Amanda Cosmo de Almeida

Universidade Estadual Paulista (Unesp)

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Co-Authors

Patrícia Osório Ferreira

Universidade Estadual Paulista (Unesp)

Flávio Júnior Caires

Universidade Estadual Paulista (Unesp)

ÉC

Éverton Carvalho dos Santos

Norwegian University of Science and Technology

Carolina Torquetti

Universidade Estadual Paulista (Unesp)

Ana Carolina Kogawa

Universidade Federal de Goiás

Richard Perosa Fernandes

Universidade Estadual Paulista (Unesp)

R. Droppa

Universidade Federal do ABC

Aniele de Moura

Universidade de São Paulo

Fábio Furlan Ferreira

Universidade Federal do ABC

Ricardo A. E. Castro

University of Coimbra

Cooperative Institutions

Universidade Estadual Paulista (Unesp)

University of Coimbra

Centro Universitário de Araraquara

Universidade Federal da Paraíba

Universidade de São Paulo

Universidade Federal de Mato Grosso

McGill University

Jewish General Hospital

Hospital Universitário Lauro Wanderley

Universidade Federal do Rio Grande do Norte

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Thermal study and characterization of new cocrystals of ciprofloxacin with picolinic acid

Journal of Thermal Analysis and Calorimetry (2021)

Carolina Torquetti Patrícia Osório Ferreira Amanda Cosmo de Almeida Richard Perosa Fernandes Flávio Júnior Caires

Cocrystal

Thermogravimetry

Powder Diffraction

Differential thermal analysis

10.1007/s10973-020-10479-3

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Citations (8)

Mechanochemical synthesis, thermoanalytical study and characterization of new multicomponent solid forms of norfloxacin with saccharin

Journal of Thermal Analysis and Calorimetry (2021)

Patrícia Osório Ferreira Aniele de Moura Amanda Cosmo de Almeida Éverton Carvalho dos Santos Ana Carolina Kogawa

Cocrystal

Saccharin

10.1007/s10973-021-10658-w

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Citations (14)

Alguns cocristais de ciprofloxacino: síntese mecanoquímica, caracterização e ensaio de solubilidade

Amanda Cosmo de Almeida

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Cocrystals of ciprofloxacin with nicotinic and isonicotinic acids: Mechanochemical synthesis, characterization, thermal and solubility study

Thermochimica Acta (2019)

Amanda Cosmo de Almeida Carolina Torquetti Patrícia Osório Ferreira Richard Perosa Fernandes Éverton Carvalho dos Santos

Thermogravimetry

Stoichiometry

Cocrystal

Isonicotinic acid

Powder Diffraction

Differential thermal analysis

10.1016/j.tca.2019.178346

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Citations (35)

Mechanochemical synthesis, characterization and thermal study of new cocrystals of ciprofloxacin with pyrazinoic acid and p-aminobenzoic acid

Journal of Thermal Analysis and Calorimetry (2019)

Amanda Cosmo de Almeida Patrícia Osório Ferreira Carolina Torquetti Bruno Ekawa Ana Carina Sobral Carvalho

Thermogravimetry

Differential thermal analysis

Cocrystal

Stoichiometry

Thermal Stability

10.1007/s10973-019-08958-3

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Citations (12)

Novel nimesulide multicomponent solid forms: screening, synthesis, thermoanalytical study and characterization

Journal of Thermal Analysis and Calorimetry (2024)

Amanda Cosmo de Almeida Patrícia Osório Ferreira Maria Vitória Porto João Canotilho Ricardo A. E. Castro

Abstract Nimesulide (NMS) is a widely used non-steroidal anti-inflammatory drug, however, presents low aqueous solubility. One way to overcome the solubility issue of drugs is altering their solid forms through some approaches like cocrystals, coamorphous, and eutectic mixtures. The purpose of this work was to prospect new multicomponent solid forms of NMS. A virtual-experimental cocrystal screening was carried out through COSMOquick software and mechanochemical experiments. Alternatively, dual-drug coamorphous systems were investigated by quench cooling and/or cryomilling processes. All solid samples were characterized using differential scanning calorimetry (DSC), powder X-ray diffraction (PXRD) and infrared spectroscopy (FTIR). The results confirmed the successful synthesis of a NMS-piperazine cocrystal (NMS-PPZ), two new eutectic mixtures NMS-gentisic acid (NMS-GSA) and NMS-isoniazid (NMS-INH), as well as novel drug-drug coamorphous systems. The eutectic compositions were determined by binary solid–liquid phase diagram construction and Tamman’s triangle plot. Nimesulide-omeprazole (NMS-OMP) coamorphous system was found to be stable for at least 120 days in dry conditions. The coamorphous system with bicalutamide (NMS-BICA) prepared by quench cooling process is more stable than that obtained by cryomilling. Finally, the dissolution rate study demonstrated that NMS multicomponent systems are dissolved relatively faster than pure drug.

Characterization

Nimesulide

Thermogravimetry

10.1007/s10973-024-13189-2

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Citations (2)

Cobalt selenate pentahydrate: Thermal decomposition intermediates and their properties dependence on temperature changes

Thermochimica Acta (2020)

Rafael de Godoi Machado Caroline Gaglieri Rafael Turra Alarcon Aniele de Moura Amanda Cosmo de Almeida

Selenate

Thermogravimetry

Differential thermal analysis

Powder Diffraction

10.1016/j.tca.2020.178615

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Citations (5)

Norfloxacin Cocrystals: Mechanochemical Synthesis and Scale-up Viability Through Solubility Studies

Journal of Pharmaceutical Sciences (2023)

Patrícia Osório Ferreira Amanda Cosmo de Almeida Giovanna de Paula Costa Carolina Torquetti João A. Baptista

Cocrystals are recognized as one of the most efficient approaches to improve aqueous solubility of Biopharmaceutical Classification System, BCS, classes II and IV drugs. Cocrystal discovery and the establishment of experimental conditions suitable for scale-up purposes are some of the main challenges in cocrystal investigation. In this work, the investigation of mechanochemical synthesis of norfloxacin cocrystals with picolinic and isonicotinic acids is performed, leading to the discovery of two new cocrystals of this important BCS class IV antibiotic, which were characterized through thermal, spectral and diffractometric analysis. Norfloxacin apparent aqueous solubility using the cocrystals is also presented, with higher values being obtained for all the investigated systems when compared to the pure drug. Norfloxacin has 3 polymorphs and several solvents/hydrates, which represents a challenge for obtaining pure cocrystal forms from solvent crystallization. This challenge was successfully overcome in this work, as experimental conditions to obtain the pure cocrystals (the new ones and also norfloxacin-nicotinic acid and norfloxacin-saccharin) were established using Crystal16 equipment. This is a crucial step to envisage future scale-up procedures and therefore a valuable information for the pharmaceutical industry.

Cocrystal

Biopharmaceutical

10.1016/j.xphs.2023.03.003

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Citations (6)

Effect of hydroxyapatite and 45S5 bioactive glass addition on a dental adhesive resin cement

International Journal of Applied Glass Science (2020)

Julia Magalhães da Costa Lima Assad Roberta Ferreti Bonan Lilian Costa Anami Amanda Cosmo de Almeida Ísis de Araújo Ferreira Muniz

Abstract Objective This study evaluates the mechanical, physical, and biological properties of resin‐based dental cement (RelyX ARC, 3M ESPE) incorporated with hydroxyapatite and 45S5 bioactive glass. Methods Bioactive glass (45S5) and hydroxyapatite (HA) were added to cement in different proportions (10 wt% and 20 wt%). Three‐point flexural strength, microhardness, surface roughness, film thickness, contact angle, and color were evaluated. Cytotoxicity in human osteoblasts culture (MG63) was evaluated. Statistical analysis was performed using one‐way and two‐way ANOVA and Tukey tests (α < 0.05). Results The addition of HA and 45S5 bioactive glass reduced the flexural strength of the composite. However, the resistance value was greater than the minimum values of the ISO standard. Film thickness was below the maximum values, except for the 20% HA. The contact angle was constant at 24 hours and 14 days, except for 10% 45S5 group, which presented a significant decrease in mean contact angle. Cellular viability for all groups increased from the first to the 14th day. Additionally, the cellular viability was above 50%. Conclusions In vitro incorporation of 45S5 bioactive glass on resin cement resulted in a promising luting dental material with adequate mechanical properties, thin film thickness, improved wettability, and adequate biocompatibility.

Bioactive Glass

Biocompatibility

Dental cement

10.1111/ijag.15850

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Citations (4)

CCDC 1999991: Experimental Crystal Structure Determination

The Cambridge Structural Database (2020)

Patrícia Osório Ferreira Amanda Cosmo de Almeida Éverton Carvalho dos Santos R. Droppa Fábio Furlan Ferreira

10.5517/ccdc.csd.cc2544vb

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Citations (0)