Disrupted organ growth underlies the development of several diseases. Whereas the fetal heart grows mainly through proliferation, the postnatal heart grows through hypertrophy. Hypertrophy is also activated in the adult heart as a compensatory response to stress, but chronic ventricular hypertrophy leads to heart failure. The molecular mechanisms underlying ventricular hypertrophy are unknown. We show that cardiac expression and activation of p38γ and p38δ increases during postnatal development and these kinases are activated by the hypertrophy-inducing stress stimuli angiotensin II and phenylephrine. p38γ and p38δ promote cardiac hypertrophy by phosphorylating the mTORC1 and mTORC2 inhibitor DEPTOR, promoting its degradation and thereby activating mTORC1 and mTORC2. Hearts from mice lacking one or both kinases were below-normal size, had high levels of DEPTOR and consequently low activity of the mTOR pathway, and reduced protein synthesis. The mTOR inhibitor, rapamycin, equalized heart weight in wild-type and p38γ/δ-/- mice. Moreover, p38γ/δ-/- mice were protected against pathological ventricular hypertrophy, establishing p38γ/δ as key regulators of this process.

mTORC2

10.1161/res.117.suppl_1.348

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WSC 09 ‐ Inflammatory and Fibrotic Lung Diseases

European Journal of Immunology (2009)

Karline Guilloteau Isabelle Pâris Nathalie Pedretti Katia Boniface Franck Juchaux

Abstract No Abtract

10.1002/eji.200990200

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Resonancia magnética para portadores de dispositivos cardiovasculares. Consenso SEC-GT CRMTC/SEC-Asociación del Ritmo Cardiaco/SERAM/SEICAT

Revista Española de Cardiología (2022)

Manuel Barreiro‐Pérez Beatriz Cabeza David Calvo José Luís Reyes-Juárez Tomás Datino

10.1016/j.recesp.2022.09.010

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Citations (5)

Magnetic resonance in patients with cardiovascular devices. SEC-GT CRMTC/SEC-Heart Rhythm Association/SERAM/SEICAT consensus document

Radiología (English Edition) (2023)

Manuel Barreiro‐Pérez Beatriz Cabeza David Calvo José Luís Reyes-Juárez Tomás Datino

Heart Rhythm

Cardiac magnetic resonance

10.1016/j.rxeng.2022.09.014

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Citations (3)

Electrocardiographic biomarkers to predict atrial fibrillation in sinus rhythm electrocardiograms

Heart (2021)

Ancor Sanz‐García Alberto Cecconi Alberto Vera Juan M. Camarasaltas Fernándo Alfonso

Objective Early prediction of atrial fibrillation (AF) development would improve patient outcomes. We propose a simple and cheap ECG based score to predict AF development. Methods A cohort of 16 316 patients was analysed. ECG measures provided by the computer-assisted ECG software were used to identify patients. A first group included patients in sinus rhythm who showed an ECG with AF at any time later (n=505). A second group included patients with all their ECGs in sinus rhythm (n=15 811). By using a training set (75% of the cohort) the initial sinus rhythm ECGs of both groups were analysed and a predictive risk score based on a multivariate logistic model was constructed. Results A multivariate regression model was constructed with 32 variables showing a predictive value characterised by an area under the curve (AUC) of 0.776 (95% CI: 0.738 to 0.814). The subsequent risk score included the following variables: age, duration of P-wave in aVF, V4 and V5; duration of T-wave in V3, mean QT interval adjusted for heart rate, transverse P-wave clockwise rotation, transverse P-wave terminal angle and transverse QRS complex terminal vector magnitude. Risk score values ranged from 0 (no risk) to 5 (high risk). The predictive validity of the score reached an AUC of 0.764 (95% CI: 0.722 to 0.806) with a global specificity of 61% and a sensitivity of 55%. Conclusions The automatic assessment of ECG biomarkers from ECGs in sinus rhythm is able to predict the risk for AF providing a low-cost screening strategy for early detection of this pathology.

10.1136/heartjnl-2021-319120

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Optical Method to Asses Ex-Vivo the Extent of Atherosclerosis in Mouse Aortas

Biophysical Journal (2013)

Susana A. Sánchez Nerea Méndez‐Barbero Antonio M. Santos-Beneit Vanesa Esteban Vázquez Luis Jesús Jiménez‐Borreguero

Atheroma

Coronary arteries

Ex vivo

Arteriosclerosis

Foam cell

10.1016/j.bpj.2012.11.1884

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Association Between a Social-Business Eating Pattern and Early Asymptomatic Atherosclerosis

Journal of the American College of Cardiology (2016)

José L. Peñalvo Leticia Fernández‐Friera Beatriz López‐Melgar Irina Uzhova Belén Oliva

The importance of a healthy diet in relation to cardiovascular health promotion is widely recognized. Identifying specific dietary patterns related to early atherosclerosis would contribute greatly to inform effective primary prevention strategies. This study sought to quantify the association between specific dietary patterns and presence and extent of subclinical atherosclerosis in a population of asymptomatic middle-aged adults. The PESA (Progression of Early Subclinical Atherosclerosis) study enrolled 4,082 asymptomatic participants 40 to 54 years of age (mean age 45.8 years; 63% male) to evaluate the presence of subclinical atherosclerosis in multiple vascular territories. A fundamental objective of this cohort study was to evaluate the life-style–related determinants, including diet, on atherosclerosis onset and development. We conducted a cross-sectional analysis of baseline data, including detailed information on dietary habits obtained as part of the overall life-style and risk factor assessment, as well as a complete vascular imaging study that was performed blinded to the clinical information. Most PESA participants follow a Mediterranean (40% of participants) or a Western (41%) dietary pattern. A new pattern, identified among 19% of participants, was labeled as a social-business eating pattern, characterized by a high consumption of red meat, pre-made foods, snacks, alcohol, and sugar-sweetened beverages and frequent eating-out behavior. Participants following this pattern presented a significantly worse cardiovascular risk profile and, after adjustment for risk factors, increased odds of presenting subclinical atherosclerosis (odds ratio: 1.31; 95% confidence interval: 1.06 to 1.63) compared with participants following a Mediterranean diet. A new social-business eating pattern, characterized by high consumption of red and processed meat, alcohol, and sugar-sweetened beverages, and by frequent snacking and eating out as part of an overall unhealthy life-style, is associated with an increased prevalence, burden, and multisite presence of subclinical atherosclerosis. (Progression of Early Subclinical Atherosclerosis [PESA]; NCT01410318)

Subclinical infection

Mediterranean Diet

10.1016/j.jacc.2016.05.080

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Citations (28)

Quantification of blood flow in great vessels from cardiac magnetic resonance imaging

International symposium on image and signal processing and analysis/ISPA ... (2005)

María J. Ledesma‐Carbayo Carmen Montejo Norberto Malpica Luis Jesús Jiménez‐Borreguero A. Santos

This paper presents a new fool developed to quantify and characterize blood flow in great vessels. The aim is to quantify the flow during the cardiac cycle from sequences of magnetic resonance images of the vessel cross-section. The proposed method tracks the vessel contour to automatically quantify the maximum velocity and flow through the cardiac cycle and finally obtains the instantaneous stroke volume. The techniques proposed are based on active contours coupled with a motion estimation method. Results in ten different sequences from patients and healthy subjects have been obtained, showing values similar to other flow measurement techniques. A repeatability study was done to assess the robustness of the proposed tool.

Cardiac cycle

Robustness

Repeatability

Cardiac magnetic resonance

10.1109/ispa.2005.195397

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Citations (1)