Omair Ali

Wills Eye Hospital

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Co-Authors

Sami H. Uwaydat

University of Arkansas for Medical Sciences

Nalini S. Bora

University of Arkansas for Medical Sciences

Valeriy V. Lyzogubov

University of Arkansas for Medical Sciences

Sunali Goyal

University of Arkansas for Medical Sciences

Alan B. Richards

Albany Medical Center Hospital

Judith C. Simon

Tamale Teaching Hospital

Catherine Liu

Wills Eye Hospital

Puran S. Bora

Life Science Institute

Ian Murdoch

University College London

R. Grant Morshedi

Little Rock Family Practice Clinic

Cooperative Institutions

University of Arkansas for Medical Sciences

Jones Institute

Arkansas Department of Agriculture

Ophthalmology Associates (United States)

Central Arkansas Veterans Healthcare System

Institute of Ophthalmology

University of Arkansas at Little Rock

Conway School of Landscape Design

Wright State University

University of Cincinnati

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Out in the cold: the hypothermic heart response

BMJ Case Reports (2014)

Yassar Nabeel Omair Ali

We present an interesting case of a 49-year-old woman with hypothermia and associated Osborn waves (also called J waves) on ECG. She was found on the floor of her home and difficult to arouse. On arrival to the emergency department (ED), her rectal temperature was 87.5°F. ECG showed Osborn waves in diffuse leads. She was intubated in the ED and was started on vasopressor support for hypotension refractory to intravenous fluid boluses. She was transferred to the critical care unit for continued respiratory and cardiovascular support. With active external rewarming her core body temperature continued to improve. Blood pressure also improved and vasopressor was tapered off. She was extubated and was transferred to the medical floor for continued supportive care. Osborn waves on ECG resolved within 12 h of achieving normal range body temperature. The patient was eventually discharged home with medical follow-up.

Core temperature

Refractory (planetary science)

Vital signs

10.1136/bcr-2014-207358

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Effect of Aspirin on models of RPE pathology: Aspirin and retinal degeneration

Sunali Goyal Valeriy V. Lyzogubov Omair Ali Nalini S. Bora Sami H. Uwaydat

Degeneration (medical)

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Outcomes of refractive surgery

Omair Ali

Refractive Surgery

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Proportion of angle closure glaucoma in Tamale, Ghana

Research Square (Research Square) (2023)

Catherine Liu Omair Ali Ian Murdoch Judith C. Simon

Abstract Background/Objectives: Glaucoma is the second leading cause of blindness worldwide. In Africa, glaucoma is an established public health problem, and primary angle-closure glaucoma (PACG) is not commonly discussed. Recognizing it is important because of its negative impact on visual morbidity, and also because its treatment is different from primary open angle glaucoma (POAG). In response to the observation of many PACG cases at the Northern Community Eye Hospital in Tamale, Ghana, we investigated the proportion of those attending with a first diagnosis of glaucoma who had PACG. Subjects/Methods: Using the electronic records, we identified 976 patients who attended with a first diagnosis of glaucoma between January 2021 and October 2022. Of these, 588 met the inclusion criterion of a clear glaucoma subtype diagnosis. Results: Of these 316 (53.7%) had POAG, 210 (35.7%) PACG, and 62 (10.5%) secondary glaucoma. Thus, over a third of presenting glaucomas had PACG. Conclusion: This highlights that PACG is present in a large proportion of our African population. Our study demonstrates the importance of a clear diagnostic pathway including gonioscopy in the assessment of glaucoma patients and the consideration of wider training on angle closure glaucoma diagnosis and management.

Gonioscopy

10.21203/rs.3.rs-2964262/v1

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Visual outcomes of herpes simplex keratitis in children age 6 years and younger

Journal of American Association for Pediatric Ophthalmology and Strabismus (2021)

Omair Ali Alan B. Richards Nick Zaunbrecher

10.1016/j.jaapos.2021.08.052

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Effect of Aspirin on Polyethylene Glycol (PEG) induced Mouse Model of Dry Age Related Macular Degeneration and Human ARPE-19 cells in vitro

Investigative Ophthalmology & Visual Science (2014)

Sunali Goyal Valeriy V. Lyzogubov Omair Ali Puran S. Bora Nalini S. Bora

Degeneration (medical)

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Xanthogranulomatous cholecystitis mimicking gallbladder cancer

BMJ Case Reports (2014)

Ofor Ewelukwa Omair Ali Salma Akram

Xanthogranulomatous cholecystitis (XGC) is a benign, uncommon variant of chronic cholecystitis characterised by focal or diffuse destructive inflammatory process of the gallbladder (GB). Macroscopically, it appears like yellowish tumour-like masses in the wall of the GB. This article reports on a 74-year-old woman with XGC mimicking GB cancer.

Gallbladder Cancer

Chronic cholecystitis

10.1136/bcr-2013-200530

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Effect of aspirin on models of retinal pigment epithelium pathology

Clinical and Experimental Ophthalmology (2016)

Sunali Goyal Valeriy V. Lyzogubov Omair Ali Puran S. Bora Nalini S. Bora

Abstract Background To characterize the effect of aspirin (ASA) in mouse models of choroidal neovascularization (CNV) and retinal degeneration. Methods In vivo : Male C57BL/6 mice were given ASA in food or regular rodent diet. CNV was induced by argon laser photocoagulation. Subretinal injections of polyethylene glycol 400 (PEG‐400) were administered to induce retinal degeneration. CNV size, laser spot area and mean intensity of VEGF in the laser injured zones were measured. In the PEG injected eyes the thickness of retinal pigment epithelium (RPE) and choroid was measured. In vitro : Human ARPE‐19 cells were treated with 0.5 or 2.0 mM/L of ASA for 72 h. ELISA was used to measure the concentration of VEGF and CCL‐2 in the supernatants. Additionally, damaged RPE monolayer was treated with ASA (0.5 or 2.0 mM/L) and vehicle separately. Size of damaged area was measured. ELISA was used to measure secretion of VEGF‐A and CCL‐2 by damaged cells after 24 h. Results No statistically significant effect of ASA on CNV size, laser spot size or VEGF expression was noted in CNV model. In the PEG model, ASA did not have any effect on RPE and choroid thickness; however, a significant increase in RPE atrophy was observed ( P = 0.02 + 38%). In addition, ASA had a significant effect on the ability of the RPE cells to regenerate and become confluent after mechanical damage. Conclusions ASA at doses consumed clinically for various medical causes may not worsen CNV in human subjects. However, ASA may increase RPE atrophy when consumed over long periods of time.

Choroid

10.1111/ceo.12721

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Proportion of Angle Closure Glaucoma in Tamale, Ghana

Journal of Glaucoma (2024)

Catherine Liu Omair Ali Ian Murdoch Judith C. Simon

Précis: In the largest clinic-based study to date, our review of 588 patients presenting with glaucoma in Northern Ghana revealed 36% of these had primary angle closure glaucoma (PACG). Objective: Glaucoma is the second leading cause of blindness worldwide. In Africa, glaucoma is an established public health problem, and PACG is not commonly discussed. Recognizing it is important because of its negative impact on visual morbidity, and also because its treatment is different from primary open angle glaucoma. In response to the observation of many PACG cases at the Northern Community Eye Hospital in Tamale, Ghana, we investigated the proportion of those attending with a first diagnosis of glaucoma who had PACG. Patients and Methods: Using the electronic records, we identified 976 patients who attended with a first diagnosis of glaucoma between January 2021 and October 2022. Of these, 588 met the inclusion criterion of a clear glaucoma subtype diagnosis. Results: Of these 316 (53.7%) had primary open angle glaucoma, 210 (35.7%) PACG, and 62 (10.5%) secondary glaucoma. Thus, over a third of presenting glaucomas had PACG. Conclusion: This study highlights that PACG is present in about a third of patients presenting to our clinic in North Ghana. Our study demonstrates the importance of a clear diagnostic pathway including gonioscopy in the assessment of glaucoma patients and the consideration of wider training on angle closure glaucoma diagnosis and management.

Gonioscopy

10.1097/ijg.0000000000002383

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Optimal dosing of trimethoprim sulfamethoxazole in outpatient treatment of preseptal orbital cellulitis

Journal of American Association for Pediatric Ophthalmology and Strabismus (2021)

Alan B. Richards Omair Ali Matthew Williams

Trimethoprim

Sulfamethoxazole

Orbital cellulitis

10.1016/j.jaapos.2021.08.168

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