Amit Jaiswal

Indian Institute of Technology Mandi

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Co-Authors

Vikrant Sudan

Uttar Pradesh Pandit Deen Dayal Upadhyaya Pashu Chikitsa Vigyan Vishwavidyalaya Evam Go-Anusandhan Sansthan

Daya Shanker

Uttar Pradesh Pandit Deen Dayal Upadhyaya Pashu Chikitsa Vigyan Vishwavidyalaya Evam Go-Anusandhan Sansthan

Shounak Roy

Indian Institute of Technology Mandi

Prem Singh

Oregon State University

Rahul Parashar

Guru Angad Dev Veterinary and Animal Sciences University

Arun Chattopadhyay

Indian Institute of Technology Guwahati

Siddhartha Sankar Ghosh

Indian Institute of Technology Guwahati

Keshav Bhardwaj

Indian Institute of Technology Mandi

Dinesh S. Rao

University of California, Los Angeles

Tiffany M. Tran

University of California, Los Angeles

Cooperative Institutions

Banaras Hindu University

Uttar Pradesh Pandit Deen Dayal Upadhyaya Pashu Chikitsa Vigyan Vishwavidyalaya Evam Go-Anusandhan Sansthan

Indian Institute of Technology Mandi

Lovely Professional University

All India Institute of Medical Sciences

Nanaji Deshmukh Veterinary Science University

University of California, Los Angeles

Indian Institute of Technology BHU

Indian Veterinary Research Institute

Institute of Medical Sciences

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Poly(allylamine hydrochloride)-functionalized Reduced Graphene Oxide for Synergistic chemo-photothermal Therapy

Nanomedicine (2019)

Shounak Roy Ankita Sarkar Amit Jaiswal

Aim: To develop near-infrared (NIR) light-responsive reduced graphene oxide (RGO)-based nanocomposites with improved stability, biocompatibility and enhanced in vitro chemo-photothermal therapeutic efficiency. Materials & methods: Poly(allylamine hydrochloride)-functionalized RGO-based nanocomposites (RGO-PAH) were synthesized and thoroughly characterized. In vitro biocompatibility, cellular uptake and in vitro synergistic chemo-photothermal therapeutic efficiency of drug-loaded RGO-PAH nanocomposites were evaluated along with elucidation of cell death mechanism. Results: RGO-PAH nanocomposites showed excellent photothermal transduction, pH-dependent drug release, rapid internalization, high biocompatibility and highly efficient synergistic in vitro chemo-photothermal therapy via apoptosis induction through increase in intracellular reactive oxygen species (ROS) production followed by oxidative DNA damage. Conclusion: Excellent biocompatibility and highly efficient chemo-photothermal killing of cancer cells at a very low concentration reflects the potential of RGO-PAH as a NIR-responsive therapeutic agent for cancer therapy.

Biocompatibility

Allylamine

Surface Modification

10.2217/nnm-2018-0320

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Citations (31)

Small molecule inhibition of RNA binding proteins in haematologic cancer

RNA Biology (2024)

Amit Jaiswal Michelle L. Thaxton Georgia Scherer Jacob P. Sorrentino Neil K. Garg

In recent years, advances in biomedicine have revealed an important role for post-transcriptional mechanisms of gene expression regulation in pathologic conditions. In cancer in general and leukaemia specifically, RNA binding proteins have emerged as important regulator of RNA homoeostasis that are often dysregulated in the disease state. Having established the importance of these pathogenetic mechanisms, there have been a number of efforts to target RNA binding proteins using oligonucleotide-based strategies, as well as with small organic molecules. The field is at an exciting inflection point with the convergence of biomedical knowledge, small molecule screening strategies and improved chemical methods for synthesis and construction of sophisticated small molecules. Here, we review the mechanisms of post-transcriptional gene regulation, specifically in leukaemia, current small-molecule based efforts to target RNA binding proteins, and future prospects.

Biomedicine

Post-transcriptional regulation

10.1080/15476286.2024.2303558

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Citations (3)

Advancements in Polymer Modification: A Comprehensive Review on Techniques

International Journal of Pharmaceutical Sciences and Medicine (2025)

Rasika Nikhade Amit Jaiswal

Polymers are crucial in modern material science, with continuous advancements in their modification techniques offering vast possibilities across various applications. In the last decade, methods such as physical blending, nanofiller integration, and surface treatments have greatly enhanced the mechanical and thermal properties of polymers. These techniques allow for the tailoring of polymers to meet specific performance needs, thereby broadening their use in industries ranging from automotive to electronics. Chemical modification methods like crosslinking, functionalization, and coupling reactions have enabled the creation of highly adaptable materials with improved durability and performance. These processes are particularly beneficial in applications requiring polymers with precise mechanical, chemical, and thermal characteristics. Techniques such as grafting and controlled polymerization have also contributed to the development of responsive and self-healing polymers, which have paved the way for smart materials. These polymers can adapt to environmental changes, self-repair damage, and offer longer service lives. At the same time, biological and enzymatic modifications have led to the development of biocompatible and eco-friendly materials, making significant progress towards sustainability in polymer applications, especially in the fields of biomedicine and environmental solutions. The combination of nanotechnology and additive manufacturing has introduced hybrid modification techniques, blending traditional methods with innovative approaches. These hybrid methods enhance polymer functionality and open new possibilities for applications in areas like electronics, energy storage, and medical devices. However, challenges remain, particularly in scaling these techniques for large-scale production and ensuring the sustainability of polymer materials. This review examines the mechanisms, benefits, and limitations of these methods, evaluating their potential to meet future technological demands. It serves as a valuable resource for advancing polymer science and developing next-generation materials that can cater to the evolving needs of industry, environment, and technology.

Surface Modification

10.47760/ijpsm.2025.v10i01.005

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CCDC 2209500: Experimental Crystal Structure Determination

The Cambridge Structural Database (2023)

Akhilesh Kumar Praveen Singh Ranjeet Kumar Priyanka Yadav Amit Jaiswal

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.

10.5517/ccdc.csd.cc2d556z

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Variation in clinical markers in cattle naturally infected with bovine tropical theileriosis

Journal of Parasitic Diseases (2015)

Rahul Parashar Vikrant Sudan Amit Jaiswal Daya Shanker

Emaciation

Hypersalivation

Abdominal distension

Anorexia

Melena

10.1007/s12639-015-0721-x

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Citations (1)

Organic Nanomaterials

CRC Press eBooks (2024)

Tanu Gupta Amit Jaiswal Ranjeet Ranjan Kumar Ranjeet Ranjan Kumar

There has been significant research in the area of nanotechnology using organic nanomaterials. In the field of modern material science, organic nanoparticles are emerging as a novel drug delivery system; they have a wide-ranging industrial, biomedical, and electronic applications and magnetic, environmental, and catalytic properties. These new-generation organic nanomaterials have controlled morphology, high stability, large surface area, tunable compositions, abundant physicochemical multifunctionality, and well-defined properties, which enable a broad range of useful applications. The chemical composition and shape of a nanoparticle influence specific properties. The main groups of organic nanomaterials are liposomes, polymeric micelles, protein/peptide-based nanomaterials, carbon nanomaterials (e.g. fullerenes, carbon nanotubes, and graphene), and dendrimers.

Nanomaterials

10.1201/9781003481157-11

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Citations (2)

Effect of Petrographic Properties on the Strength Parameters of Indian Metamorphic Rocks

Lecture notes in civil engineering (2022)

A. K. Verma Amit Jaiswal T. N. Singh

Parent rock

10.1007/978-981-16-9770-8_50

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Citations (1)

First report of molecular characterization and sequence phylogenetic analysis of Linguatula serrata from India

Acta Parasitologica (2018)

Vikrant Sudan Daya Shanker Amit Jaiswal

10.1515/ap-2018-0093

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Citations (4)

Reusable MoS₂-Modified Antibacterial Fabrics with Photothermal Disinfection Properties for Repurposing of Personal Protective Masks

ACS Applied Materials & Interfaces (2021)

Praveen Kumar Shounak Roy Ankita Sarkar Amit Jaiswal

The current pandemic caused by SARS-CoV-2 has seen a widespread use of personal protective equipment, especially face masks. This has created the need to develop better and reusable protective masks with built-in antimicrobial, self-cleaning, and aerosol filtration properties to prevent the transmission of air-borne pathogens such as the coronaviruses. Herein, molybdenum disulfide (MoS2) nanosheets are used to prepare modified polycotton fabrics having excellent antibacterial activity and photothermal properties. Upon sunlight irradiation, the nanosheet-modified fabrics rapidly increased the surface temperature to ∼77 °C, making them ideal for sunlight-mediated self-disinfection. Complete self-disinfection of the nanosheet-modified fabric was achieved within 3 min of irradiation, making the fabrics favorably reusable upon self-disinfection. The nanosheet-modified fabrics maintained the antibacterial efficiency even after 60 washing cycles. Furthermore, the particle filtration efficiency of three-layered surgical masks was found to be significantly improved through incorporation of the MoS2-modified fabric as an additional layer of protective clothing, without compromising the breathability of the masks. The repurposed surgical masks could filter out around 97% of 200 nm particles and 96% of 100 nm particles, thus making them potentially useful for preventing the spread of coronaviruses (120 nm) by trapping them along with antibacterial protection against other airborne pathogens.

Nanosheet

Molybdenum disulfide

Filtration (mathematics)

Nanomaterials

10.1021/acsami.1c00083

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Citations (111)

Quaternary ammonium substituted dextrin‐based biocompatible cationic nanoparticles with ultrahigh pH stability for drug delivery

Journal of Applied Polymer Science (2023)

Ankita Sarkar Shounak Roy Prachi Bhatia Amit Jaiswal

Abstract Cationic nanoparticles (NPs) are preferred for therapeutic applications due to its better uptake by mammalian cells. However, preparing cationic polymeric NPs with stability in wide pH range along with limited toxicity remains a challenge. Dextrin, a carbohydrate‐based natural biological macromolecule holds great potential in biomedical applications. Further, it is an inexpensive and abundant raw material which has high pH stability making it more advantageous over other widely explored macromolecules like chitosan. Herein, we report a simple process for preparing biocompatible cationic dextrin (CD) NPs. A series of CDs were prepared through a single‐step reaction by incorporating quaternary ammonium groups onto the polymeric backbone using varying amount of glycidyltrimethylammonium chloride. Formation of uniform spherical CD NPs having size within 100 nm were achieved by a facile synthesis process of ionic gelation using a biocompatible cross‐linker sodium tripolyphosphate. The prepared CD NPs remained stable across the pH range of 5.5–11 and demonstrated approximately 75% cellular internalization within 6 h. The CD NPs were also found to be both cytocompatible and hemocompatible. Next, the chemotherapeutic drug doxorubicin was encapsulated within CD NPs, which is one of the most common chemotherapeutic agents used for the treatment of various types of cancers including breast, lung, ovarian and bladder. The Dox‐loaded CD NPs showed better drug release at acidic pH conditions and induced more than 80% cell death within 24 h at just 2 μg/ml concentration when tested against HeLa cell lines, thus, proving to be a potential drug delivery vehicle for cancer therapy applications.

Dextrin

Cationic polymerization

HeLa

Linker

10.1002/app.53626

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Citations (3)