Kwong‐Sak Leung

Chinese University of Hong Kong

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Man Leung Wong

Lingnan University

Man‐Hon Wong

Chinese University of Hong Kong

Yee Leung

Chinese University of Hong Kong

Lixin Cheng

Southern University of Science and Technology

Kin Hong Lee

Chinese University of Hong Kong

Hongjian Li

China University of Labor Relations

Sin Man Cheang

Hong Kong Institute of Vocational Education

Kin-Hong Lee

Chinese University of Hong Kong

Jack C. Y. Cheng

Takeda (Japan)

Man–Leung Wong

Lingnan University

Cooperative Institutions

Chinese University of Hong Kong

385

University of Cyprus

197

Applied Multilayers (United Kingdom)

189

University of Hong Kong

Prince of Wales Hospital

Chinese Academy of Sciences

Jinan University

National and Kapodistrian University of Athens

University of Patras

Zhengzhou University

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Use of the Medial Plantar Flap in Soft Tissue Replacement Around the Heel Region

Foot & Ankle (1988)

Professor P. C. Leung L.K. Hung Kwong‐Sak Leung

Large ulcers around the heel region are common but difficult problems because the usual methods of resurfacing are unsatisfactory. Twelve cases of such ulcers were covered with medial plantar vascular pedicled flaps and the results had been excellent. The operative procedures were simple and the quality of skin supplied was perfect. Different sizes of medial plantar flaps may be used, based on the available branches of the posterior tibial vessels.

10.1177/107110078800800608

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Citations (8)

A robust and generalizable immune-relatedsignature for sepsis diagnostics

arXiv (Cornell University) (2020)

Yueran Yang Yu Zhang Shuai Li Xubin Zheng Man‐Hon Wong

High-throughput sequencing can detect tens of thousands of genes in parallel, providing opportunities for improving the diagnostic accuracy of multiple diseases including sepsis, which is an aggressive inflammatory response to infection that can cause organ failure and death. Early screening of sepsis is essential in clinic, but no effective diagnostic biomarkers are available yet. Here, we present a novel method, Recurrent Logistic Regression, to identify diagnostic biomarkers for sepsis from the blood transcriptome data. A panel including five immune-related genes, LRRN3, IL2RB, FCER1A, TLR5, and S100A12, are determined as diagnostic biomarkers (LIFTS) for sepsis. LIFTS discriminates patients with sepsis from normal controls in high accuracy (AUROC = 0.9959 on average; IC = [0.9722-1.0]) on nine validation cohorts across three independent platforms, which outperforms existing markers. Our analysis determined an accurate prediction model and reproducible transcriptome biomarkers that can lay a foundation for clinical diagnostic tests and biological mechanistic studies.

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The impact of particulate matter air pollution (PM2.5) on atherosclerosis in modernizing China: a report from the CATHAY study

International Journal of Epidemiology (2020)

Kam S. Woo Ping Chook Yan Hu Xiang Qian Lao Changqing Lin

Air pollution has been associated with an increase in cardiovascular diseases incidence. To evaluate whether air pollution can accelerate atherogenic processes, we assessed the effects of air pollution on important surrogate markers of atherosclerosis [brachial flow-mediated dilation (FMD) and carotid intima-media thickness (IMT)].A total of 1656 Han Chinese (mean age 46.0 + 11.2 years; male 47%) in Hong Kong, Macau, Pun Yu, Yu County and the 3-Gorges Territories (Yangtze River) were studied between 1996 and 2007 [Chinese Atherosclerosis in the Aged and Young Project (the CATHAY Study)]. Cardiovascular risk profiles were evaluated. Particulate matter with an aerodynamic diameter <2.5 µm (PM2.5) parameters were computed from satellite sensors. Brachial FMD and carotid IMT were measured by ultrasound.Health parameters [age, gender, body mass index, waist : hip ratio (WHR) and glucose)] were similar in lowest and highest PM2.5 exposure tertiles, systolic and diastolic blood pressures and triglycerides were higher (P < 0.001) and low-density cholesterol (LDL-C) was lower in the top PM2.5 tertile (P < 0.001). Brachial FMD [7.84 ± 1.77, 95% confidence interval (CI) 7.59-8.10%, vs 8.50 ± 2.52, 95% CI 8.23-8.77%, P < 0.0001) was significantly lower and carotid IMT (0.68 ± 0.13 mm, 95% CI 0.67-0.69 mm vs 0.63 mm ± 0.15 mm 95% CI 0.62-0.64 mm; P < 0.0001) was significantly thicker in the top PM2.5 tertile compared with the lowest tertile. On multiple regression, FMD was inversely related to PM2.5 (beta = 0.134, P = 0.015) independent of gender, age and blood pressure (model R2 = 0.156, F-value = 7.6, P < 0.0001). Carotid IMT was significantly correlated with PM2.5 exposure (beta = 0.381, P < 0.0001) independent of age, location, gender, WHR, blood pressure and LDL-C (model R2 = 0.408, F-value = 51.4, P-value <0.0001).Air pollution is strongly associated with markers of early atherosclerosis, suggesting a potential target for preventive intervention.

Intima-media thickness

Brachial artery

10.1093/ije/dyaa235

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Citations (32)

Generic Routing Encapsulation (GRE) Key Extension for Mobile IPv4

P. Yegani Kwong‐Sak Leung Avi Lior Kafil Chowdhury Jay Navali

The GRE specification contains a Key field, which MAY contain a value that is used to identify a particular GRE data stream. This specification defines a new Mobile IP extension that is used to exchange the value to be used in the GRE Key field. This extension further allows the Mobility Agents to setup the necessary protocol interfaces prior to receiving the mobile's traffic. The new extension option allows a foreign agent to request GRE tunneling without disturbing the Home Agent behavior specified for Mobile Ipv4. GRE tunneling provides an advantage that allows operator's private home networks to be overlaid and allows the HA to provide overlapping home addresses to different subscribers. When the tuple < Care of Address, Home Address and Home Agent Address > is the same across multiple subscriber sessions, GRE tunneling will provide a means for the FA and HA to identify data streams for the individual sessions based on the GRE key. In the absence of this key identifier, the data streams cannot be distinguished from each other, a significant drawback when using IP-in-IP tunneling.

Encapsulation

IPv4

10.17487/rfc6245

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Stochastic algorithms for optimal placements of flexible objects

Shing Kwong Cheung Chak Kuen Wong Kwong‐Sak Leung

This thesis deals with the computation of equilibrium states for the placement of flexible (elastic or deformable) objects within rigid boundaries. Our goal is to develop algorithms optimizing placements of flexible objects. The potential applications of our approach are in the design of new amorphous polymeric and related materials as well as in the design of package cushioning systems. Firstly, we derive an approximate deformation/force formula for the flexible objects and propose simulated annealing algorithms (SAAs) to solve the problem. The annealing procedure makes use of the special structure of the underlying configuration space and relationships between deformations of flexible objects and resulting forces. This allows us to obtain tight bounds for the annealing parameters which result in n3/2 - ln 5/2 n and n - ln2 n time bounds (where n is the number of flexible objects), respectively, for the computation of equilibrium states by two different cooling schedules. The SAAs are then parallelized by two models. Secondly, an alternative hybrid two-phase algorithm based on evolutionary programming (TPEP) is proposed. The first phase is based on the evolutionary programming technique. Its main function is to produce an outline placement pattern of the final solution. The second phase further improves the outline pattern to reach the final equilibrium states by local optimization with adaptive grid size based on the convergence of the sum of forces. Thirdly, adaptive simulated annealing algorithms (ASAAs), which are based on the previous proposed SAAs, are further proposed. It is distinguished from the proposed SAAs that the pre-defined cooling schedules and grid size generation procedure are replaced by an adaptive control method. It effectively eliminates the user-specified control parameters that we have to define in the previous two approaches. From the experimental results, both the TPEP and ASAAs out-performed the previous simulated annealing approach both in terms of run-time and the final sum of forces. The TPEP has the advantage that it requires less hidden cost in designing cooling schedules while the ASAAs, with specifically tailored adaptive cooling schedules and adaptive grid size control, outperform the other two approaches with proven time complexity upper bounded by O(n · ln2 n). Finally, we have further extended our problem model and apply the approach to two other application problems, namely stochastic simulation of two-dimensional composite packings, and computing elastic moduli of two-dimensional random networks of rigid and nonrigid bonds. It shows that our approach is, indeed, applicable to many other similar applications. (Abstract shortened by UMI.)

Adaptive simulated annealing

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Evolve Schema Directly Using Instruction Matrix Based Genetic Programming

Lecture notes in computer science (2005)

Gang Li Kin Hong Lee Kwong‐Sak Leung

Schema (genetic algorithms)

Gene expression programming

Binary expression tree

10.1007/978-3-540-31989-4_24

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A modified edge recombination operator for the Travelling Salesman Problem

Lecture notes in computer science (1994)

Anthony Yiu-Cheung Tang Kwong‐Sak Leung

Operator (biology)

Benchmark (surveying)

10.1007/3-540-58484-6_262

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Citations (22)

Mobile Node Identifier Option for Mobile IPv6 (MIPv6)

A. Patel Kwong‐Sak Leung Mohamed Khalil Haseeb Akhtar Kuntal Chowdhury

Mobile IPv6 (MIPv6) defines a new Mobility header that is used by mobile nodes, correspondent nodes, and home agents in all messaging related to the creation and management of bindings. Mobile IPv6 nodes need the capability to identify themselves using an identity other than the default home IP address. Some examples of identifiers include Network Access Identifier (NAI), Fully Qualified Domain Name (FQDN), International Mobile Station Identifier (IMSI), and Mobile Subscriber Number (MSISDN). This document defines a new mobility option that can be used by Mobile IPv6 entities to identify themselves in messages containing a mobility header. [STANDARDS-TRACK]

10.17487/rfc4283

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The Use of Random Forest to Predict Binding Affinity in Docking

Lecture notes in computer science (2015)

Hongjian Li Kwong‐Sak Leung Man-Hon Wong Pedro J. Ballester

Docking (animal)

10.1007/978-3-319-16480-9_24

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Bulk Binding Update Support for Proxy Mobile IPv6

Kwong‐Sak Leung Suresh Krishnan Domagoj Premec

For extending the lifetime of a mobility session, the Proxy Mobile IPv6 specification requires the mobile access gateway to send a Proxy Binding Update message to the local mobility anchor on a per-session basis.In the absence of signaling semantics for performing operations with group-specific scope, this results in a significant amount of signaling traffic on a periodic basis between a given mobile access gateway and a local mobility anchor.This document defines optimizations to the binding update and revocation operations in Proxy Mobile IPv6 for performing operations with group-specific scope with the use of a group identifier.

Proxy Mobile IPv6

Proxy (statistics)

10.17487/rfc6602

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Citations (7)