Wei Su

Hebei University of Science and Technology

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Peiyuan Li

Guangxi University

Qi Xiao

University of Pennsylvania

Qijin Zhang

Changchun University of Science and Technology

Shan Huang

China University of Petroleum, East China

Tian‐Jun Gong

University of Science and Technology of China

Xiaolin Lei

North China University of Water Resources and Electric Power

Yao Fu

CAS Key Laboratory of Urban Pollutant Conversion

Bin Xiao

University of Science and Technology of China

Chusheng Huang

Nanning Normal University

Quanquan Qian

Hubei University of Chinese Medicine

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Chinese Academy of Sciences

106

University of Science and Technology of China

University of Chinese Academy of Sciences

Central South University

Sun Yat-sen University

Peking University

Shandong University

Collaborative Innovation Center of Chemistry for Energy Materials

Nanning Normal University

University of Science and Technology Beijing

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CCDC 860113: Experimental Crystal Structure Determination

The Cambridge Structural Database (2013)

Wei Su Quanquan Qian Peiyuan Li Xiaolin Lei Qi Xiao

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.

10.5517/ccxw0lc

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CCDC 1510895: Experimental Crystal Structure Determination

The Cambridge Structural Database (2017)

Wei Su Xiaohui Wang Xiaolin Lei Qi Xiao Shan Huang

10.5517/ccdc.csd.cc1mq6k3

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Prostate Cancer-Secreted Exosomal miR-1275 Modulates Osteoblast Proliferation and Differentiation by Targeting SIRT2/RUNX2 Cascade

Research Square (Research Square) (2020)

Zihao Zou Ranran Dai Nan Deng Wei Su Ping Liu

Abstract BackgroundCancer-derived exosomes can promote tumor metastasis by delivering miRNAs from cancer cells to recipient cells. miR-1275 is suggested to be an important regulator involved in prostate cancer (PCa) metastasis; however, the association of miR-1275 with the microenvironment of PCa bone metastasis is unclear.Materials and methodsThe level of relative genes and proteins were detected by qPCR and western-blot, cell ability were examined by CCK-8 , the identification of target gene was analyzed by dual-luciferase reporter assay,exosomes were isolated from the PC3-derived conditioned medium by ultracentrifugation.Resultwe found that miR-1275 could be transferred from PCa cells to osteoblasts via exosomes. Exosomal miR-1275 significantly accelerated the proliferation of osteoblasts and the expression levels of osteoblast-specific genes, such as osteocalcin (OCN), type I collagen (COL-1), and osteopontin (OPN). Moreover, exosomal miR-1275 increased the expression of RUNX2, a master modulator of osteoblast differentiation, by down-regulation of SIRT2, which in turn influenced the proliferation and differentiation of osteoblasts.ConclusionsOur findings indicate that exosomal miR-1275 is a promoter of osteoblast activity, which may contribute to PCa bone metastasis.

Osteopontin

RUNX2

Exosome

10.21203/rs.3.rs-78100/v1

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Dual hollow-core anti-resonant fiber polarization beam splitter with excellent single-mode characteristics for ultra-broadband

Applied Physics B (2023)

Jingkai Zhou Yan Lu Anying Jiang Yu Chen Jianjie Xu

Beam splitter

Splitter

Extinction ratio

Mode volume

10.1007/s00340-023-08098-5

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Mechanism of Ligand‐Controlled Regioselectivity‐Switchable Copper‐Catalyzed Alkylboration of Alkenes

Chemistry - A European Journal (2016)

Zheng‐Yang Xu Yuan‐Ye Jiang Wei Su Haizhu Yu Yao Fu

Abstract Cu‐catalyzed alkylboration of alkenes with bis(pinacolato)diboron ((Bpin) 2 ) and alkyl halides provides a ligand‐controlled regioselectivity‐switchable method for the construction of complex boron‐containing compounds. Here, we employed DFT methods to elucidate the mechanistic details of this reaction and the origin of the different regioselectivity induced by Xantphos and Cy‐Xantphos. The calculation results reveal that the catalytic cycle mainly proceeds through the migratory insertion of alkenes on Cu‐Bpin complex, the oxidative addition of alkyl halides, and the reductive elimination of a C−C bond. Meanwhile, the rate‐ determining step is the oxidative addition of alkyl halides and the regioselectivity‐determining step is the migratory insertion of alkenes. The bulky cyclohexyl group of Cy‐Xantphos facilitates the approach of the substituents of alkenes to Bpin in the migratory insertion step and thus leads to the Markovnikov products. The less bulky phenyl group on Xantphos prefers keeping the substituents of alkenes away from the Bpin moiety in the migratory insertion step and thus results in anti ‐Markovnikov products.

Xantphos

Markovnikov's rule

Oxidative addition

Reductive elimination

10.1002/chem.201602610

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Citations (40)

Properties of Eu chelate doped polymer thin film

Materials Letters (2005)

H. Liang Biao Chen Jie Xu Wei Su Fuquan Guo

Waveguide

Spin Coating

10.1016/j.matlet.2005.07.058

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Study on variation of moisture in lobster sauce during fermentation by nuclear magnetic resonance

Science and Technology of Cereals,oils and Foods (2014)

Wei Su

Nuclear magnetic resonance( NMR) transverse relaxation time( T2) reflects the hydrogen proton component and motility in fermented soybean products with different fermentation time,and it was used to discover the variation of moisture in fermented soybean products. The T2 signal of fermented soybean was collected by PQ001 analysis software and CPMG( Carr Purcell meiboom- gill) sequence to obtain T2 spectrum. The spectrum showes that the hydrogen proton in fermented soybean roughly divided into four phases: T21( 0. 01~ 1. 52 ms),T22( 1. 52~ 7. 05 ms),T23( 7. 05~ 100 ms) and T24( 100 ms). Through the component content analysis,along with the anaerobic fermentation,decomposition of protein- based materials by microbial enzymes,metabolic activity of microorganisms and the formation of flavor substances,the combined water reduced continuously. There was a process of mutual transformation of water in cells( T22 and T23),and the content of free water also decreased in a certain extent. During the fermentation,the umami ingredients increased largely,amino nitrogen improved significantly,flavor substances increased significantly,the color of soften soybean deepened. NMR method can indirectly reflect the formation of the flavor and the change in texture and other index during fermentation.

Source

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Banded texture of photo-aligned azobenzene-containing side-chain liquid crystalline polymers

Polymer (2004)

Jian Liu Kai Sun Zenchang Li Jiangang Gao Wei Su

Texture (cosmology)

Azobenzene

Side chain

Methylene

Polarized light microscopy

10.1016/j.polymer.2004.04.003