity may induce changes in the oral microbiota and neutrophil recruitment, which are associated with alveolar bone loss.

Oral microbiology

10.1590/1678-7757-2022-0238

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Flight reactions induced by injection of glutamate N-methyl-d-aspartate receptor agonist into the rat dorsolateral periaqueductal gray are not dependent on endogenous nitric oxide

Pharmacology Biochemistry and Behavior (2006)

Daniele C. Aguiar Fabrício A. Moreira Francisco Silveira Guimarães

Periaqueductal gray

10.1016/j.pbb.2006.02.010

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NOC-9, a selective nitric oxide donor, induces flight reactions in the dorsolateral periaqueductal gray of rats by activating soluble guanylate cyclase

Neuroscience Letters (2009)

Andréa Arantes Braga Daniele C. Aguiar Francisco Silveira Guimarães

Previous studies have showed that SIN-1, a nitric oxide (NO) donor, injected into the dorsolateral column of the periaqueductal gray (dlPAG) induces flight reactions. This drug, however, can also produce peroxynitrite, which may interfere in this effect. In addition, it is also unknown if this effect is mediated by local activation of soluble guanylate cyclase (sGC). The aims of this study, therefore, were (1) to investigate if NOC-9 (6-(2-Hydroxy-1-methyl-2-nitrosohydrazino)-N-methyl-1-hexanamine), a NO donor that does not produce peroxynitrite, would produce flight reactions after intra-dlPAG administration similar to those induced by SIN-1; (2) to verify if these responses could be prevented by local injection of a selective guanylate cyclase inhibitor (ODQ). Male Wistar rats (n=5-12) with cannulae aimed at the dlPAG received injections of TRIS (pH 10.0, 0.5 microl), NOC-9 (75 and 150 nmol), saline or SIN-1 (200 nmol) and were placed in an open arena for 10 min. In a subsequent experiment animals (n=7-8) were pretreated with ODQ (1 nmol/0.5 microl) before receiving NOC-9 150 nmol. NOC-9 induced a significant dose-dependent increase in flight reactions in the first minute after injection (% of animals displaying flight: vehicle=0%, NOC 75=67%, NOC 150=75%). SIN-1 had a similar effect (100% of animals showing flight) but the effects lasted longer (10 min) than those of NOC-9. The effect of NOC-9 (150 nmol) was prevented by pretreatment with ODQ (% of animals displaying flight: vehicle+NOC 150=71%, ODQ+NOC 150=37%). The results suggest that NO donors injected into the dlPAG induce defensive responses that are not mediated by secondary peroxynitrite production. Moreover, they also indicate that these defensive responses depend on activation of local sGC. The data strengthen the proposal that NO can modulate defensive reactions in the dlPAG.

Periaqueductal gray

Soluble guanylyl cyclase

10.1016/j.neulet.2009.05.009

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Citations (28)

Modulation of anxiety-like behaviour by Transient Receptor Potential Vanilloid Type 1 (TRPV1) channels located in the dorsolateral periaqueductal gray

European Neuropsychopharmacology (2008)

Ana Luisa B. Terzian Daniele C. Aguiar Francisco Silveira Guimarães Fabrício A. Moreira

Capsazepine

Periaqueductal gray

AM251

Anandamide

Capsaicin

10.1016/j.euroneuro.2008.11.004

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Citations (107)

Papel da neurotransmissão noradrenérgica da substância cinzenta periaquedutal dorsal na modulação de comportamentos defensivos relacionados aos transtornos de ansiedade generalizada e de pânico

Valquíria Camin de Bortoli Ana Paula Santana de Vasconcellos Bittencourt Daniele C. Aguiar

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Neuroimmune circuits involved in β-lactoglobulin-induced food allergy

bioRxiv (Cold Spring Harbor Laboratory) (2020)

Luísa Lemos Helder Carvalho de Assis Juliana de Jesus Monteiro Alves Daniela Silva Reis Maria Cecília Campos Canesso

ABSTRACT Cow’s milk allergy is the most prevalent food allergy that usually begins early in life and β- lactoglobulin (BLG) is the milk component with the highest allergenicity. It has been described that ovalbumin (OVA)-induced food allergy in mice is associated with anxiety and aversive behavior. However, it is yet to be determined whether altered behavior is a general component of food allergy or whether it is specific for some types of allergens. Thus, we investigated behavioral and neuroimmune circuits triggered by allergic sensitization to BLG. We found a neuroimmune conflict between aversion and reward in a model of food allergy induced to BLG. Mice sensitized to BLG did not present aversive behavior when the allergen was used for sensitization and oral challenge. Mice allergic to BLG preferred to drink the allergen-containing solution over water even though they presented high levels of specific IgE, inflammatory cells in the intestinal mucosa and significant weight loss. When sensitized to OVA and orally challenged with the same antigen, mice had display neuron activation in the amygdala suggesting an anxiety-related sensation. On the other hand, OVA-sensitized mice showed preference to consume a mixture of BLG and OVA during oral challenge in spite of their aversion to OVA. Consumption of OVA-BLG solution was associated with neuron activation in the nucleus accumbens, suggesting a reward sensation. Thus, the aversive behavior observed in food allergy to OVA does not apply to all antigens and some allergens may induce preference rather than aversion. Our study provides new insights into the neuroimmune conflicts regarding preference and avoidance to a common antigen associated with food allergy.

Milk allergy

10.1101/2020.08.17.248310

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Animal models of anxiety disorders and stress

Brazilian Journal of Psychiatry (2013)

Alline C. Campos Manoela V. Fogaça Daniele C. Aguiar Francisco Silveira Guimarães

Anxiety and stress-related disorders are severe psychiatric conditions that affect performance in daily tasks and represent a high cost to public health. The initial observation of Charles Darwin that animals and human beings share similar characteristics in the expression of emotion raise the possibility of studying the mechanisms of psychiatric disorders in other mammals (mainly rodents). The development of animal models of anxiety and stress has helped to identify the pharmacological mechanisms and potential clinical effects of several drugs. Animal models of anxiety are based on conflict situations that can generate opposite motivational states induced by approach-avoidance situations. The present review revisited the main rodent models of anxiety and stress responses used worldwide. Here we defined as "ethological" the tests that assess unlearned/unpunished responses (such as the elevated plus maze, light-dark box, and open field), whereas models that involve learned/punished responses are referred to as "conditioned operant conflict tests" (such as the Vogel conflict test). We also discussed models that involve mainly classical conditioning tests (fear conditioning). Finally, we addressed the main protocols used to induce stress responses in rodents, including psychosocial (social defeat and neonatal isolation stress), physical (restraint stress), and chronic unpredictable stress.

Animal model

Affect

10.1590/1516-4446-2013-1139

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Citations (420)

Blockade of NMDA or NO in the dorsal premammillary nucleus attenuates defensive behaviors

Physiology & Behavior (2011)

Daniele C. Aguiar Francisco Silveira Guimarães

The dorsal premammillary nucleus (PMd) is a hypothalamic structure that plays a pivotal role in the processing of predatory threats. Lesions of this nucleus virtually eliminate the expression of defensive responses to predator exposure. However, little is known about the neurotransmitters responsible for these behavioral responses. Since PMd neurons express ionotropic glutamate receptors and exposure to predators have been shown to activate nitric oxide (NO) producing cells in this region, the aim of this study was to verify the involvement of glutamate and NO-mediated neurotransmission in defensive reactions modulated by the PMd. We tested in male Wistar rats the hypothesis that intra-PMd injection of the NMDA receptor antagonist, AP7, or the NO synthase inhibitor, N-propyl-L-arginine (NP), would attenuate behavioral responses induced by cat exposure. Our results showed that both AP7 and NP significantly attenuated the behavioral responses induced by the live cat. These results suggest that the NMDA/NO pathway plays an important role in the behavioral responses mediated by the PMd.

10.1016/j.physbeh.2011.02.034

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Citations (15)