Linqi Chen

Soochow University

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Ting Chen

Guangdong Medical College

Rongrong Xie

Soochow University

Haiying Wu

Soochow University

Xiuli Chen

Guangxi Academy of Fishery Sciences

Feihong Luo

Children's Hospital of Fudan University

Chunxiu Gong

Beijing Children’s Hospital

Hongxing Dong

Shanghai Institute of Optics and Fine Mechanics

Ruimin Chen

Fujian Medical University

Hui Sun

Jiaxing University

Fengyun Wang

Soochow University

Cooperative Institutions

Soochow University

107

Chinese Academy of Sciences

Capital Medical University

Fudan University

Shanghai Jiao Tong University

Sun Yat-sen University

University of Chinese Academy of Sciences

Huazhong University of Science and Technology

Chinese Academy of Medical Sciences & Peking Union Medical College

Nanjing Medical University

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The subjective quality of life and parental nurturing in children with type 1 diabetes mellitus treated with conventional subcutaneous insulin or with insulin pump therapy

The Journal of clinical Pediatrics (2008)

Linqi Chen

Objectives To investigate the differences in the subjective quality of life and the parental nurturing among patients with diabetes mellitus treated with conventional subcutaneous insulin,patients treated with insulin pump and normal controls;and to investigate the risk factors affecting the quality of life. Methods Subjective quality of life were evaluated in 42 patients with type 1 diabetes mellitus and 26 normal controls by using Egma Minnenav Bardndosna Uppforstran and the Inventory of Subjective Life Quality for Child and Adolescent. Risk factors influencing the quality of life were analyzed with multiple linear regression. Results The quality of life score of the patients was lower than that of the controls. The score of school life, depressed experience,anxious experience,emotion and general satisfaction were higher in patients using insulin pump than those on conventional injection therapy(P 0.05). The comparison of parental nurturing between patients and normal controls revealed that the patients more likely to get caring understanding,excessive protection,and emotional support from their parents than normal controls. There was a significant relationship between father’s care,treatment method and patients’ quality of life. Conclusions The quality of life in children with type 1 diabetes mellitus was decreased. Father’s love and insulin pump therapy may be helpful in improving the quality of life.

Insulin pump

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Citations (3)

Cavity‐Enhanced Superfluorescence Stimulates Coherent Energy Transfer in a Perovskite Quantum Dot Superlattice

Laser & Photonics Review (2024)

Yong‐Sheng Hu Danqun Mao Linqi Chen Yuanjun Guan Long Zhang

Abstract The exploration of cooperative states in many‐body systems is a key research area. It focuses on superfluorescence (SF), a phenomenon linked with radiative dipole coupling, and its intersection with classical lasing effects. This produces a unique lasing‐field‐hybrid cooperative dipole (LCD) state through optical cavity‐enhanced superfluorescence (CESF). A coherent energy transfer is demonstrated between two such states within a perovskite quantum dot (QD) superlattice. This results in competitive luminescence timing dynamics. The findings reveal that stimulated energy transfer occurs when two cooperative cavity‐exciton states coexist, controllable via a dual‐pulse pump technique. This understanding is vital for advancing quantum phenomena knowledge and enhancing optoelectronic devices.

10.1002/lpor.202400650

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Rydberg State Single-Mode Polariton Lasing with Ultralow Threshold via Symmetry Engineering

Nano Letters (2023)

Liqing Zhu Yichun Pan Linqi Chen Zheng Wang Fangxin Zhang

Symmetry plays an essential role in the fundamental properties of a physical system. In this work, we report on the realization of tunable single-mode polariton lasing from highly excited Rydberg states via symmetry engineering. By breaking the symmetry of the polaritonic wave function through potential wells and controlling the spatial overlap between the gain region and the eigen mode, we are able to generate single-mode polariton lasing, reversibly and dynamically, from quantized polariton states. Increasing the asymmetry of the potential well, single-mode lasing can be achieved even for the highly excited Rydberg state with a principle quantum number of N = 14. Moreover, as a result of the excellent reservoir-eigen mode overlap and efficient spatial confinement, the threshold of lasing can be reduced up to 6 orders of magnitude, compared with those conventional pumping schemes. Our results present a new strategy toward the realization of thresholdless polariton lasing with dynamical tunability.

Realization (probability)

10.1021/acs.nanolett.3c01188

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The clinical analysis of small supernumerary marker chromosomes in 17 children with mos 45,X/46,X,+mar karyotype

Oncology Letters (2017)

Hongying Wang Ting Wang Naichao Yang Ya-xiang He Linqi Chen

Small supernumerary maker chromosome (sSMC) is a type of structurally abnormal chromosome. In order to identify the origin, morphology and other characteristics of sSMCs in children with mos 45,X/46,X,+mar karyotype, 17 patients (16 females and 1 male) were analyzed. All patients underwent general physical examination, gonadal imaging and molecular cytogenetic analyses, including Giemsa banding, dual‑color fluorescence in situ hybridization and detection of the sex‑determining region Y gene by polymerase chain reaction. Cytogenetic analyses indicated sSMCs in 14/17 cases were derived from the X chromosome, of which 8 individuals presented with ring‑shaped sSMCs and 6 with centric minute‑shaped sSMCs. The remaining 3 cases were derived from the Y chromosome, and all presented with minute‑shaped sSMCs. All female patients exhibited short stature, gonadal dysgenesis and other typical features of Turner syndrome. The male patient exhibited short stature, hypospadias and bilateral cryptorchidism. In conclusion, the majority of the sSMCs in patients with a mos 45,X/46,X,+mar karyotype were derived from the sex chromosomes. The molecular cytogenetic features of sSMCs may provide useful information for genetic counseling, prenatal diagnosis and individualized treatment.

Isochromosome

Gonadal dysgenesis

Ring chromosome

Marker chromosome

10.3892/ol.2017.5965

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Citations (7)

Stable Multi‐Wavelength Lasing in Single Perovskite Quantum Dot Superlattice

Advanced Optical Materials (2022)

Linqi Chen Beier Zhou Yingjie Hu Hongxing Dong Ge Zhang

Abstract Single perovskite alloy micro‐nano structure capable of emitting multi‐wavelength tunable lasing is desirable for its potential application in highly integrated photonic devices. However, owing to the soft and dynamic crystal lattice of perovskite and the low mobility energy of halide anion, it is still a challenge to obtain alloy micro‐nano structures with a stable bandgap gradient. Herein, based on the highly ordered superlattice consisting of well‐separated individual quantum dots and precise anion exchange strategy, a single perovskite alloy superlattice is obtained with a widely tunable bandgap. The photoluminescence (PL) spectra results indicate that the stability of the bandgap difference of the alloy superlattice sample is approximately 10 times higher than that of the previously reported perovskite single‐crystal alloy nanowires. By combination of quantitative study based on confocal PL measurements and theoretical calculations, the kinetics and atomic‐scale anion exchange mechanism are analyzed, the latter being responsible for the formation of stable bandgap gradient in the alloy superlattice. Multi‐wavelength lasing is further realized in single alloy superlattice. In addition, carrier transportation dynamics reveals the energy‐transfer process in the alloy superlattice, explaining the difficulties of realizing multicolor lasing. The work provides a new approach to solving problems in the field of stable multicolor microlasers.

10.1002/adom.202200494

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Citations (8)

[Idiopathic infantile hypercalcemia].

PubMed (2019)

Xiaoyan Wang Fengyun Wang Wenxiang Wei Xiaozhong Li Haiying Wu

1例主诉为"体重不增2个月余，发现血钙过高半个月"的患儿就诊于苏州大学附属儿童医院内分泌遗传代谢科，患儿血浆游离钙1.57 mmol/L，总钙3.3 mmol/L，磷0.99 mmol/L，B超提示双肾钙盐沉积，全外显子基因测序发现，患儿存在SLC34A1基因c.581G>A（p.G194D）和c.627delC（p.D209Efs*77）复合杂合变异，诊断为特发性婴儿高钙血症。国内尚无SLC34A1基因变异患者报道。.

10.3760/cma.j.issn.0578-1310.2019.05.013

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Citations (1)

Chinese childrens’ diabetes status, trends and hardship

International Journal of Pediatric Endocrinology (2013)

Junfen Fu Li Liang Chunxiu Gong Feng Xiong Feihong Luo

Diabetes mellitus is now fast emerging as one of the biggest health catastrophes the world has ever witnessed. It has huge global and societal implications, particularly in developing countries such as China and India [1]. China is now bring with it potential massive increase in type 1 diabetes (2-5% per annum increases in incidence in the world's most populous countries) and childhood obesity (with its associated insulin resistance and type 2 diabetes)[2]. A nine-year prospective study on the incidence of childhood type 1 diabetes mellitus in China by the WHO DiaMond Project China Participating Center and Chinese Academy of Preventive Medicine (CAPM) showed that between 1988 and 1996, the overall incidence rate (IR) was 0.59 per 100,000 person-year. The IR was 0.52/100,000 (95% CI: 0.50-0.54) for males and 0.66/100,000 (95% CI: 0.64-0.68) for females[3]. We recently conducted a nationwide study to evaluate the state and the trend of diabetes based on hospital inpatient data from China’s 14 medical centers and pre-diabetes among obese children from October 1995 through September 2010. We found that in the past 15 years, the prevalence of Chinese childhood diabetes increased dramatically and the growth of T2DM has exceeded T1DM. T1DM has occurrence rate of 89.6% of all diabetes and is still the dominant form of diabetes in children. The prevalence of T1DM was relatively stable from the year of 1995 to 2005, but increased obviously in the recent 5 years according to the hospital records in China. The clear increasing trend from Southwest to East and North disclosed strong regional differences (T1DM from 59.76 to 80.02 and 120.45, T2DM from 2.52 to 3.77 and 15.64 (1/100,000) (p all < 0.0001). Well developed areas had a higher prevalence compared to less developed areas {T1DM: 151.51 vs. 32.2; T2DM: 15.16 vs. 1.64 and other types: 7.54 vs. 0.42 (1/100,000)}. An important finding in this study is that the prevalence of childhood T2DM in China doubled from 4.1/100,000 in the first 5 years to 10.0/100,000 in the recent 5 years, which was 7.44 % of total diabetics. Though the ratio is still lower than that of America (8%-46%)[4] , the trend is clear and the consequences are serious because China has the largest population in the world. Another important finding in this study showed obese children are potential pools of T2DM. Of the 3153 obese children, 18.24% had IFG alone, 5.99% had IGT, 4% had combined IFG and IGT.

10.1186/1687-9856-2013-s1-o13

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Citations (1)

Serum Antimullerian Hormone and Inhibin B as Potential Markers for Progressive Central Precocious Puberty in Girls

The Japanese Society for Pediatric Endocrinology (2016)

Ting Chen Linqi Chen Haiying Wu Rongrong Xie Xiuli Chen

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[Clinical and genetic analysis of five Chinese pedigrees affected with short stature due to variants of ACAN gene].

PubMed (2021)

Xiaoyan Wang Rongrong Xie Haiying Wu Xiuli Chen Fengyun Wang

To analyze the clinical and genetic characteristics of five Chinese pedigrees affected with short stature.A retrospective analysis was carried out for the clinical data and results of genetic testing for the probands. A literature search was also conducted.The five probands have all featured short stature with a family history. Genetic testing has revealed that they have harbored variants of the ACAN gene, including p.Val2042Argfs*6, p.Val1597del, c.630-1G>A, c.23delT and c.2026+1G>A(previously reported).Except for short stature, children harboring heterozygous variants of the ACAN gene may have no involvement of other systems. Some of these children may response to short-term growth hormone treatment.

Pedigree chart

Proband

Genetic Analysis

Body height

10.3760/cma.j.cn511374-20201021-00737

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Citations (1)

Solution Method and Application Verification of the K-curve as a Highway Transition Curve

KSCE Journal of Civil Engineering (2021)

Binghong Pan Changpeng Wen Kaiming Wang Changjiang Liu Linqi Chen

Parametric equation

Chord (peer-to-peer)

Osculating circle

Arc length

10.1007/s12205-021-2193-0

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Citations (1)