Emergency Logistics is a hot issue, meanwhile, emergency logistics of enterprises also is an important aspect. This paper focuses on the distribution business decision-making of enterprises based on emergency logistics. In the case of unexpected incidents this paper holds that there are three features in the emergency supplies distribution. They are dynamic supply demand for emergency supplies, the lack of transport vehicles and carriers and companies who try to complete tasks under the premise of contingency in order to make profit. Based on these three features, the dynamic distribution and its plan are discussed in detail, and so does the dynamic planning model. Under the premise of time requirements, the goal of this distribution scheme is the lowest cost path. Then, this paper uses fuzzy programming to acquire distribution plan. In addition, this paper discusses the emergency supplies of outsourcing decision-making.
Tumor-derived extracellular vesicles (EVs) are key immune regulators of the tumor microenvironment. They reshape the immune microenvironment and prevent antitumor immune responses via their immunosuppressive cargo, thereby determining cancer responsiveness to treatment. In the immune microenvironment of melanoma, tumor-derived EVs influence tumor progression by regulating innate and adaptive immune responses. Tumor-derived EV-based therapy is a cutting-edge and promising strategy for inhibiting melanoma progression and enhancing antitumor immunity. This review aimed to summarize the regulatory roles of EVs in the immune responses and immunotherapy of patients with melanoma. This paper provided insights into future exploration directions and potential clinical strategies targeting EVs for melanoma treatment.
Abstract Aiming at the problems of traditional centrifugal pump mechanical bearing, short life, low speed, and difficulty solving of motion sealing, it is carried out to adapt to the design of electromagnetic bearing design that is suitable for liquid work quality and high pressure, and the rationality of the structural design is verified through electromagnetic field simulation and experimental testing. The results show that: (1) Through electromagnetic field simulation analysis of electromagnetic bearings, under a working gap of 0.3 mm and a working current of 2 A, the electromagnetic force is 129.7 N, meeting the bearing capacity requirement of 124 N; (2) Through simulation analysis of the magnetic field of electromagnetic bearings under different pole arrangements, to reduce the mutual coupling between magnetic circuits, the radial electromagnetic bearings should adopt a circumferential NSSN pole arrangement; (3) Through the analysis of the impact of working current on the performance of electromagnetic bearings, when the current is below 1.8 A, the electromagnetic force is proportional to the square of the current; when the current increases from 1.8 A to 3 A, the electromagnetic force is not obvious with the increase of current, showing nonlinear characteristics. Therefore, when designing the electromagnetic bearing, the maximum magnetic induction intensity selected is generally the critical point of the linear interval, so that the electromagnetic bearing works in the linear interval.
A novel near-infrared phosphorescent iridium(iii) complex was developed for fast and highly specific peroxynitrite detection through the use of time-resolved emission spectra.
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