Liquid waste is a source of water pollution whichis a problem for the surrounding environment. Liquid waste contains high levels of organic pollutants as well as suspended and dissolved solids which under go physical, chemical and biological changes. Liquid waste known to contain high levels of organic material, namely industrial and domestic waste. The purpose of this study was to determine the levels of BOD, COD, TSS and ammonia in samples of domestic liquid waste and the rubber industry in Palembang. The type of research carried out in this research is descriptive qualitative. Data were analyzed and presented in tabular form, from the data it was found that the results of BOD in domestic waste inlet 107.25 mg/L, outlet 33.3 mg/L did not meet quality standard and industrial waste inlet 113.5 mg/L outlet 33.3 mg/L meet the quality standard, COD results in domestic waste inlet 62.6 mg/L, outlet 91.7mg/L and in industrial waste inlet 78.2 mg/L, outlet 73.1 mg/L meet quality standards, TSS in domestic waste inlet 116 mg/L, outlet 27.7 mg/L and industrial waste inlet 88 mg/L, outlet 22.5 mg/L meet the quality standard. And the results of domestic waste ammonia inlet 6.5895 mg/L, outlet 4.5365mg/L and industrial waste inlet 13.85 mg/L, outlet 1.5165 mg/L meet the quality standards of waste water according to the regulation of the Minister of Environment and Forestry I No P. 68 /Menihk/Setjen/Kum. 1/ 8/2016.