Mohamadreza Afarineshkhaki

Kerman University of Medical Sciences

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Saeed Azizolahi

Kerman University of Medical Sciences

Somaye Arabzadeh

Sadra Institute Of Higher Education

Ali Shamsizadeh

Rafsanjan University of Medical Sciences

Vahid Sheibani

Kerman University of Medical Sciences

Hossein Aminizadeh

Shahid Beheshti University of Medical Sciences

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Kerman University of Medical Sciences

Sadra Institute Of Higher Education

Roozbeh Hospital

Tehran University of Medical Sciences

University of Tehran

Rafsanjan University of Medical Sciences

Endocrinology Research Center

Institute of Basic Medical Sciences of the Chinese Academy of Medical Sciences

Iran National Science Foundation

University of Oxford

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Effect of norepinephrine depletion on induction of experience dependent plasticity in male rats barrel cortex

Physiology and Pharmacology (2008)

Vahid Sheibani Somaye Arabzadeh Mohamadreza Afarineshkhaki Ali Shamsizadeh Hossein Aminizadeh

Introduction: Barrel cortex of rats is a part of somatosensory cortex, which receives information from facial whiskers. Vibrisectomy by sensory deprivation leads to changes in the barrel cortex, which is known as experience dependent plasticity. On the other hand, Norepinephrine (NE) and locus coeruleus as the main source of NE, modulate response properties of cortical barrel neurons. In this study, the effect of NE depleted and sensory deprivation on induction of experience dependent plasticity was investigated. Methods: In this study sixty Wistar rats (250±25g) were used. Rats were divided into four groups: 1.Control group 2. NE depleted group (Norepinephrine was selectively depleted by IP injection of DSP4). 3. Sensory deprivation group (all whiskers except the whisker D2 on the left side were trimmed every other day). 4. NE depleted + sensory deprivation group. Excitatory (magnitude and latency) and inhibitatory (Conditioning Test Ratio, CTR index) receptive fields of barrel cortical neurons were assessed Using extracellular single unit recordings. Results: Sensory deprivation led to an increase both in the magnitude of response to principle whisker deflection (spared whisker) and in the CTR. In NE depleted + sensory deprivation group, the response magnitude and CTR index were the same as control group. Conclusion: The result showed that experience dependent plasticity has a facilitating effect on excitatory receptive field while decreasing the inhibitory circuits in the brain. When NE content of the brain was depleted before sensory deprivation, these changes were not seen. We conclude that NE depletion inhibits the plastic changes in the response properties of neurons following sensory deprivation.

Barrel cortex

Sensory deprivation

Locus coeruleus

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