Elena S. Chernetsova

University of Giessen

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Gertrud E. Morlock

University of Giessen

РА

Р. А. Абрамович

Lomonosov Moscow State University

I. A. Revelsky

Lomonosov Moscow State University

ИА

И. А. Ревельский

Lomonosov Moscow State University

МВ

М. В. Овчаров

Endocrinology Research Center

ПО

П. О. Бочков

Russian Medical Academy of Continuous Professional Education

A. I. Revelsky

Lomonosov Moscow State University

ГВ

Г. В. Затонский

Gause Institute of New Antibiotics Russian Academy of Medical Sciences

Tim Sobolevsky

University of California, Los Angeles

ГА

Г. А. Калабин

Peoples' Friendship University of Russia

Cooperative Institutions

Lomonosov Moscow State University

Russian Academy of Sciences

Peoples' Friendship University of Russia

Moscow State University

Russian New University

NS Kurnakova Institute of General and Inorganic Chemistry

University of Helsinki

Institute of General and Inorganic Chemistry

N.D. Zelinsky Institute of Organic Chemistry

A.V. Topchiev Institute of Petrochemical Synthesis

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High-performance liquid chromatography coupled to mass spectrometry for studying new pharmaceutical entities

Journal of Analytical Chemistry (2010)

Elena S. Chernetsova Angela G. Koryakova

Sample Preparation

10.1134/s1061934810140029

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Citations (0)

Doklady Chemistry (2001)

С.Е. Нефедов Elena S. Chernetsova А.А. Sidorov Sema L. Ioffe И.Л. Еременко

10.1023/a:1019209114212

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Citations (4)

Aspects of surface scanning by direct analysis in real time mass spectrometry employing plasma glow visualization

Rapid Communications in Mass Spectrometry (2015)

Elena S. Chernetsova Gertrud E. Morlock

Rationale Visual monitoring of the Direct Analysis in Real Time (DART) gas impact region during sampling was demonstrated via its metastable plasma glow. It is known that adding neon into helium for DART leads to plasma glow, but this effect has not been used in practice and discussed in the literature so far. Methods A single quadrupole mass spectrometer with a DART SVPA ion source was used for recording of DART mass spectra from different surfaces, using galangin and p ‐coumaric acid as model analytes. In specific cases, the composition of the mass spectra was clarified using an Orbitrap mass spectrometer. Results Plasma glow visualization made it possible to track the metastable gas distributions during surface scanning. The influence on the composition of the mass spectra was studied for different carrier gases, i.e. pure helium versus a helium–neon mixture, and for the vacuum pumping rate. The spatial resolution was substantially improved via a DART cap with a narrowed internal diameter, but impaired by a decreased sensitivity. Comparably low signal intensities were obtained for analytes on porous layers due to analyte penetration and metastable gas scattering. Conclusions Visualization through the plasma glow enables the optimal selection of the coordinates for DART‐MS analysis and thus it will support scanning and imaging MS on surfaces, including porous planar chromatographic separation materials. Copyright © 2015 John Wiley & Sons, Ltd.

DART ion source

Dart

Glow discharge

Quadrupole mass analyzer

10.1002/rcm.7221

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Citations (12)

Determination of polychlorinated dibenzo‐p‐dioxins, dibenzofurans, and biphenyls by gas chromatography/mass spectrometry in the negative chemical ionization mode with different reagent gases

Mass Spectrometry Reviews (2002)

Elena S. Chernetsova A. I. Revelsky I. A. Revelsky Ilya A. Mikhasenko Tim Sobolevsky

Abstract I. Introduction 374 II. Approaches to Selective and Sensitive GC/MS Determination of PCDD, PCDF, and PCB 374 A. Most Prevalent Ionization Modes in GC/MS 374 B. Sensitive Detection: Negative Chemical Ionization with Different Reagent Gases 375 1. Determination of Polychlorinated Dibenzo‐ p ‐dioxins (PCDDs) and Dibenzofurans (PCDFs) with Different Reagent Gases 376 a. CH 4 as reagent gas 376 b. O 2 as reagent gas 377 c. O 2 as reagent gas [atmospheric pressure chemical ionization (APCI)] 378 d. CH 4 /O 2 as reagent gas 379 e. CH 4 /N 2 O as reagent gas 380 f. i‐C 4 H 10 /CH 2 Cl 2 /O 2 as reagent gas 380 g. Ar/CH 4 , CH 4 , i‐C 4 H 10 as reagent gases 381 h. H 2 as reagent gas 381 i. Ar, Xe, SF 6 , H 2 , and He as reagent gases 381 2. Determination of Polychlorinated Biphenyls (PCBs) with Different Reagent Gases 382 a. CH 4 and CH 4 /O 2 as reagent gases 382 b. O 2 as reagent gas [atmospheric pressure chemical ionization (APCI)] 382 c. CH 4 and NH 3 as reagent gases 383 d. CH 4 /O 2 , Ar/O 2 , CH 4 /H 2 O, and CH 4 as reagent gases 383 III. Conclusion and Actual Problems 383 References 385 Reagent gases that are used in mass spectrometry in the NCI mode for the determination of polychlorinated dibenzo‐p‐dioxins (PCDDs), dibenzofurans (PCDFs), and biphenyls (PCBs) are discussed. Ion‐molecule reactions and respective characteristic ions that form while using reagent gases (CH 4 , O 2 , i‐C 4 H 10 , NH 3 , H 2 , He, Ar, Xe, SF 6 ) or gas mixtures (CH 4 /O 2 , Ar/CH 4 , CH 4 /H 2 O, Ar/O 2 , i‐C 4 H 10 /CH 2 Cl 2 /O 2 ) are reviewed. It is shown that only CH 4 , O 2 , CH 4 /O 2 , and CH 4 /N 2 O are widely used and well studied, even though—in the case of these reagent gases—there are contradictions between the publications of various authors. Such reagent gases as NH 3 and He are not well studied, but further investigations of their use for the determination of organochlorine pollutants could be of interest. The possibilities of more sensitive and selective determination of PCDDs, PCDFs, and PCBs are discussed. © 2003 Wiley Periodicals, Inc., Mass Spec Rev 21:373–387, 2002; Published online in Wiley InterScience ( www.interscience.wiley.com ). DOI 10.1002/mas.10037

Atmospheric-pressure chemical ionization

10.1002/mas.10037

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Citations (29)

An ultra superfast identification of low-molecular components of pharmaceuticals by DART mass spectrometry

Journal of Analytical Chemistry (2010)

Elena S. Chernetsova П. О. Бочков М. В. Овчаров Г. В. Затонский Р. А. Абрамович

Dart

DART ion source

Identification

10.1134/s1061934810140157

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Citations (3)

Assessing the capabilities of direct analysis in real time mass spectrometry for 5-hydroxymethylfurfural quantitation in honey

International Journal of Mass Spectrometry (2012)

Elena S. Chernetsova Gertrud E. Morlock

Dart

DART ion source

5-hydroxymethylfurfural

10.1016/j.ijms.2012.01.012

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Citations (59)

НОВЫЙ СПОСОБ СКРИНИНГА ТАБЛЕТИРОВАННЫХ ЛЕКАРСТВЕННЫХ ПРЕПАРАТОВ НА ФАЛЬСИФИКАТЫ С ИСПОЛЬЗОВАНИЕМ МАСС-СПЕКТРОМЕТРИИ DART

Химико-фармацевтический журнал (2011)

Elena S. Chernetsova П. О. Бочков Г. В. Затонский Р. А. Абрамович

The possibility of using the DART mass spectrometry for the identification of active components in tableted drugs has been studied. The results of analysis of some drugs such as glycin, nootropil, anaprilin, mexidol, and biseptol are presented. Benefits and limitations of the DART mass spectrometry in application to fast screening of tableted pharmaceuticals for detecting counterfeits are discussed.

Dart

DART ion source

Identification

10.30906/0023-1134-2011-45-5-50-52

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PHYTOCHEMICAL ANALYSIS USING DIRECT ANALYSIS IN REAL TIME HIGH RESOLUTION MASS SPECTROMETRY

Reviews on Clinical Pharmacology and Drug Therapy (2012)

Elena S. Chernetsova Elizabeth A. Crawford Alexander N. Shikov Olga N. Pozharitskaya В. Г. Макаров

Phytochemical

10.17816/rcf10240

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Gas chromatography of organic mixtures using an atomic emission detector

Journal of Analytical Chemistry (2010)

Elena S. Chernetsova A. I. Revel’skii И. А. Ревельский Yu. A. Zolotov

Atomic emission spectroscopy

Scope (computer science)

10.1134/s1061934810080022

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Citations (7)

Масс-спектрометрия DART: быстрый анализ мягких лекарственных форм

Химико-фармацевтический журнал (2011)

Elena S. Chernetsova Р. А. Абрамович И. А. Ревельский

Рассмотрена возможность применения метода масс-спектрометрии DART для быстрого анализа мягких лекарственных форм. Представлены результаты исследования мазей «Тетрациклин», «Линимент синтомицина», «Левомеколь» и суппозиториев на основе твердого жира. Обсуждаются возможности использования данного метода для быстрого скрининга лекарственных препаратов на фальсификаты. Возможность анализа суппозиториев методом масс-спектрометрии DART показана впервые.

Dart

10.30906/0023-1134-2011-45-11-49-51

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