Chien‐Ping Chiang

Tri-Service General Hospital

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Wei‐Ming Wang

National Defense Medical Center

Chih‐Tsung Hung

National Defense Medical Center

Hong‐Wei Gao

Lanzhou University Second Hospital

Yi‐Hsien Chen

Washington University in St. Louis

Shiao‐Pieng Lee

National Defense Medical Center

Bai‐Yao Wu

National Defense Medical Center

Jeng‐Feng Chen

Tri-Service General Hospital

Chi‐Hsiang Chung

Taiwan Nurses Association

Wu‐Chien Chien

National Defense Medical Center

Shih‐Jiun Yin

National Defense Medical Center

Cooperative Institutions

National Defense Medical Center

164

Tri-Service General Hospital

129

National Yang Ming Chiao Tung University

National Taiwan University

Taipei Veterans General Hospital

China Medical University

National Taiwan University Hospital

National Taipei University

Academia Sinica

Taipei Medical University

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Hormone replacement therapy did not increase risk of melanoma in Chinese female with menopausal and postmenopausal disorders: A population‐based retrospective cohort study in Taiwan

The Journal of Dermatology (2023)

Jun Ma Yi‐Hsien Chen Chien‐Ping Chiang Wei‐Ming Wang Chi‐Hsiang Chung

Hormone replacement therapy (HRT) is widely used to relieve symptoms of menopause with proven efficacy. However, there has been significant controversy surrounding the use of HRT because of its potential link with an increased risk of cancer, particularly female reproductive organ cancers. That HRT increases the risk of melanoma is also disputed, and several cohort studies have produced variable results. To delineate the association between HRT and melanoma in Taiwan, we conducted a population-based retrospective cohort study on 14 291 patients who had received HRT and 57 164 population controls in Taiwan between 2000 and 2013. Multivariate odds ratios (ORs) were calculated utilizing conditional logistic regression. Overall, the use of HRT was not significantly correlated with a higher risk of developing melanoma in Taiwan (95% confidence interval 0.386-1.099; p = 0.341). The hazard ratio analysis of melanoma and different HRTs showed there was no significant association between melanoma and the use of oral or external estrogens alone, including conjugated estrogens, estradiol, and estriol. Estrogen plus progesterone combined therapy was associated with a lower risk of melanoma. Only one case of melanoma was observed among the 2880 patients in this subgroup.

10.1111/1346-8138.16859

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Citations (0)

Amyloidosis cutis dyschromica: four cases from two families

International Journal of Dermatology (2009)

Wei‐Hsuan Huang C. Y. Wu Cheng‐Ping Yu Chien‐Ping Chiang

General hospital

Chiang mai

10.1111/j.1365-4632.2009.03844.x

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Citations (22)

Wells’ syndrome associated with Churg-Strauss syndrome: correlation with mast cell distribution

International Journal of Dermatology (2012)

Ching‐Fu Huang Yufei Chen Wei‐Ming Wang Chien‐Ping Chiang

General hospital

10.1111/j.1365-4632.2011.05159.x

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Citations (4)

Multiple Painful Ulcers of a 42-year-old Man

中華皮膚科醫學雜誌 (2008)

Wei-Hsuan Huang陳宇欽 Chien‐Ping Chiang

10.29784/ds.200809.0009

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Citations (1)

Primary localized cutaneous nodular amyloidosis on areola

Indian Journal of Dermatology Venereology and Leprology (2022)

Shengwen Liu Chih‐Tsung Hung Hong‐Wei Gao Chien‐Ping Chiang Chih‐Yu Chen

Areola

Primary (astronomy)

10.25259/ijdvl_491_2021

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Citations (2)

Multiple Vegetating Granulomatous Nodules in a 94-year-old Man

中華皮膚科醫學雜誌 (2008)

Yi-Chieh Lin Chien‐Ping Chiang

CASE REPORT A 94-year-old male patient presented with multiple vegetating and granulomatous nodules on the right groin and gluteal region in the recent one year (Fig. 1A). He was robust before without any other systemic diseases except oral erosion developed one week before he visited our clinic. Tentative diagnosis included cutaneous fungal infection, cutaneous T cell lymphoma, and vegetating blistering disease. Bacterial and fungal culture showed no growth of microorganism. An incisional biopsy was performed in the gluteal region and histopathology showed epidermal hyperplasia, and intraepidermal eosinophilic absecsses (Fig. 2). Direct immunofluorescence(DIF) studies of the lesion revealed intraepidermal IgG and C3 deposition (Fig. 3). Indirect immunofluorescence revealed circulating antiepithelial cell surface IgG. The patient responded well to topical occlusive clobetasol treatment and those lesions regressed a lot after one week (Fig. 1B). Resident Forum

Histopathology

Buttocks

Direct fluorescent antibody

Granulomatous disease

Groin

Paraneoplastic pemphigus

Immunofluorescence

10.29784/ds.200809.0010

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Citations (0)

Acral papular rash in a 2-year-old boy.

PubMed (2012)

Fang‐Yih Liaw Ching-Fu Huang Li-Wei Wu Chien‐Ping Chiang

Source

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Citations (1)

Mottled hyperpigmentation on the face and neck of a woman 35 years of age

Dermatologica Sinica (2012)

Chih‐Tsung Hung Hong‐Wei Gao Bai‐Yao Wu Chien‐Ping Chiang

10.1016/j.dsi.2012.02.003

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Citations (1)

Tissue distribution and subcellular localizations determine in vivo functional relationship among prostasin, matriptase, HAI-1, and HAI-2 in human skin

PLoS ONE (2018)

Shiao‐Pieng Lee Chen‐Yu Kao Shun-Cheng Chang Yi‐Lin Chiu Yen‐Ju Chen

The membrane-bound serine proteases prostasin and matriptase and the Kunitz-type protease inhibitors HAI-1 and HAI-2 are all expressed in human skin and may form a tightly regulated proteolysis network, contributing to skin pathophysiology. Evidence from other systems, however, suggests that the relationship between matriptase and prostasin and between the proteases and the inhibitors can be context-dependent. In this study the in vivo zymogen activation and protease inhibition status of matriptase and prostasin were investigated in the human skin. Immunohistochemistry detected high levels of activated prostasin in the granular layer, but only low levels of activated matriptase restricted to the basal layer. Immunoblot analysis of foreskin lysates confirmed this in vivo zymogen activation status and further revealed that HAI-1 but not HAI-2 is the prominent inhibitor for prostasin and matriptase in skin. The zymogen activation status and location of the proteases does not support a close functional relation between matriptase and prostasin in the human skin. The limited role for HAI-2 in the inhibition of matriptase and prostasin is the result of its primarily intracellular localization in basal and spinous layer keratinocytes, which probably prevents the Kunitz inhibitor from interacting with active prostasin or matriptase. In contrast, the cell surface expression of HAI-1 in all viable epidermal layers renders it an effective regulator for matriptase and prostasin. Collectively, our study suggests the importance of tissue distribution and subcellular localization in the functional relationship between proteases and protease inhibitors.

Zymogen

10.1371/journal.pone.0192632

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Citations (20)

Increased risk of cardiovascular comorbidities in hidradenitis suppurativa: A nationwide, population‐based, cohort study in Taiwan

The Journal of Dermatology (2019)

Chih‐Tsung Hung Chien‐Ping Chiang Chi‐Hsiang Chung Chang‐Huei Tsao Wu‐Chien Chien

Abstract Hidradenitis suppurativa ( HS ) has been reported to be associated with metabolic syndrome and coronary artery disease ( CAD ). Nevertheless, a nationwide study of this relationship in the Asian population has not been conducted. The aim of the present study was to clarify the cardiovascular disease risk factors, and the occurrence of CAD and cerebral infarction among patients with HS by using a nationwide database in Taiwan. We obtained data from the National Health Insurance Research Database of Taiwan. After adjusting for confounding factors, we used Cox proportional hazards analysis to reveal the risk of incident hypertension ( HTN ), diabetes mellitus ( DM ), dyslipidemia, CAD and cerebral infarction in HS patients. We identified 478 patients with newly diagnosed HS and 1912 patients in the control cohort during the 10‐year follow‐up period. Compared with the controls, HS patients had a higher risk of dyslipidemia (adjusted hazard ratio [ aHR ], 3.858; 95% confidence interval [ CI ], 2.785–5.346; P < 0.001), HTN ( aHR , 1.910; 95% CI , 1.463–2.493; P < 0.001), DM ( aHR , 1.709; 95% CI , 1.127–2.591; P = 0.012). Regarding comorbidities, our results also revealed a higher risk of CAD in HS patients ( aHR , 2.722; 95% CI , 1.628–4.553; P < 0.001), but not cerebral infarction ( aHR , 0.514; 95% CI , 0.119–2.231; P = 0.375). Our results indicate that there is a higher risk of dyslipidemia, HTN , DM and CAD in HS patients.

Dyslipidemia

Hidradenitis Suppurativa

10.1111/1346-8138.15038

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Citations (25)