Dragica Milosavljević

University of Belgrade

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J. Milivojević

University of Belgrade

Vuk Maksimović

Institute for Multidisciplinary Research

Jelena Dragišić Maksimović

Institute for Multidisciplinary Research

Tomislav Kažić

Telekom Srbija (Serbia)

D. Radivojević

University of Belgrade

IĐ

Ilija Đjekić

University of Belgrade

ĐB

Đorđe Boškov

University of Belgrade

Mirjana Stojanović-Tasić

University of Prishtina

M. Relić

University of Prishtina

Bianca Wolf

TU Bergakademie Freiberg

Cooperative Institutions

University of Belgrade

Maize Research Institute Zemun Polje

Institute for Multidisciplinary Research

Zemun Hospital

Institute of Agricultural Economics Belgrade

Institut za savremenu istoriju

TU Bergakademie Freiberg

Institute of General and Physical Chemistry

University of Prishtina

Pfizer (United Kingdom)

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Lichen planus disseminatus partim vesiculosus after COVID-19 vaccine

Praxis medica (2021)

Dragica Milosavljević M. Relić Mirjana Stojanović-Tasić

<jats:p>Introduction: Lichen planus is an autoimmune inflammatory disease that can be associated with infections, drugs and vaccines. As concerning the potential triggering effect of vaccine, there is evidence a few cases of new-onset lichen planus that appeared after COVID vaccine, particularly the Pfizer/BioNTech vaccine. Case report: This report is a case of a newonset lichen planus triggered by the Pfizer/BioNTech vaccine administration in a healthy young female. Dermatological examination revealed polygonal, itchy, erythematous papules on trunk, upper and lower limbs, that coalesced into brownish plaques in the ankles, flexural wrist and knee. No mucosal involvement was noted. In view of the clinical picture, the timing of the skin eruption with respect to the vaccine and the histopathologic findings, a vaccine-induced lichen planus triggered by the COVID-19 vaccine has been diagnosed. Conclusion: Lichen planus or lichenoid-like eruption as a cutaneous manifestation following COVID-19 vaccines are rare, and the pathogenesis for its development is still unclear. Clinical trials showed that the leading vaccines upregulate Tcell response (Th1) and incrementing inflammatory cytokines involved in the pathogenesis of autoimmune diseases, such as lichen planus. Although we still do not completely understand its pathogenesis, dermatologists should be aware of the possibility and keep an eye out for worsening or debut of this disease after the COVID-19 vaccine. Vaccinated patients should be monitored for skin manifestations, and dermatological evaluation should be offered, when needed.</jats:p>

Pathogenesis

10.5937/pramed2202059m

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Productivity and fruit quality of ‘Clery’ strawberry affected by planting density in a soilless growing system

Acta Horticulturae (2021)

J. Milivojević D. Radivojević Đorđe Boškov Dragica Milosavljević Vuk Maksimović

Hydroponics

10.17660/actahortic.2021.1309.40

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Citations (1)

ACTION OF CALCIUM INHIBITORS ON CONTRACTILITY OF THE ISOLATED TERMINAL ILEUM OF THE GUINEA-PIG

Elsevier eBooks (1978)

Tomislav Kažić Dragica Milosavljević

Contractility

Terminal ileum

10.1016/b978-0-08-023768-8.50087-6

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A comparison of major taste- and health-related compounds among newly released Italian strawberry cultivars

Acta Horticulturae (2021)

Dragica Milosavljević Vuk Maksimović J. Milivojević Jelena Dragišić Maksimović

10.17660/actahortic.2021.1309.120

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Citations (4)

Rich in Phenolics—Strong Antioxidant Fruit? Comparative Study of 25 Strawberry Cultivars

Plants (2022)

Dragica Milosavljević Vuk Maksimović J. Milivojević Đura Nakarada Miloš Mojović

Phenolic compounds of 25 newly introduced strawberry cultivars were profiled using spectrophotometry, electron paramagnetic resonance (EPR) spectroscopy, and high-performance liquid chromatography-mass spectrometry. Total phenolic and anthocyanin content (TPC and TACY, respectively), as well as vitamin C, and concentrations of individual phenolic compounds in fruits were evaluated to identify the most promising cultivars according to their phenolic profile. The highest values of TPC, TACY, and vitamin C were recorded in ‘Premy’ (1.53 mg eq GA g−1 FW), ‘Sandra’ (30.60 mg eq Pg-3-g 100 g−1 FW), and ‘Laetitia’ (56.32 mg 100 g−1 FW), respectively. The DPPH and •OH radicals scavenging activity of fruit methanolic extracts was estimated using EPR spectroscopy. All cultivars are almost uniformly effective in the scavenging of •OH radical, while ‘Tea’, ‘Premy’, and ‘Joly’ were marked as highly potent cultivars (over 70%) in terms of DPPH-antiradical activity. Specific peroxidase activities were the highest in ‘Garda’, ‘Federica’, and ‘Rumba’ (0.11, 0.08, and 0.06 U mg−1 prot, respectively). ‘Laetitia’, ‘Joly’, ‘Arianna’, ‘Tea’, and ‘Mila’ cultivars were distinguished from others as the richest concerning almost all flavonoids and phenolic acids, including some other parameters of bioactivity. These cultivars could be recommended to consumers as functional fruit foods.

10.3390/plants11243566

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Phenolic Profiling of 12 Strawberry Cultivars Using Different Spectroscopic Methods

Journal of Agricultural and Food Chemistry (2020)

Dragica Milosavljević Dragosav Mutavdžić Ksenija Radotić J. Milivojević Vuk Maksimović

Phenolic compounds of 12 strawberry cultivars were profiled using spectrophotometry, spectrofluorometry, and high-performance liquid chromatography–mass spectrometry, coupled with multivariate regression analysis. Total phenolic content, total anthocyanin content, and total antioxidant capacity (TPC, TACY, and TAC, respectively) and concentrations of individual phenolics were evaluated, and the multivariate statistic was employed to identify the most promising cultivars based on their phenolic content. According to the principal component analysis, TAC was strongly correlated with the TPC (0.81), pointing out its importance in overall antioxidant activity. 'Joly', 'Laetitia', and 'Asia' cultivars were distinguished from others as the richest in concerning identified anthocyanins, almost all flavonoids and phenolic acids. Multivariate curve resolution with alternating least squares indicated the presence of two main types of fluorophores assigned to anthocyanins and phenolics, in which emission spectral ratios also showed the highest values in the referred cultivars. These cultivars could be recommended to consumers in terms of the health functionality of fruit.

Chemometrics

10.1021/acs.jafc.9b07331

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Citations (23)

Influence of adenosine, cAMP and db-cAMP on responses of the isolated terminal guinea-pig ileum to electrical stimulation.

PubMed (1976)

Tomislav Kažić Dragica Milosavljević

Adenosine, cAMP and db-cAMP were found to inhibit nerve-mediated contractions of the terminal ileum elicited by electrical stimulation (ES). Responses to ES at 30 Hz, which are believed to be of adrenergic origin, were considerably more affected than the responses to ES at 3 Hz, which may be of purinergic orign. The following order of relative inhibitory potencies was established: adenosine greater than cAMP greater than db-cAMP. Adenosine, cAMP and db-cAMP did not affect the contractile responses of the preparation to histamine, potassium and noradrenaline. Therefore, the observed inhibition of nerve-mediated contractions was thought to be due to an action on presynaptic sites, i.e. on the neural network within the intestine. This action was antagonized by an increase in external calcium and by aminophylline, which is known to increase intracellular calcium. The present experiments suggests that the inhibitory action of adenosine, cAMP and db-cAMP results from a reduction of calcium fluxes across the neural membrane and to a subsequent reduction in the release of neurotransmitter(s). The inhibitory effect of cAMP appeared to be nonspecific and was presumably related to adenosine in its molecule.

Aminophylline

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Comparison of field performance and fruit quality among newly released Italian June-bearing strawberry cultivars

Journal of Agricultural Sciences Belgrade (2023)

J. Milivojević D. Radivojević Dragica Milosavljević Vuk Maksimović Jelena Dragišić Maksimović

The aim of this study was to compare newly released June-bearing strawberry cultivars (?Quicky?, ?Sandra?, ?Lofty?, ?Nadja? and ?Aprica?) in terms of their phenology, vegetative growth, productivity and fruit quality to identify their potential for wider cultivation. A field study was conducted in a strawberry plantation established in July 2020 in double rows on beds covered with black polyethylene foil (Sid, Serbia). The cultivars were evaluated in 2021-2022 for their flowering and ripening time, productivity, plant growth, biometrical and nutritional fruit traits (soluble solids content - SSC, total acids - TAs, vitamin C, total anthocyanins - TACY, total phenolics - TPC and total antioxidant capacity - TAC). The cultivar ?Quicky? started to ripen earliest, while ?Aprica? was the latest in both experimental years. The number of branch crowns per plant was significantly higher in ?Sandra? and ?Lofty?, whereby ?Sandra? had also the highest number of leaves per rosette (41.5) in comparison with the other tested cultivars. The cultivar ?Aprica? was superior in terms of productivity (1061 g/plant and 4.67 kg/m2), fruit weight (29.9 g) and fruit shape index (1.15). Contrary to this, ?Nadja? was the least productive cultivar (608 g/plant and 2.68 kg/m2). The cultivars ?Lofty? and ?Sandra? showed the highest SSC values and were also characterized by a considerably high level of TPC (1.29 mg GAE eq g-1 FW) and TACY (24.4 mg pg-3-g eq 100 g-1 FW), respectively. Variability among the tested cultivars could serve as an important criterion for the selection of new high-performing cultivars for a given growing region.

10.2298/jas2302201m

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INTERACTION BETWEEN ADENOSINE TRIPHOSPHATE AND NORADRENALINE IN THE ISOLATED VAS DEFERENS OF THE GUINEA‐PIG

British Journal of Pharmacology (1980)

Tomislav Kažić Dragica Milosavljević

An interaction between adenosine triphosphate (ATP) and noradrenaline (NA) was investigated in the isolated vas deferens of the guinea‐pig. ATP (1.7 to 50 μ m ) enhanced contractions due to transmural electrical stimulation (ES; parameters: 30 Hz, 0.2 to 0.3 ms, 10 to 30 V; 1 s train duration). Responses to exogenous NA (12 μ m ) were also potentiated by ATP while contractions to acetylcholine (6 μ m ) were inhibited. NA (1.2 μ m ) potentiated ATP‐induced contractions and prevented the development of tachyphylaxis to ATP (510 μ m ). Phentolamine (12.5 μ m ) prevented the potentiation by NA of ATP‐induced contractions; these contractions were insensitive to phentolamine (up to 25 μ m ). Removal of potassium chloride from the Tyrode solution for 10 min abolished the potentiating actions of both ATP and NA. The present results suggest that the effect of ATP may be functionally closely related to that of NA at α‐adrenoceptors in the vas deferens of the guinea‐pig.

Vas deferens

Phentolamine

Adenosine triphosphate

Tachyphylaxis

10.1111/j.1476-5381.1980.tb10913.x

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Citations (35)

Influence of pyridylisatogen tosylate on contractions produced by ATP and by purinergic stimulation in the terminal ileum of the guinea-pig

Journal of Pharmacy and Pharmacology (1977)

Tomislav Kažić Dragica Milosavljević

Abstract 2-2′Pyridylisatogen tosylate (PIT), which antagonizes the inhibitory action of ATP in the taenia caeci, did not antagonize the excitatory effects of exogenous ATP and of purinergic stimulation of the terminal guinea-pig ileum. PIT (0·5–2·5 μm) potentiated the ATP-induced contractions and also the contractions produced by potassium chloride, though the potentiation could not be related to the dose in every experiment. The responses to noradrenaline, adrenaline and histamine were slightly inhibited. PIT also potentiated the contractions produced by electrical stimulation of intramural purinergic nerves when either an alternate or uniform stimulation pattern was used. The present results in which the preparation is contracted by ATP are opposite to those obtained with PIT on the taenia caeci, which is relaxed by ATP. This raises a question of duality or plurality of receptors for ATP.

Taenia coli

10.1111/j.2042-7158.1977.tb11392.x

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Citations (21)