Frank Biedermann

Karlsruhe Institute of Technology

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Co-Authors

Oren A. Scherman

University of Cambridge

Werner M. Nau

Constructor University

Laura Grimm

Karlsruhe Institute of Technology

E Winiker-Blanck

Stephan Sinn

Karlsruhe Institute of Technology

Chang‐Ming Hu

Guangzhou Quality Supervision, Inspection and Research Institute

Stefan Bräse

Karlsruhe Institute of Technology

Joana Krämer

Karlsruhe Institute of Technology

Luisa De Cola

Mario Negri Institute for Pharmacological Research

M Lüning

Dutch College of General Practitioners

Cooperative Institutions

Karlsruhe Institute of Technology

University of Cambridge

Friedrich Schiller University Jena

Constructor University

Centre National de la Recherche Scientifique

Institute of Nanotechnology

Karlsruhe University of Education

Leibniz Institute of Plant Biochemistry

Johannes Gutenberg University Mainz

Technische Universität Braunschweig

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[Bilateral bending of the distal joint of the little finger (Kirner's deformity)].

PubMed (1967)

M Lüning Frank Biedermann

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Tomographischer Nachweis ungewöhnlicher Traumafolgen am Axis

RöFo - Fortschritte auf dem Gebiet der Röntgenstrahlen und der bildgebenden Verfahren (1972)

G Schmidt Frank Biedermann

10.1055/s-0029-1229376

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Nichtkovalente Chiralitätssensorik‐Ensembles zur Detektion und Reaktionsverfolgung von Aminosäuren, Peptiden, Proteinen und aromatischen Wirkstoffen

Angewandte Chemie (2014)

Frank Biedermann Werner M. Nau

Abstract Ternäre Komplexe des makrocyclischen Wirts Cucurbit[8]uril mit dikationischen Farbstoffen und chiralen aromatischen Analyten zeigen starke induzierte Circulardichroismus(ICD)‐Signale im Nah‐UV‐ und sichtbaren Bereich. Dies ermöglicht eine neuartige Herangehensweise zur Chiralitätssensorik und Sequenzerkennung in Wasser mit mikromolaren Analytkonzentrationen. Chemische Reaktionen können zudem in Echtzeit verfolgt werden, da die reversible und nichtkovalente Bindung augenblicklich auf Konzentrationsänderungen anspricht. Die hier vorgestellte supramolekulare Methode eignet sich für viele bioanalytische Anwendungen, z. B. für Enzymassays, die Wirkstoffanalytik und die kontinuierliche Verfolgung enantioselektiver Reaktionen, insbesondere asymmetrischer Katalyse.

10.1002/ange.201400718

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Citations (40)

[Lumbosacral vertebral dislocation followed by spondylolisthesis].

PubMed (1972)

E. Kaiser Frank Biedermann R. Lehmann D Szdzuy

Lumbosacral joint

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[Indications for the surgical management of impression fractures of the skull].

PubMed (1975)

Siedschlag Wd Ewald Moser D Szdzuy Zain Ta Frank Biedermann

Impression

Surgical procedures

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Röntgendiagnostik der Ohrmißbildungen

Springer eBooks (1994)

Frank Biedermann

10.1007/978-3-642-85083-7_3

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Covalent cucurbit[7]uril–dye conjugates for sensing in aqueous saline media and biofluids

Chemical Science (2020)

Chang‐Ming Hu Laura Grimm Amrutha Prabodh Ananya Baksi Alicja Siennicka

Non-covalent chemosensing ensembles of cucurbit[n]urils (CBn) have been widely used in proof-of-concept sensing applications, but they are prone to disintegrate in saline media, e.g. biological fluids. We show here that covalent cucurbit[7]uril-indicator dye conjugates are buffer- (10× PBS buffer) and saline-stable (up to 1.4 M NaCl) and allow for selective sensing of Parkinson's drug amantadine in human urine and saliva, where the analogous non-covalent CB7⊃dye complex is dysfunctional. The in-depth analysis of the covalent host-dye conjugates in the gas-phase, and deionized versus saline aqueous media revealed interesting structural, thermodynamic and kinetic effects that are of general interest for the design of CBn-based supramolecular chemosensors and systems. This work also introduces a novel high-affinity indicator dye for CB7 through which fundamental limitations of indicator displacement assays (IDA) were exposed, namely an impractical slow equilibration time. Unlike non-covalent CBn⊃dye reporter pairs, the conjugate chemosensors can also operate through a SN2-type guest-dye exchange mechanism, which shortens assay times and opens new avenues for tailoring analyte-selectivity.

Conjugate

Aqueous medium

10.1039/d0sc03079a

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Citations (48)

Porous supramolecular materials: the importance of emptiness

Supramolecular chemistry (2018)

Frank Biedermann Luisa De Cola

When designing a functional system, supramolecular chemists tend to only focus ‘what should be there’, i.e., the molecules and their spatial orientation towards each other, but more rarely is the m...

Emptiness

10.1080/10610278.2017.1412015

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Citations (4)

[Arthography of the shoulder joint].

PubMed (1968)

M Lüning Katrin Arnold Frank Biedermann

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Self-Assembly in Aqueous Media

Elsevier eBooks (2016)