Jorge Alcocer‐Varela

Universidad Chapultepec

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D Alarcón-Segovia

Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán

Diana Gómez‐Martín

Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán

Javier Merayo‐Chalico

Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán

José C. Crispín

Tecnológico de Monterrey

Ana Barrera‐Vargas

Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán

Luis Llorente

Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán

Gilberto Vargas‐Alarcón

Instituto Nacional de Cardiología

Carlos Abud‐Mendoza

Autonomous University of San Luis Potosí

Yvonne Richaud‐Patín

Biomedical Research Networking Center in Bioengineering, Biomaterials and Nanomedicine

Mariana Díaz‐Zamudio

University Radiology

Cooperative Institutions

Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán

214

Universidad Nacional Autónoma de México

Center for Rheumatology

Mexican Social Security Institute

Harvard University

National Institutes of Health

Inserm

Secretaria de Salud

Instituto Nacional de Cardiología

Tel Aviv University

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Interferon regulatory factors: Beyond the antiviral response and their link to the development of autoimmune pathology

Autoimmunity Reviews (2011)

Karina Santana-de Anda Diana Gómez‐Martín Mariana Díaz‐Zamudio Jorge Alcocer‐Varela

Interferon type I

10.1016/j.autrev.2011.08.006

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Citations (46)

Adult-Onset Still Disease as the Cause of Fever of Unknown Origin

Medicine (2005)

José C. Crispín Déborah Martı́nez-Baños Jorge Alcocer‐Varela

We conducted the current study to evaluate the cases of fever of unknown origin (FUO) admitted in our institution during the 10 years between 1991 and 2001 and to compare the patients diagnosed as having adult-onset Still disease (AOSD) with the patients with FUO due to other diagnoses. We performed a case-control study and analyzed 26 patients with AOSD and 135 patients with FUO due to other diseases. Controls were classified into 1 of 4 groups: 1. Infectious diseases; 2. Malignant conditions; 3. Autoimmune diseases; 4. No diagnosis. Differences between groups were evaluated by analysis of variance (ANOVA). Odds ratios (OR) were calculated by multiple logistic regression analyses. Patients with AOSD were younger than controls. Arthritis (OR, 8.6; 95% confidence interval [CI], 1.5-49.1; p = 0.014), pharyngitis (OR, 6.9; 95% CI, 1.5-30.2; p = 0.010), splenomegaly (OR, 5.4; 95% CI, 1.1-26.7; p = 0.039), and neutrophilic leukocytosis (OR, 18.1; 95% CI, 3.5-93.6; p = 0.001) were significantly more common in patients with AOSD than in the control groups. A clinical scale that identifies patients with AOSD was designed. It proved to be highly specific (≈98%), with predictive values greater than 90%. AOSD is a defined clinical entity. In most cases, it is clinically distinguishable from other causes of FUO. We propose a clinical scale as a tool to identify patients whose disease can be diagnosed based on clinical grounds without the need of long, costly diagnostic procedures. Abbreviations: AOSD = adult-onset Still disease, FUO = fever of unknown origin.

Leukocytosis

10.1097/01.md.0000188009.47085.76

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Citations (90)

[The researchers of the National Institutes of Health. Their vicissitudes in the National System of Health].

PubMed (2004)

Jorge Alcocer‐Varela

Medical researchers that work at the National Institutes of Health have a preponderant role in the scientific production of Mexico. This article focuses their behavior during the last 12 years, within the National System of Investigators (SNI). According to the citation and publication indices, the medical researchers are of greater productivity and quality. The number of investigators of the Institutes that have obtained their entrance to the SNI has grown in 129.8%, during the period of study and has been constant in each one of the Institutes of Health, with the exception of the INPer, that besides to have smaller number of researchers within the SNI, shows a tendency to low. The investigators level 1 have stayed between 10 to 12 per year in most of the Institutes, with exception of Nutrition, Cardiology and Public Health that have managed to maintain effective to more than 20 investigators of this level during the last 5 years; in the case of Nutrition over 30. These three Institutes also have maintained the greater number of investigators level 2 and 3; it emphasizes Nutrition that is counted with the average of publications by researcher in the institutes is of 4.9 +/- 3 papers. The researchers of Nutrition, Pediatría, the INPer and Neurology contribute with more than 4 publications by each year. Nevertheless, when we only included the publications of groups III-V, only the researchers of Nutrition publish annually 6 to 7 high quality research paper. All the professionals of the Institutes that have an appointment of Investigator in Medical Sciences do not belong to the SNI. In the case of the Institute of Medical Sciences and Nutrition, of 131 workers with this appointment (Julio 2003), only 47 (35.9%) belong to the NSI. When analyzing the participation of the professionals that do not belong to the SNI in the mentioned published papers from 1999 to 2002 it was found that of 484 publications of group III, in 108 (22%) nonmembers of the SNI and without appointment of investigator participated in these publications; of 85 of group IV, in 16 (19%) and of 52 of group V, in 12 (23%). Of the analysis of this information, strategies directed to particular groups can be undertaken, to mainly increase the scientific productivity in the National Institutes of Health and, to improve their quality and its scientific impact.

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Citations (1)

High levels of TH2 cytokine gene expression in systemic lupus erythematosus.

PubMed (1995)

Yvonne Richaud‐Patín Jorge Alcocer‐Varela Luis Llorente

Systemic lupus erythematosus (SLE) is an autoimmune disease with a clear imbalance in the network made up of different cytokines. However this statement has been derived from studies which have focused on the analysis of some specific cytokines and few have simultaneously analyzed those cytokines that could be involved in the pathogenesis of SLE. Therefore, we decided to analyze interleukin IL-1b, IL-2, IL-4, IL-6, IL-10, tumor necrosis factor-a (TNF-a) and gamma interferon (IFN-g) gene expression in peripheral blood mononuclear cells from 17 women with SLE and 10 normal females by a coupled reverse transcriptase-polymerase chain reaction technique. High gene expression of IL-4, IL-6, IL-10 and TNF-a was found in SLE patients as compared to normal subjects. The expression of IL-1b, IL-2 and IFN-g genes was low or undetectable. The resulting high level of cytokines with strong effect on proliferation and differentiation of B lymphocytes in SLE could be responsible for the characteristic B cell hyperactivity and autoantibody production seen in SLE.

Pathogenesis

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Citations (106)

[Hematologic changes in systemic lupus erythematosus].

PubMed (1980)

Jorge Alcocer‐Varela Miranda-Limón Jm Vargas de Azaola Me Carlos Lavalle-Montalvo Antonio Fraga-Mouret

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Probable depiction of juvenile arthritis by sandro botticelli

Arthritis & Rheumatism (1983)

D Alarcón-Segovia A Laffón Jorge Alcocer‐Varela

Abstract There is a question whether rheumatoid arthritis is a disease of recent or ancient onset since it was only first described in 1800. In support of its earlier appearance are depictions of rheumatoid hands in Flemish paintings of the fifteenth through eighteenth centuries. The first description of juvenile arthritis is attributed to Cornil in 1864, making the question of its antiquity also pertinent. We show here that the “Portrait of a Youth,” painted in 1483 by the Florentine artist Sandro Botticelli, has features of rheumatoid arthritis in the hand of the subject, who would be young enough to be considered as having juvenile arthritis. A review of all of Botticelli's paintings revealed that these changes could not be attributed to stylistic traits. Neither could they be attributed to lack of technique, for he has been considered a superb artist. If the “Portrait of a Youth” does indeed represent juvenile arthritis, it would mean that this disease is older than its initial description would indicate.

Portrait

Flemish

Juvenile rheumatoid arthritis

Depiction

Fifteenth

10.1002/art.1780261014

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Citations (28)

Longitudinal study on the production of and cellular response to interleukin-2 in patients with systemic lupus erythematocus

Rheumatology International (1995)

Jorge Alcocer‐Varela Donato Alarc�n-Segovia

Systemic lupus

10.1007/bf00262709

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Citations (19)

Amebic monocyte locomotion inhibitory factor peptide ameliorates inflammation in CIA mouse model by downregulation of cell adhesion, inflammation/chemotaxis, and matrix metalloproteinases genes

Inflammation Research (2010)

Susana Godina-González Janette Furuzawa‐Carballeda Dolores Utrera‐Barillas Jorge Alcocer‐Varela Luis M. Terán

Monocyte

10.1007/s00011-010-0224-2

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Citations (13)

Differential serum cytokine profile in patients with systemic lupus erythematosus and posterior reversible encephalopathy syndrome

Clinical & Experimental Immunology (2017)

Javier Merayo‐Chalico Ana Barrera‐Vargas Guillermo Juárez‐Vega Jorge Alcocer‐Varela Antonio Araúz

Systemic lupus erythematosus (SLE) patients are susceptible to the development of posterior reversible encephalopathy syndrome (PRES). The main theory concerning the physiopathology of PRES suggests that there is brain-blood barrier damage, which is associated with endothelial dysfunction, and characterized by vasogenic oedema. However, current evidence regarding its physiopathogenic mechanisms is quite scant. The aim of this study was to analyse the expression of different serum cytokines, as well as vascular endothelial growth factor (VEGF) and soluble CD40 ligand (sCD40L), in patients with PRES/systemic lupus erythematosus (SLE) and to compare them with levels in SLE patients without PRES and in healthy controls. We performed a transversal study in a tertiary care centre in México City. We included 32 subjects (healthy controls, n = 6; remission SLE, n = 6; active SLE, n = 6 and PRES/SLE patients, n = 14). PRES was defined as reversible neurological manifestations (seizures, visual abnormalities, acute confusional state), associated with compatible changes by magnetic resonance imaging (MRI). Serum samples were obtained during the first 36 h after the PRES episode and were analysed by cytometric bead array, Luminex multiplex assay or enzyme-linked immunosorbent assay (ELISA). Interleukin (IL)-6 and IL-10 levels were significantly higher in PRES/SLE patients (P = 0·013 and 0·025, respectively) when compared to the other groups. Furthermore, IL-6 and IL-10 levels displayed a positive correlation (r = 0·686, P = 0·007). There were no differences among groups regarding other cytokines, sCD40L or VEGF levels. A differential serum cytokine profile was found in PRES/SLE patients, with increased IL-6 and IL-10 levels. Our findings, which are similar to those described in other neurological manifestations of SLE, support the fact that PRES should be considered among the SLE-associated neuropsychiatric syndromes.

Pathophysiology

Pathogenesis

Hypertensive encephalopathy

10.1111/cei.13095

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Citations (17)

Immunogenetics of mixed connective tissue disease in a Mexican Mestizo population.

PubMed (1999)

Ana Luisa Weckmann J Granados M H Cardiel Felipe Andrade Gilberto Vargas‐Alarcón

The aim of this study was to determine the HLA antigens in Mexican Mestizo patients with mixed connective tissue disease (MCTD).We studied 30 patients with MCTD and 99 healthy controls. HLA-A, -B, and -DQ antigens were typed by microlymphocytotoxicity assays. DRB1, DQA1 and DQB1 alleles were oligotyped.HLA-A2 and HLA-B35 were the most frequent MHC class I alleles in MCTD patients, although they were not statistically more frequent than in the controls. According to serological tests, the most frequent DQ allele in the patients was DQ1, which was statistically increased when compared with controls (p = 0.0051). By oligotyping, the DR1 allele and the DQB1*0501 specificities were significantly increased in the patients vs. controls (p = 0.032 and 0.027, respectively).The elevated levels of DQ1 found in Mexican MCTD patients, although weak, may indicate a particular genetic susceptibility, since there are previous reports of associations of other alleles (such as DR4) with MCTD in other populations. The increase in DQB1*0501 may account for the increase in DQ1. DQB1*0501 has also been reported in black patients with anti-RNP autoantibodies, compared with black patients without anti-RNP or anti-Sm.

Immunogenetics

Extractable nuclear antigens

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Citations (13)