Yi‐Cheng Lin

National Taiwan Normal University

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Chin‐Lan Huang

National Taiwan University of Science and Technology

Hung-yi Lee

National Taiwan University

Chun‐Yao Huang

Taipei Medical University Hospital

Li‐Nien Chien

National Yang Ming Chiao Tung University

Szu‐Ying Lin

National Taiwan University

Tzu-Quan Lin

National Taiwan University

Pei‐Ning Wang

National Yang Ming Chiao Tung University

Yi‐Jung Lee

National Yang Ming Chiao Tung University

Yuarn‐Jang Lee

Taipei Medical University-Shuang Ho Hospital

Bi‐Li Chen

Taipei Medical University Hospital

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National Taiwan University

Taipei Medical University

Taipei Medical University Hospital

National Yang Ming Chiao Tung University

Taipei Veterans General Hospital

National Tsing Hua University

Taipei Medical University-Shuang Ho Hospital

National Cheng Kung University

National Taipei University

National Taiwan University Hospital

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EME33: A Dataset of Classical Piano Performances Guided by Expressive Markings with Application in Music Rendering

2021 IEEE International Conference on Big Data (Big Data) (2024)

Truong Nguyen Khanh Hung Jingjing Tang Keith Armstrong Yi‐Cheng Lin Yiwen Liu

10.1109/bigdata62323.2024.10826039

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Platelet-Rich Fibrin–Augmented Gap-Bridging Strategy in Rabbit Anterior Cruciate Ligament Repair

The American Journal of Sports Medicine (2023)

Pei-Wei Weng Chih‐Hwa Chen Yi‐Cheng Lin Kuan‐Hao Chen Yi-Yen Yeh

We assessed the efficacy of a novel platelet-rich fibrin (PRF)-augmented repair strategy for promoting biological healing of an anterior cruciate ligament (ACL) midsubstance tear in a rabbit model. The biological gap-bridging effect of a PRF scaffold alone or in combination with rabbit ligamentocytes on primary ACL healing was evaluated both in vitro and in vivo.A PRF matrix can be implanted as a provisional fibrin-platelet bridging scaffold at an ACL defect to facilitate functional healing.Controlled laboratory study.The biological effects of PRF on primary rabbit ligamentocyte proliferation, tenogenic differentiation, migration, and tendon-specific matrix production were investigated for treatment of cells with PRF-conditioned medium (PRFM). Three-dimensional (3D) lyophilized PRF (LPRF)-cell composite was fabricated by culturing ligamentocytes on an LPRF patch for 14 days. Cell-scaffold interactions were investigated under a scanning electron microscope and through histological analysis. An ACL midsubstance tear model was established in 3 rabbit groups: a ruptured ACL was treated with isolated suture repair in group A, whereas the primary repair was augmented with LPRF and LPRF-cell composite to bridge the gap between ruptured ends of ligaments in groups B and C, respectively. Outcomes-gross appearance, magnetic resonance imaging, and histological analysis-were evaluated in postoperative weeks 8 and 12.PRFM promoted cultured ligamentocyte proliferation, migration, and expression of tenogenic genes (type I and III collagen and tenascin). PRF was noted to upregulate cell tenogenic differentiation in terms of matrix production. In the 3D culture, viable cells formed layers at high density on the LPRF scaffold surface, with notable cell ingrowth and abundant collagenous matrix depositions. Moreover, ACL repair tissue and less articular cartilage damage were observed in knee joints in groups B and C, implying the existence of a chondroprotective phenomenon associated with PRF-augmented treatment.Our PRF-augmented strategy can facilitate the formation of stable repair tissue and thus provide gap-bridging in ACL repair.From the translational viewpoint, effective primary repair of the ACL may enable considerable advancement in therapeutic strategy for ACL injuries, particularly allowing for proprioception retention and thus improved physiological joint kinematics.

Platelet-rich fibrin

10.1177/03635465221149993

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Association of multiple preventive therapies postdischarge and long-term health outcomes after acute myocardial infarction

Journal of the Chinese Medical Association (2021)

Chih‐Wei Chen Yi‐Cheng Lin Chun-Ming Shih Wan‐Ting Chen Feng‐Yen Lin

Statins, beta-blockers, and angiotensin-converting enzyme inhibitors/angiotensin II receptor blockers have been advocated by guidelines as secondary prevention medications to improve the long-term outcomes of post-acute myocardial infarction (AMI) patients. However, adequate drug adherence has always been challenging, and different treatment regimens may lead to divergent outcomes that remain unclear under current myocardial infarction (MI) care standards. This study investigated the association between use of different preventive regimens post-AMI and patients' long-term outcomes.This cohort study used data files from the Taiwan National Health Insurance Research Database. A total of 77 520 people who were hospitalized with AMI between 2002 and 2015 were assessed. On the basis of medication possession ratio (MPR) to individual medications, eight treatment groups were examined in this study. Receiving therapy was defined as MPR ≥40%. We investigated the association between different treatment groups and all-cause mortality in 24 months.Overall, 51 322 patients with ST-elevation MI and 26 198 with non-ST-elevation MI were included in the study. Patients received all three preventive medications show the lowest mortality in 24 months follow-up periods among all treatment groups. Patients who did not usage of any of these three preventive medications had the highest mortality in 24 months (adjusted hazard ratio, 1.78; 95% CI, 1.64-1.93). This mortality rate had the same pattern across the three cohort generations (2002-2005, 2006-2010, and 2011-2015).In this large population-based real-world study, usage of three preventive therapies post-MI was associated with the lowest rate of all-cause mortality.

10.1097/jcma.0000000000000621

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Subacute Bioprosthetic Mitral Valve and Inter-Atrial Septum Mural Thrombosis.

PubMed (2024)

Pingping Wang Chuan-Chih Hsu Chih-Wei Chen Yi‐Cheng Lin Chun‐Yao Huang

Atrial septum

Mural

10.6515/acs.202409_40(5).20240617c

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Clinical course of early and late mild cognitive impairment

Alzheimer s & Dementia (2020)

Szu‐Ying Lin Po‐Chen Lin Yi‐Cheng Lin Yi‐Jung Lee Pei‐Ning Wang

Abstract Background Amnestic mild cognitive impairment can be sorted to early mild cognitive impairment (EMCI) or late mild cognitive impairment (LMCI) according to severity of memory impairment. The aim of present study is to compare the prognosis and clinical course between EMCI and LMCI. Method From January 2009 to December, 2017, we recruited 640 participants from memory and dementia clinic at the Neurology Department of Taipei Veteran General Hospital. All patients receive at least two series neuropsychological evaluation annually and were categorized to EMCI or LMCI according to ADNI‐2 criteria. Result Total 186 patients with EMCI and 277 patients with LMCI were included. 177 cognitive normal participants were also included as normal control. The mean follow‐up duration was 2.85 ± 2.02 years (minimal: 1, maximum: 9 years). At the secondary year, 58 (31.2%) EMCI and 9 (3.2%) LMCI reversed to normal cognitive status. Annual dementia conversion rates were 1.61, 4.41, 21.98 per person year in NC, EMCI and LMCI groups, respectively. EMCI and LMCI had higher rate of progression to dementia (Log rank test, p<0.001) than normal subjects. Both MCI groups showed significant decline in global function (MMSE) and executive function (digital forward, Trail making test A (time), Trail making test B (line) and verbal fluency) than those in normal subjects. No significant different was found in episodic memory and language function between converters and non‐converters Conclusion Both early and late MCI showed higher risk of dementia. Although MCI showed wide variation in neuropsychological tasks and clinical diagnosis during follow‐up periods, there was higher global and executive functional decline.

Verbal fluency test

10.1002/alz.039825

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BreezyVoice: Adapting TTS for Taiwanese Mandarin with Enhanced Polyphone Disambiguation -- Challenges and Insights

arXiv (Cornell University) (2025)

Chan-Jan Hsu Yi‐Cheng Lin Chia-Chun Lin Wei-Chih Chen Hsiao‐Min Chung

We present BreezyVoice, a Text-to-Speech (TTS) system specifically adapted for Taiwanese Mandarin, highlighting phonetic control abilities to address the unique challenges of polyphone disambiguation in the language. Building upon CosyVoice, we incorporate a $S^{3}$ tokenizer, a large language model (LLM), an optimal-transport conditional flow matching model (OT-CFM), and a grapheme to phoneme prediction model, to generate realistic speech that closely mimics human utterances. Our evaluation demonstrates BreezyVoice's superior performance in both general and code-switching contexts, highlighting its robustness and effectiveness in generating high-fidelity speech. Additionally, we address the challenges of generalizability in modeling long-tail speakers and polyphone disambiguation. Our approach significantly enhances performance and offers valuable insights into the workings of neural codec TTS systems.

Mandarin Chinese

10.48550/arxiv.2501.17790

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Abstract 15477: Association With Post Discharge Adherence to Guideline Directed Medical Therapy and Long Term Health Outcome

Circulation (2020)

Chih‐Wei Chen Chun‐Yao Huang Li‐Nien Chien Yi‐Cheng Lin

Introduction: Statin, beta-blocker and Angiotensin-converting enzyme inhibitors/angiotensin II receptor blockers have been advocated by guideline as secondary prevention medications to improve long term outcome post myocardial infarction for years. However, in reality, adherence to these medications have always been challenging and different treatment regimen adherence might lead to divergent outcomes which remains unclear in current AMI standard care. Hypothesis: To investigate the association between different guideline-directed medication regimen adherence post myocardial infarction and long-term outcomes. Methods: This cohort study used data files from Taiwan National Health Insurance Research Database (NHIRD). A total of 77520 survivors of hospitalization with AMI between 2002 and 2015 were assessed. Base on adherence to individual medications, eight treatment groups were estimated in this study. We investigate the association of adherence to different treatment groups and all-cause mortality in 24 months. Results: 51322 STEMI patients and 26198 NSTEMI patients were included in the study. All treatment groups had significant higher mortality compare with patients who adhered to all 3 medications in 24 months follow-up. Patients not adherence to any medications had the highest mortality in 24 months (adjusted HR: 1.78; 95% CI: 1.64 to 1.93). Conclusions: In this large population base real-world data study, we found that adherence to all 3 secondary prevention medications in post myocardial infarction survivor was associated lower rate of all cause mortality.

Guideline

Regimen

Angiotensin Receptor Blockers

10.1161/circ.142.suppl_3.15477

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Reduction of hospital levofloxacin use is associated with a decrease in hospital-acquired fluoroquinolone-resistant Pseudomonas aeruginosa rates: An 11 year study

Journal of Microbiology Immunology and Infection (2015)

Li-Hsing Tsao Hsin-Yi Liu Yi‐Cheng Lin Liyuan Chen Yuarn‐Jang Lee

10.1016/j.jmii.2015.02.448

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Building a Taiwanese Mandarin Spoken Language Model: A First Attempt

arXiv (Cornell University) (2024)

Chih-Kai Yang Yu-Kuan Fu Chen-An Li Yi‐Cheng Lin Yuxiang Lin

This technical report presents our initial attempt to build a spoken large language model (LLM) for Taiwanese Mandarin, specifically tailored to enable real-time, speech-to-speech interaction in multi-turn conversations. Our end-to-end model incorporates a decoder-only transformer architecture and aims to achieve seamless interaction while preserving the conversational flow, including full-duplex capabilities allowing simultaneous speaking and listening. The paper also details the training process, including data preparation with synthesized dialogues and adjustments for real-time interaction. We also developed a platform to evaluate conversational fluency and response coherence in multi-turn dialogues. We hope the release of the report can contribute to the future development of spoken LLMs in Taiwanese Mandarin.

Mandarin Chinese

Spoken Language

10.48550/arxiv.2411.07111

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The Flexibility of Physio-Cognitive Decline Syndrome: A Longitudinal Cohort Study

Frontiers in Public Health (2022)

Yi‐Cheng Lin Chih‐Ping Chung Pei‐Lin Lee Kun‐Hsien Chou L. Chang

The mutual presence of impairments in physical and cognitive functions in older adults has been reported to predict incident disability, dementia, and mortality. The longitudinal transitions of phenotypes between these functional impairments, either individually or in combination, remain unclear. To investigate the natural course and prevalence of physical and/or cognitive impairments (CIs), we enrolled participants from a community-based population. Data were retrieved from the first (August 2011 and December 2012) and second wave (August 2013 and June 2015) of the I-Lan Longitudinal Aging Study (ILAS). All participants were classified into four groups: robust, mobility impairment (MI), CI, and physio-cognitive decline syndrome (PCDS). MI was diagnosed with weakness and/or slowness. CI was diagnosed if a subject met a cutoff below 1.5 standard deviations (SDs) of age-, sex-, and education-matched norms of any neuropsychological assessments. PCDS was combined with MI and CI. Our results showed that 38, 14, 30, and 18% of the participants were on the robust, MI, CI, and PCDS at the first wave, respectively. After 2.5 years, 17% robust, 29% MI, and 37% CI progressed to PCDS. In contrast, 33% of PCDS was reversed to non-PCDS. Predictors of conversion to PCDS included worse memory and language functions, older age, lower muscle mass, and the presence of diabetes. In PCDS, a stronger hand-grip strength, younger age, and better memory functions predicted reversion to non-PCDS status. In summary, we probed the transition of PCDS. The skeletal muscle mass/function and memory function are crucial factors associated with PCDS reversion or progression.

Longitudinal Study

Clinical Dementia Rating

Cognitive Decline

10.3389/fpubh.2022.820383

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Citations (6)