Sebastián Dankert

University of Warmia and Mazury in Olsztyn

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Rafael Iribarren

Favaloro Foundation

J. Rozema

Antwerp University Hospital

Carla Lança

New York University

Andrzej Grzybowski

University of Warmia and Mazury in Olsztyn

Guillermo Saracco

Centro de Investigaciones Cardiovasculares

Abel Szeps

Hospital Posadas

Seang‐Mei Saw

National University of Singapore

Yanhui Dong

Peking University

Pushpaja Vasudevan

Indira Gandhi Medical College and Research Institute

Kate Gifford

University of Colorado Boulder

Cooperative Institutions

University of Warmia and Mazury in Olsztyn

Charité - Universitätsmedizin Berlin

Universidade Nova de Lisboa

Instituto Politécnico de Lisboa

Hospital Posadas

Singapore National Eye Center

National University of Singapore

Sun Yat-sen University

Singapore Eye Research Institute

Wenzhou Medical University

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Hot Topics in Dry Eye Disease

Current Pharmaceutical Design (2017)

Andrzej Grzybowski Marcos Mendaro Sebastián Dankert Luis Alberto Zeman Bardeci Pablo Chiaradía

Dry eye disease (DED) is a multifactorial disease of the tears and ocular surface that results in symptoms such as discomfort, visual disturbance, and tear film instability, with potential damage to the ocular surface. The principal pathological mechanisms of DED are hyperosmolarity and inflammation. These mechanisms are deeply interrelated and lead to a self-perpetuating "vicious circle".The objective of this review is to describe novel pharmacological and non-pharmacological treatments for DED.Based on the better understanding of the physiopathology of the disease, new treatment strategies have been developed.The focus of the management of DED has been taken away from just reducing symptoms and redirected towards specific targets of its physiopathology, being inflammation the most addressed topic.

Pathophysiology

Artificial tears

10.2174/1381612822666161208094841

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Citations (10)

Axial Growth and Lens Power Loss at Myopia Onset in Singaporean Children

Investigative Ophthalmology & Visual Science (2019)

J. Rozema Sebastián Dankert Rafael Iribarren Carla Lança Seang‐Mei Saw

Purpose: We studied biometry changes before and after myopia onset in a cohort of Singaporean children. Methods: All data were taken from the Singapore Cohort Study of the Risk Factors for Myopia (SCORM). Participants underwent refraction and biometry measurements with a follow-up of 3 to 6 years. The longitudinal ocular biometry (spherical equivalent refraction, axial length, and lens power) changes were compared between children who suffered myopia during the study (N = 303), emmetropic children (N = 490), and children myopic at baseline (N = 509). Results: At myopia onset, the myopic shift increased to 0.50 diopters (D)/y or more in new myopes compared to the minor changes in emmetropes of the same age. New myopes had higher axial growth rates than emmetropes, even years before myopia onset (0.37 and 0.14 mm/y, respectively; ANOVA with Bonferroni post hoc test, P < 0.001). After onset, the change in both parameters slowed down gradually, but significantly (P < 0.05). In new myopes, lens power loss (−0.71 D/y) was significantly higher up to 1 year before myopia onset compared to emmetropes (−0.46 D/y), after which lens power loss slows down rapidly. At age 7 years, (future) new myopes had lens power values close to those of emmetropes (25.12 and 25.23 D, respectively), while later these values approached those of children who were myopic at baseline (23.06 and 22.79 D, respectively, compared to 23.71 D for emmetropes; P < 0.001). Conclusions: New myopes have higher axial growth rates and lens power loss before myopia onset than persistent emmetropes.

Emmetropia

10.1167/iovs.18-26247

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Citations (108)

Myopia: Public Health Challenges and Interventions

Frontiers research topics (2022)

Carla Lança Andrzej Grzybowski Rafael Iribarren Lixia Tao Chunxiao Wang

Frontiers is more than just an open-access publisher of scholarly articles: it is a pioneering approach to the world of academia, radically improving the way scholarly research is managed.The grand vision of Frontiers is a world where all people have an equal opportunity to seek, share and generate knowledge.Frontiers provides immediate and permanent online open access to all its publications, but this alone is not enough to realize our grand goals. Frontiers Journal SeriesThe Frontiers Journal Series is a multi-tier and interdisciplinary set of open-access, online journals, promising a paradigm shift from the current review, selection and dissemination processes in academic publishing.All Frontiers journals are driven by researchers for researchers; therefore, they constitute a service to the scholarly community.At the same time, the Frontiers Journal Series operates on a revolutionary invention, the tiered publishing system, initially addressing specific communities of scholars, and gradually climbing up to broader public understanding, thus serving the interests of the lay society, too. Dedication to QualityEach Frontiers article is a landmark of the highest quality, thanks to genuinely collaborative interactions between authors and review editors, who include some of the world's best academicians.Research must be certified by peers before entering a stream of knowledge that may eventually reach the public -and shape society; therefore, Frontiers only applies the most rigorous and unbiased reviews.Frontiers revolutionizes research publishing by freely delivering the most outstanding research, evaluated with no bias from both the academic and social point of view.By applying the most advanced information technologies, Frontiers is catapulting scholarly publishing into a new generation.

Public Health Interventions

10.3389/978-2-83250-356-0

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Differences in ocular biometry between urban and rural children matched by refractive error: the Shandong Children Eye Study

Ophthalmic and Physiological Optics (2019)

J. Rozema Wei Sun Jian Wu Wen Jiang Hui Wu

Abstract Purpose To determine the differences in mean ocular dimensions between urban and rural children and identify possible influencing factors. Methods This work uses previously published data from the Shandong Children Eye Study, which was based on a random cluster sampling applied to a cross‐sectional school‐based study design in the rural Guanxian County and Weihai city. All children underwent auto‐refractometry and biometry under cycloplegia. Results The study included 3290 children (aged 9.35 ± 2.93 years), consisting of 888 pairs of boys and 757 pairs of girls matched by sex, age and refractive error (each pair matching one child from urban cohort with one from the rural cohort). Overall urban children were significantly taller and heavier than rural children ( t ‐test; p < 0.001), which was confirmed for all age groups for weight. Urban ocular axial lengths were significantly longer by 0.23 mm compared to the rural population ( t ‐test; p < 0.001), mostly in younger children and boys. Meanwhile, corneal curvatures were flatter in the urban cohort by 0.08 mm ( p < 0.001). This association of axial length with urban vs rural region was reduced in magnitude by 69.7% after accounting for height. Conclusions For the same, matched refractive error, children from urban regions had significantly longer eyes and flatter corneal curvature than rural children. Since corneal curvature is defined during the first 2 years of life, early environmental factors may be the source of these differences in ocular dimensions.

10.1111/opo.12649

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Citations (14)

A pilot study of axial length changes associated with myopia control spectacles in subjects reading under mesopic conditions

Journal of American Association for Pediatric Ophthalmology and Strabismus (2024)

Abel Szeps Sebastián Dankert Guillermo Saracco Rafael Iribarren

Mesopic vision

10.1016/j.jaapos.2024.103857

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Citations (5)

Emmetropization and nonmyopic eye growth

Survey of Ophthalmology (2023)