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Alice Ameline

Institut de Médecine et d'Epidémiologie Africaines

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Pascal Kintz

Institut de Médecine et d'Epidémiologie Africaines

Jean‐Sébastien Raul

Université de Strasbourg

Laurie Gheddar

Institut de Médecine et d'Epidémiologie Africaines

Nadia Arbouche

Institut de Médecine et d'Epidémiologie Africaines

Emilie Feisthauer

Institut de Médecine et d'Epidémiologie Africaines

Adeline Blanchot

Université de Strasbourg

Jean‐Michel Gaulier

IMPact de l'Environnement Chimique sur la Santé humaine

Frédéric Aknouche

Synerlab (France)

Audrey Farrugia

Université de Strasbourg

J Huguier

Cooperative Institutions

Inserm

Centre National de la Recherche Scientifique

Institut de Médecine et d'Epidémiologie Africaines

Aix-Marseille Université

Assistance Publique – Hôpitaux de Paris

Université de Strasbourg

Hôpital de la Timone

Université Paris Cité

Centre Hospitalier Universitaire de Lille

Assistance Publique Hôpitaux de Marseille

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The use of multiple keratinous matrices (head hair, axillary hair, and toenail clippings) can help narrowing a period of drug exposure: experience with a criminal case involving 25I-NBOMe and 4-MMC

International Journal of Legal Medicine (2021)

Pascal Kintz Jean‐Sébastien Raul Alice Ameline

Hair analysis

Illicit drug

Pubic hair

10.1007/s00414-021-02511-4

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Citations (7)

[Streptomycin in surgical forms of genital tuberculosis].

Genital tuberculosis

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Citations (1)

[The rectum and pelvic colon in gynecology].

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The use of saline, bicarbonate, hyposulfite in the prevention of operative shock.

Bicarbonate

Sodium bicarbonate

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Décès toxique par ingestion combinée de métoprolol et de lacosamide

Annales de Toxicologie Analytique (2017)

Ysé Sauvageon Pascal Kintz N. Dupuis Alice Ameline L. Rousseau

Lacosamide

10.1016/j.toxac.2017.03.124

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Citations (1)

Intérêt de rechercher la 4-ANPP dans les milieux biologiques comme marqueur d’une exposition au fentanyl ou à un analogue structural

Annales de Toxicologie Analytique (2021)

Emilie Feisthauer Audrey Farrugia Alice Ameline Laurie Gheddar Nadia Arbouche

10.1016/j.toxac.2021.06.003

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Identification in vitro des métabolites du protonitazène par microsomes hépatiques humains, et comparaison ultérieure avec des échantillons urinaires issus de deux intoxications mortelles

Annales de Toxicologie Analytique (2024)

Alice Ameline Laurie Gheddar Christophe Maruéjouls Frédéric Aknouche Nadia Arbouche

10.1016/j.toxac.2024.09.004

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Testing for betel nut alkaloids in hair using UHPLC-MS/MS and UHPLC-Q-ToF-MS

Annales de Toxicologie Analytique (2019)

Laurie Gheddar François‐Xavier Ricaut Alice Ameline Emilie Feisthauer Nicolas Brucato

Areca

Betel

Arecoline

Catechu

10.1016/j.toxac.2019.03.020

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Mort d’un nouveau-né en pouponnière : l’hydroxyzine mise en cause ?

Annales de Toxicologie Analytique (2019)

F. Aknouche C. Maruejouls C. Mazoyer W. Gasnot F. Pellegrino

10.1016/j.toxac.2019.03.032

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Perspectives in Evaluating Selective Androgen Receptor Modulators in Human Hair: A Short Communication

Therapeutic Drug Monitoring (2020)

Pascal Kintz Laurie Gheddar Alice Ameline Jean‐Sébastien Raul

As hair testing increases the window of drug detection and permits the differentiation of long-term use from a single exposure when performing segmental analyses (which also allows establishing the pattern of use), this matrix should be considered as a suitable complement to standard investigations in clinical, forensic, and sport toxicology. The authors were recently involved in 3 cases where hair analysis was used to demonstrate the use of selective androgen receptor modulators (SARMs), including ligandrol (LGD-4033), andarine (S-4), and ostarine (S-22). SARMs are increasingly being abused as "safe" alternatives to steroids.After decontamination using dichloromethane, hair specimens were segmented, cut into very small segments (<1 mm), incubated overnight in a buffer, and extracted using a mixture of organic solvents. Drugs were tested using liquid chromatography-tandem mass spectrometry and confirmed using liquid chromatography/HRMS.The determined concentrations were as follows: ligandrol, 14-42 pg/mg; andarine, 0.1-0.7 pg/mg; and ostarine, 3-21 pg/mg.To enhance performance, SARMs must be used on a long-term basis, which can have serious clinical consequences, including liver damage, myocardial infarction, and blood clots. Hair testing for SARMs has additional benefits versus urine analysis as it can detect the parent compound and numerous metabolites.

Hair analysis

Orbitrap

10.1097/ftd.0000000000000859

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Citations (8)

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