CY Xiao

Jiangxi University of Traditional Chinese Medicine

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XX Zhai

Jiangxi University of Traditional Chinese Medicine

QH Lin

Jiangxi University of Traditional Chinese Medicine

WJ Yuan

Jiangxi University of Traditional Chinese Medicine

Gang Ren

Jiangxi University of Traditional Chinese Medicine

WF Yi

Jiangxi University of Traditional Chinese Medicine

X. Y. Gong

X. Hu

New York University

Zhang Xx

Zoucheng People's Hospital

Guangxiang Ren

Jiangxi University of Traditional Chinese Medicine

XC Wu

World Wide Web Consortium

Cooperative Institutions

Jiangxi University of Traditional Chinese Medicine

Sichuan Agricultural University

Chinese Academy of Medical Sciences & Peking Union Medical College

Nankai University

New York University

National Space Science Center

Chinese Academy of Sciences

Zoucheng People's Hospital

Dalian Neusoft University of Information

Beijing Children’s Hospital

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Prenylated 2-Arylbenzofurans From Artorpus Styracifolius

Planta Medica (2016)

Gang Ren QH Lin WF Yi WJ Yuan Jian‐Xin Zhu

Artorpus styracifolius Pierre, arbor of the genus Artocarpus (Moraceae), is mainly distributed in several southern provinces of China and is also called “Hongfenghe”. The root of A. styracifolius was used to treat disease in folk medicine. In this study, two new prenylated 2-arylbenzofurans, namely astostyracins D and E (1 – 2, resp), together with a known one (3), were isolated from the root of A. styracifolius. Their structures were determined by spectroscopic methods (1D and 2D NMR, UV, IR, and HR-ESI-MS). These compounds will be tested for their inhibitory effect on Cathepsin K.

Moraceae

Folk medicine

10.1055/s-0036-1578770

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Prenylated Stilbenes From Artocarpus Styracifolius

Planta Medica (2016)

Gang Ren WF Yi JW He WJ Yuan M Li

Artocarpus styracifolius Pierre (Moraceae), an evergreen arbor tree distributed in the southern part of China, is traditionally used in folk medicine for the treatment of rheumatoid arthritis, psoatic strain, hemiplegia and fracture [1]. A series of isoprenoid-substituted phenolic compounds, including flavonoids and 2-arybenzofurans, has been reported from the various parts of the plant [2 – 3]. In the present study, a re-examination of the 95% EtOH extract of the root barks of this plant provided four unusual isoprenylated stilbene derivatives 1 – 4, together with five known stilbenes 5 – 9. Their structures were determined by spectroscopic methods (1D and 2D NMR, CD, UV, IR, and HR-ESI-MS). In addition, the possible biosynthetic pathway for these compounds was proposed.

Moraceae

Artocarpus

10.1055/s-0036-1578769

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Flavonoids From The Roots Of Artocarpus Heterophyllus And Their Inhibitory Activity Against Cathepsin K

Planta Medica (2016)

Guangxiang Ren WJ Yuan Y M Zhang XX Zhai QH Lin

As part of our project for discovering structurally interesting and bioactive phenolic compounds from Artocarpus plants (Moraceae), we performed a phytochemical investigation on Artocarpus heterophyllus. Four new flavonoids, artoheteroids A-D (1 – 4) were isolated from the roots of this plant. The structures were elucidated by spectroscopic methods, including 1D and 2D NMR, UV, IR, CD, and HR-ESI-MS. All the isolates (1 – 4) were evaluated for their inhibitory activity against Cathepsin K, and compounds 1 – 3 exhibited significantly suppressive effect on Cathepsin K with IC50 values of 6.03, 12.52, 13.65µM, respectively.

Artocarpus

Moraceae

Phytochemical

IC50

Nutraceutical

10.1055/s-0036-1578768

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Mountain-based GPS observations of occultation and its inversion theory

X. Hu Zhang Xx XC Wu CY Xiao Zhen Zeng

Mountain-based GPS radio occultation observations were conducted at the Yaogu mountain and Jiugong mountain in Hubei province, respectively. Occultation event data were successfully obtained. Analysis and statistics of the occultation events have been completed. The principle and methods estimating bending angles of the radio rays and atmospheric refractivity profiles with the mountain-based radio occultation data are given. The simulation data of mountain-based occultation events are used for testing the inversion method. Testing results show that the inversion method is efficient. The atmospheric refractivity profiles below the height of the GPS receiver are obtained with this inversion technique, as well as the bending angle of rays. The results suggest that the mountain-based occultation technique is a potential new method for monitoring lower atmospheric environments.

Radio occultation

Occultation

Inverse transform sampling

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