T Yamada

Gunma University

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STUDIES ON THE CELLULAR-IMMUNITY ACCORDING TO THE GRADE OF HISTOLOGICAL DEPTH OF INVASION IN GASTRIC CARCINOMA

Kitakantou igaku/Kitakantō Igaku (1991)

M Takeshita Tooru WATANABE T Yamada Isao Kobayashi Seiji Nakamura

We investigated cellular immunity and the sate of metastasis to lymph nodes according to the depth of invasion in gastric carcinoma.Skin tests (PHA, Su-PS, PPD), blastoformation (PHA, PWM) and T cell subsets (OKT 3, 4, 8, 4/8, Leu 11, 7) in peripheral blood and regional lymph nodes were evaluated.In patients with carcinoma invading from the mucosa to the submucosa, skin tests, the number of T cell subsets, and blastformation were not depressed in peripheral blood and lymph nodes.However cellular immunity was decreased and the rate of metastasis to lymph nodes was increased according to the invasion of carcinoma.

Submucosa

Gastric carcinoma

Cervical lymph nodes

Cellular immunity

10.2974/kmj1951.41.199

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(E11102) The Effect of the protein intake on the performance of exercises in-vivo :

Advances in exercise and sports physiology (1999)

Kazuhiro Suzukawa Hiromitsu Tani Manami Kaneko Takayoshi Ohnishi Katsumi Sugiura

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Role of protein phosphatase in malignant osteogenic and soft tissue tumors.

PubMed (1996)

Kenichi Sogawa T Yamada Ai Sugita Kuniyoshi Kito M. Tachibana

The expression of the three catalytic subunits of protein phosphatase (PP) type 1 and 2A, PP1 alpha, PP1 gamma 1, and PP2AC, was examined in osteogenic tumors and soft tissue tumors by immunohistochemical analysis. The percentage of cells stained positively with antiserum against PP1 catalytic subunit isoform PP1 gamma 1, was significantly higher in malignant osteogenic tumors (chondrosarcoma, osteosarcoma, and Ewing's sarcoma) and in malignant soft tissue tumors (liposarcoma and malignant fibrous histiocytoma [M.F.H.]) than in benign tumors (osteochondroma, osteoblastoma, ossifying fibroma, enchondroma and lipoma). Furthermore, the malignant tumor lesions showed a markedly high number of cells in the S-phase fraction of the cell cycle, as compared to benign tumors. These results suggest that PP1 gamma 1 is involved in the accelerated growth of malignant tumor cells.

Enchondroma

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Clinical evaluation of Minocycline in oral infectious disease

Japanese Journal of Oral & Maxillofacial Surgery (1972)

Masaru Nagayama Akira Takahashi Goro HIBI S Shibata Toru IKE

Minocycline

10.5794/jjoms.18.211

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[Gastric lymphosarcoma associated with early carcinoma (type IIa)--a case report].

PubMed (1984)

Shinichiro Sawa Yukimitsu Kawaura Mitsuyasu Hirano T Yamada Takashi Iwa

We report a case of gastric lymphosarcoma associated with early carcinoma (type IIa). Lymphosarcoma was also seen in the small intestine, but there were no metastatic lesions in the lymph nodes , liver, and peritoneum. This suggest that lymphosarcoma was the primary cancer in both the stomach and small intestine. Microscopically, the early carcinoma was a moderately differentiated tubular adenocarcinoma . Only two earlier cases of coexistent gastric lymphosarcoma and early gastric carcinoma have been reported in the literature.

Gastric carcinoma

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Skin metastasis from the spindle cell component in rectal carcinosarcoma.

PubMed (2001)

Izumi Takeyoshi Miho Yoshida Sae Ohwada T Yamada A Yanagisawa

Carcinosarcomas are rare tumors, which are usually composed of carcinomatous areas close to or intermixed with sarcomatous components. Only 6 cases of carcinosarcoma of the colon have been reported in the English literature previously. We describe the 7th case, an 82-year-old man with a skin metastasis from the spindle cell component of a rectal carcinosarcoma. On rectal exploration, a large, firm tumor was palpated 2 cm from the anal verge. Endoscopic examination revealed a tumor projecting into the lumen, and hemorrhage from the tumor surface. We performed a low anterior resection. The resected specimen contained an ulcerative lesion with a round wall in continuity with a papillary tumor. Carcinoma and sarcoma components existed concomitantly along with transitional features. Immunohistochemistry disclosed immunoreactivity for vimentin in most of the spindle cell areas. Carcinoembryonic antigen was positive in the adenocarcinomatous component. One month after surgery, the patient developed a skin metastasis on the back. The skin biopsy specimen contained proliferating spindle cells almost identical to those of the primary lesion. The patient died of carcinosarcoma 6 months after surgery. In this paper, we review 7 cases of colorectal carcinosarcoma, including our patient, who is only the 7th such reported case.

Carcinosarcoma

Spindle cell carcinoma

Spindle cell sarcoma

Carcinoembryonic antigen

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Citations (23)