Sara Ferreira dos Santos Costa

Universidade Federal de Minas Gerais

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Felipe Paiva Fonseca

Universidade Federal de Minas Gerais

Ricardo Santiago Gomez

Universidade Federal de Minas Gerais

Pablo Agustín Vargas

Universidade Estadual de Campinas (UNICAMP)

Manoela Domingues Martins

Universidade Federal do Rio Grande do Sul

Carolina Cavaliéri Gomes

Universidade Federal de Minas Gerais

Hélder Antônio Rebelo Pontes

Universidade Estadual de Campinas (UNICAMP)

Oslei Paes de Almeida

Universidade Estadual de Campinas (UNICAMP)

Jean Nunes dos Santos

Universidade Federal da Bahia

Adriana Franco Paes Leme

Laboratório Nacional de Ciência e Tecnologia do Bioetanol

Lucas Guimarães Abreu

Universidade Federal de Minas Gerais

Cooperative Institutions

Universidade Federal de Minas Gerais

Universidade Estadual de Campinas (UNICAMP)

Fundação Faculdade de Odontologia

Universidade de São Paulo

Universidade Federal do Rio de Janeiro

Universidade Federal de Sergipe

Universidade Federal do Rio Grande do Norte

RELX Group (United States)

Methodist University of Piracicaba

Universidade Federal do Pará

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Epstein-Barr Virus-Positive Diffuse Large B-Cell Lymphoma, Not Otherwise Specified, in the Oral Cavity

Journal of Craniofacial Surgery (2019)

Sara Ferreira dos Santos Costa André Myller Barbosa Silva Gleyson Kleber do Amaral‐Silva Hélder Antônio Rebelo Pontes Flávia Sirotheau Corrêa Pontes

Abstract Lymphomas of the oral cavity are rare and the most frequent type is diffuse large B-cell lymphoma (DLBCL). Epstein–Barr virus (EBV) is known to be associated with the development of different lymphomas. In 2008, the World Health Organization provisionally included the EBV-positive DLBCL of the elderly in the classification of hematopoietic and lymphoid tumors as a lymphoma occurring in older individuals without any known immunodeficiency. However, it has since been recognized that this entity may occur in younger individuals and present similar clinical parameters in both age groups. As a result, the 2017 revision has declined the term elderly and modified it to EBV-positive DLBCL, not otherwise specified (NOS). In this report, we describe a rare case of EBV-positive DLBCL, NOS, presenting as a painless swelling in the oral cavity. This entity shows a more aggressive clinical course than EBV-negative DLBCL, and other lymphoproliferative disorders should be considered in the differential diagnosis.

Not Otherwise Specified

Lymphoproliferative Disorders

10.1097/scs.0000000000005302

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Citations (1)

MASS SPECTROMETRY-BASED PROTEOME PROFILE DIFFERENTIATES ADENOID CYSTIC CARCINOMA FROM POLYMORPHOUS ADENOCARCINOMA

Oral Surgery Oral Medicine Oral Pathology and Oral Radiology (2019)

Felipe Paiva Fonseca Sara Ferreira dos Santos Costa CAROLINA SOARES CARNEIRO MACEDO Adriana Franco Paes Leme Hélder Antônio Rebelo Pontes

Adenoid Cystic Carcinoma

Proteome

Laser capture microdissection

UniProt

10.1016/j.oooo.2019.06.641

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FREQUENCY AND PROGNOSTIC IMPORTANCE OF TRANSLOCATION (6;9) (MYB-NFIB GENES) IN HEAD AND NECK ADENOID CYSTIC CARCINOMA: A SYSTEMATIC REVIEW

Oral Surgery Oral Medicine Oral Pathology and Oral Radiology (2019)

YASMIN DIAS DE ALMEIDA PINTO Sara Ferreira dos Santos Costa Bruno Augusto Benevenuto de Andrade Albina Altemani Pablo Agustín Vargas

Adenoid Cystic Carcinoma

MYB

Adenoid

10.1016/j.oooo.2019.06.634

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Molecular basis of oral squamous cell carcinoma in young patients: Is it any different from older patients?

Journal of Oral Pathology and Medicine (2017)

Sara Ferreira dos Santos Costa Peter A. Brennan Ricardo Santiago Gomez Eduardo Rodrigues Fregnani Alan Roger Santos‐Silva

Oral squamous cell carcinoma ( OSCC ) is the commonest subtype of oral cancer, mainly affecting older patients. It used to be a rare disease among individuals younger than 40 years, but recently increased incidences in this age group are being reported worldwide. The pathogenesis of OSCC affecting young patients remains controversial, and the well‐known etiological factors for oral cancer, tobacco, and alcohol use are believed to play a minor role in the carcinogenesis of the neoplasm, suggesting that the etiology and the molecular basis of OSCC may differ between younger and older patients. Although several molecular markers and chromosomal abnormalities have been demonstrated to differ between both groups, most of the studies have failed to find significant differences. Moreover, divergent results have also been obtained regarding the presence of high‐risk human papillomavirus infection in OSCC of young patients. Given these contradictory results and the limited methodological approaches of the majority of the studies, the exact difference between both age groups remains to be fully established. In this review, we evaluate the available data to establish the current evidence that might support the hypothesis that the molecular basis of OSCC in young patients (especially those under 40 years) differ from the older patients.

Etiology

Pathogenesis

Age groups

10.1111/jop.12642

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Citations (51)

A multicenter study of oral sarcomas in Brazil

Oral Diseases (2019)

Waldner Ricardo Souza de Carvalho Lucas Lacerda de Souza Flávia Sirotheau Corrêa Pontes Daniel Cavalléro Colares Uchôa Davi Lavareda Corrêa

The aim of this study was to investigate the prevalence of oral sarcomas from geographic regions of Brazil.A cross-sectional study was conducted on biopsies obtained from January 2007 to December 2016 at twelve Brazilian oral and maxillofacial pathology centres. Gender, age, evolution time, clinical aspects, tumour location, tumour size at diagnosis, radiographic aspects and histopathological diagnosis were evaluated. Data were analysed using descriptive statistical methods.From 176,537, a total of 200 (0.11%) oral sarcomas were reported, and the most prevalent were osteosarcomas (74 cases; 37%) and Kaposi's sarcomas (52 cases; 26%). Males were more affected than females at a mean age of 32.2 years old (range of 3-87 years). The most common symptoms were swelling¸ localised pain and bleeding at a mean evolution time of 5.14 months (range <1-156 months). The lesions were mostly observed in the mandible (90 cases; 45%), with a mean tumour size of 3.4 cm (range of 0.3-15 cm). Radiographically, the lesions presented a radiolucent aspect showing cortical bone destruction and ill-defined limits.Oral sarcomas are rare lesions with more than 50 described subtypes. Osteosarcomas and Kaposi's sarcomas were the main sarcomas of the oral cavity in Brazil.

Radiodensity

Bone Sarcoma

10.1111/odi.13211

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Citations (30)

DNA Methylation patterns of immune response-related genes in inflammatory external root resorption

Figshare (2021)

Daniela Augusta Barbato Ferreira Sara Ferreira dos Santos Costa Ricardo Santiago Gomez Juliana Vilela Bastos

Abstract Inflammatory external root resorption (IERR) is a pathological process defined by the progressive loss of dental hard tissue, dentin, and cementum, resulting from the combination of the loss of external root protective apparatus and root canal infection. It has been suggested that healing patterns after tooth replantation may be influenced by the genetic and immunological profiles of the patients. The purpose of the present investigation was to evaluate the DNA methylation patterns of 22 immune response-related genes in extracted human teeth presenting with IERR. Methylation assays were performed on samples of root fragments showing IERR and compared with healthy bone tissue collected during the surgical extraction of impacted teeth. The methylation patterns were quantified using EpiTect Methyl II Signature Human Cytokine Production PCR Array. The results revealed significantly higher hypermethylation of the FOXP3 gene promoter in IERR (65.95%) than in the bone group (23.43%) (p < 0.001). The ELANE gene was also highly methylated in the pooled IERR sample, although the difference was not statistically significant (p= 0.054). Our study suggests that the differential methylation patterns of immune response-related genes, such as FOXP3 and ELANE, may be involved in IERR modulation, and this could be related to the presence of root canal infection. However, further studies are needed to corroborate these findings to determine the functional relevance of these alterations and their role in the pathogenesis of IERR.

Inflammatory response

10.6084/m9.figshare.14287666

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Author response for "Pleomorphic adenoma and carcinoma ex‐pleomorphic adenoma tumorigenesis: A proteomic analysis"

Virgílio Gonzales Zanella Sara Ferreira dos Santos Costa Lauren Frenzel Schuch Emily Ferreira Salles Pilar Adriana Franco Paes Leme

10.1111/odi.15109/v2/response1

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Ganglion Cyst of the Temporomandibular Joint: a Case Report

Oral Surgery Oral Medicine Oral Pathology and Oral Radiology (2018)

Sara Ferreira dos Santos Costa Tatiana Fernandes Araújo Almeida Felipe Eduardo Baires Campos Wagner Henriques de Castro Felipe Paiva Fonseca

Ganglion cyst

Dense connective tissue

10.1016/j.oooo.2018.02.127

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Perfil de metilação de genes relacionados à apoptose emameloblastomas

Sara Ferreira dos Santos Costa

O ameloblastoma e um tumor odontogenico epitelial benigno e seus dois subtipos mais comuns sao: multicistico/solido e unicistico. Varias via moleculares podem estar alteradas no ameloblastoma incluindo a apoptose que e um processo fundamental na cinetica das celulas tumorais. As mudancas epigeneticas, como a metilacao do DNA, podem atuar na regulacao de genes relacionados a esse tipo de morte celular.Entretanto, nao ha dados na literatura sobre o perfil de metilacao de genes envolvidos nas vias apoptoticas em ameloblastoma. O presente estudo objetivou identificar o perfil de metilacao de genes relacionados a apoptose no ameloblastoma. Para isso foram utilizadas as tecnicas de digestao enzimatica de restricao e real-time PCR array em 22 genes associados a apoptose utilizando amostras teciduais frescas (14 ameloblastomas e 08 foliculos pericoronarios). Os genes que apresentaram uma alteracao no perfil de metilacao (TNFRSF25 e BCL2L11) foram validados atraves da analise da expressao dos seus mRNAs. A analise da expressao foi realizada utilizando GraphPad Prism 6.0 e o valor de p0.05 foi considerado estatisticamente significante.O TNFRSF25 mostrou menores niveis de metilacao nos ameloblastomas em comparacao com o foliculo pericoronario. A expressao desse gene foi maior nos ameloblastomas que nos tecidos normais. O BCL2L11 apresentou maior nivel de metilacao nos grupos de ameloblastoma unicistico e foliculo pericoronario quando comparados ao ameloblastoma multicistico. Os niveis de expressao desse gene tambem foram maiores nos tumores que nos controles. BCL2L11, comumente denominado Bim, e um membro pro-apoptotico da familia de proteinas Bcl-2. Por outro lado, o TNFRSF25 ou receptor de morte 3 (DR3) primariamente leva a ativacao de NF-kB e de vias das MAPKs e apenas em alguns casos resulta na apoptose. No presente estudo, a expressao elevada de BCL2L11/Bim e de TNFRSF25/DR3 nosameloblastomas quando comparados aos tecidos normais pode estar relacionada tanto a apoptose quanto a proliferacao das celulas tumorais do ameloblastoma.

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GLOBAL PROTEOMIC PROFILING REVEALS METABOLIC REPROGRAMMING IN AMELOBLASTOMAS

Oral Surgery Oral Medicine Oral Pathology and Oral Radiology (2022)

Sara Ferreira dos Santos Costa Jéssica Gardone Vitório Filipe Fideles Duarte‐Andrade Marina Gonçalves Diniz Carolina Cavaliéri Gomes

Reprogramming

Profiling (computer programming)

10.1016/j.oooo.2022.01.605

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Citations (3)