Neci Matos Soares

Universidade Federal da Bahia

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Márcia Cristina Aquino Teixeira

Universidade Federal da Bahia

Joelma Nascimento de Souza

Universidade Federal da Bahia

Nilo Manoel Pereira Vieira Barreto

Hospital Ana Nery

Flávia Thamiris Figueiredo Pacheco

Universidade Federal da Bahia

Fred Luciano Neves Santos

Fundação Oswaldo Cruz

Wéslei Almeida Costa Araújo

Universidade Federal da Bahia

C. Oliveira

Universidade Federal da Bahia

Elizabete de Jesus Inês

Universidade Federal da Bahia

Noilson Lázaro Gonçalves

Fundação Oswaldo Cruz

Tereza Cristina Medrado Ribeiro

Complexo Hospitalar Universitário Professor Edgard Santos

Cooperative Institutions

Universidade Federal da Bahia

112

Fundação Oswaldo Cruz

Hospital Ana Nery

Complexo Hospitalar Universitário Professor Edgard Santos

Escola Bahiana de Medicina e Saúde Pública

Universidade Salvador

Fundação Carlos Chagas

Universidade Federal Fluminense

Instituto de Saúde

Fundação Bahiana de Infectologia

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Performance of microscopy and ELISA for diagnosing Giardia duodenalis infection in different pediatric groups

Parasitology International (2016)

Renata K. N. R. Silva Flávia Thamiris Figueiredo Pacheco Adson Santos Martins Joelma Figueiredo Menezes Hugo Costa‐Ribeiro

Giardia

Giardia lamblia

Entamoeba

Concordance

Parasitology

10.1016/j.parint.2016.08.012

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Citations (26)

Case Report: Strongyloides stercoralis Hyperinfection in a Patient with HTLV-1: An Infection with Filariform and Rhabditiform Larvae, Eggs, and Free-Living Adult Females Output

American Journal of Tropical Medicine and Hygiene (2018)

Joelma Nascimento de Souza Bárbara Nascimento Rocha Ribeiro Soares Luana Leandro Goes Cintia de Souza Lima Nilo Manoel Pereira Vieira Barreto

Strongyloides stercoralis is the main etiological agent of human strongyloidiasis. Severe strongyloidiasis is commonly associated to alcoholism, corticostereoid use, and human T cell lymphotropic virus type 1 (HTLV-1) coinfection. Herein, we report a case of a 13-year-old boy coinfected with S. stercoralis and HTLV-1, excreting several parasitic forms in the stool. The parasitological examination of his feces showed a large amount of filariform (about 3,000 larvae per gram of feces) and rhabditiform larvae (about 2,000 larvae per gram of feces). In addition, free-living adult females (about 50 parasites per gram of feces) and eggs (about 60 eggs per gram of feces) were detected. The main laboratory findings pointed to high immunoglobulin E (IgE) levels (228 UI/mL) and eosinophila (11.6%). The patient was treated with three courses of ivermectin (200 µg/kg twice, 2 weeks apart), achieving the parasitological cure. An increase of about 19 times in interleucin (IL)-17 level was observed following the parasitological cure, in addition to a decrease in the white blood cell, eosinophil counts, and IgE levels. This is the first case report, to our knowledge, in which an S. stercoralis adult free-living female was described in human feces and where an increase in IL-17 levels after Strongyloides treatment in a HTLV-1 coinfected individual was observed. This finding raises the need for further studies about IL-17 immunomodulation in S. stercoralis and HTLV-1 coinfected patients.

Strongyloides stercoralis

Strongyloidiasis

Strongyloides

Eggs per gram

10.4269/ajtmh.18-0402

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Citations (19)

Cryptosporidium diagnosis in different groups of children and characterization of parasite species

Revista da Sociedade Brasileira de Medicina Tropical (2022)

Flávia Thamiris Figueiredo Pacheco Humberto Fonseca de Freitas Renata Kelly Novais Rodrigues Silva Silvia Souza de Carvalho Adson Santos Martins

Background: Microscopy and enzyme-linked immunosorbent assay (ELISA) are routinely used for Cryptosporidium diagnosis, without differentiating the parasite species. Methods: Children’s feces were analyzed by modiﬁed Ziehl-Neelsen (mZN) and ELISA for Cryptosporidium diagnosis and by polymerase chain reaction-restriction fragment length polymorphism for species identification. Results: Cryptosporidium frequency was 2.6%. The sensitivity and specificity of ELISA were 85.7% and 99.7%, respectively, with excellent concordance with mZN (kappa=0.854). Parasite species were characterized as Cryptosporidium hominis (78.3%), Cryptosporidium felis (17.4%), and Cryptosporidium parvum (4.3%). Conclusions: Coproantigen ELISA is as efficient as mZN for Cryptosporidium diagnosis. Cryptosporidium genotyping suggests anthroponotic and zoonotic transmission to children.

Cryptosporidium parvum

Concordance

10.1590/0037-8682-0041-2022

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Citations (8)

Mecanismos fisiopatogênicos e diagnóstico laboratorial da infecção causada pela Entamoeba histolytica

Jornal Brasileiro de Patologia e Medicina Laboratorial (2008)

Fred Luciano Neves Santos Neci Matos Soares

A amebíase é a segunda causa de morte entre as doenças parasitárias no mundo. Seu agente etiológico é o protozoário Entamoeba histolytica, que através da secreção de proteinases é capazes de destruir o tecido hospedeiro, matando as células-alvo por contato e fagocitando eritrócitos. Dessa forma, os trofozoítos invadem a mucosa intestinal, provocando a colite amebiana. Em alguns casos atravessam a mucosa e, através da circulação porta, chegam ao fígado, onde causam necrose constituída por poucos trofozoítos rodeados de hepatócitos mortos e debris celulares liquefeitos. Essa invasão está diretamente relacionada com a capacidade de síntese e a secreção de moléculas responsáveis pela virulência dos trofozoítos, como os amebaporos, as lectinas e as cisteína proteinases. O diagnóstico da infecção causada pelo patógeno é rotineiramente realizado através da microscopia óptica de amostras frescas ou espécimes fixados. Entretanto essa metodologia apresenta limitações, sendo incapaz de distinguir as espécies pertencentes ao complexo E. histolytica/E. dispar. A pesquisa de coproantígenos e a reação em cadeia da polimerase (PCR) têm sido utilizadas para diferenciação desses protozoários em amostras fecais. No entanto, estudos mais aprofundados são necessários para maior compreensão sobre a relação parasita/hospedeiro, a proteômica e a genômica do protozoário, o desenvolvimento de vacinas e a real prevalência dessa infecção no Brasil e no mundo.

10.1590/s1676-24442008000400004

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Citations (14)

Avaliação da anemia e outros biomarcadores em pacientes alcoolistas

Revista de Ciências Médicas e Biológicas (2021)

Allan da Cruz Santos Joelma Nascimento de Souza Neci Matos Soares

Introdução: os transtornos por uso de álcool afetam milhões de pessoas em todo o mundo e podem comprometer vários órgãos e sistemas, em muitos casos devido à deficiência de micronutrientes. O objetivo deste artigo é avaliar a frequência e caracterizar a anemia e os biomarcadores metabólicos e hepáticos em pacientes alcoolistas. Metodologia: trata-se de um estudo transversal, no qual foram incluídos 65 pacientes alcoolistas, do sexo masculino, internados no Centro de Acolhimento e Tratamento de Alcoolistas, das Obras Sociais Irmã Dulce. Resultados: a maioria dos indivíduos avaliados apresentou contagem de hemácias, teor de hemoglobina e hematócrito abaixo dos valores de referência, com uma frequência de 61,5% (40/65) para todos os parâmetros e uma média de 4,1x106/uL, 13,0 g/dL e 38,6%, respectivamente. Entre os 40 indivíduos que apresentaram anemia, prevaleceu um padrão normocítico (25/40) e normocrômico (32/40) e uma frequência de anisocitose de 35,0% (14/40). Observou-se elevada frequência de indivíduos com altos níveis de AST e GGT, 64,6 (42/65) e 76,9% (50/61), respectivamente, enquanto apenas 13,8 (9/65) e 3,1% (2/63) apresentaram alterações na concentração plasmática de albumina e no tempo de protrombina, respectivamente. Conclusão: neste trabalho, foi possível observar uma elevada frequência de anemia normocítica e normocrômica, bem como altos níveis de AST e GGT, enquanto os biomarcadores da função hepática estavam dentro do valor de referência. Estes resultados contribuem para o entendimento da saúde do indivíduo alcoolista, podendo auxiliar na elaboração de medidas públicas que atuem na prevenção e promoção da saúde desses pacientes.

10.9771/cmbio.v20i3.47227

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Citations (0)

Recurrence of Strongyloides stercoralis infection in a patient with Hansen’s disease: A case report

Leprosy Review (2014)

Joelma Nascimento de Souza Paulo Roberto Lima Machado Márcia Cristina Aquino Teixeira Neci Matos Soares

In patients with immunosuppressive disorders, S. stercoralis infection may develop into a hyperinfection syndrome which, on rare occasions, may be a life-threatening condition. Therapy of S. stercoralis infection with thiabendazole has been limited, due to its numerous side effects, and has been replaced by albendazole and ivermectin. The present case report describes a case of Strongyloides Hyperinfection Syndrome (SHS) in a patient with Hansen’s disease and lack of response to first-line anthelmintic treatment. A 38 year-old man was diagnosed as having borderline lepromatous leprosy. He developed Erythema Nodosum Leprosum and was treated with thalidomide and prednisone. In May 2010 he was diagnosed with S. stercoralis infection and was treated with albendazole. One year later, the stool examination showed continued presence of S. stercoralis larvae. He was treated with ivermectin (6 mg) in a double dose (given 1 month apart) which resulted in larvae excretion clearance. The absence of infection was confirmed three times during a 1 year follow-up period by stool examination and non-detection of anti-S. stercoralis IgG levels.

Strongyloides stercoralis

Albendazole

Strongyloidiasis

10.47276/lr.85.1.58

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Citations (19)

Etiología infecciosa e indicadores de malabsorción o daño intestinal en diarrea infantil

Biomédica (2024)

Adson Santos Martins Samara Alves Santos Cláudia Alves da Silva Lisboa Tânia Fraga Barros Tereza Cristina Medrado Ribeiro

Introduction. The multifactorial etiology of gastroenteritis emphasizes the need for different laboratory methods to identify or exclude infectious agents and evaluate the severity of diarrheal disease.Objective. To diagnose the infectious etiology in diarrheic children and to evaluate some fecal markers associated with intestinal integrity.Materials and methods. The study group comprised 45 children with diarrheal disease, tested for enteropathogens and malabsorption markers, and 76 children whose feces were used for fat evaluation by the traditional and acid steatocrit tests.Results. We observed acute diarrhea in 80% of the children and persistent diarrhea in 20%. Of the diarrheic individuals analyzed, 40% were positive for enteropathogens, with rotavirus (13.3%) and Giardia duodenalis (11.1%) the most frequently diagnosed. Among the infected patients, occult blood was more evident in those carrying pathogenic bacteria (40%) and enteroviruses (40%), while steatorrhea was observed in infections by the protozoa G. duodenalis (35.7%). Children with diarrhea excreted significantly more lipids in feces than non-diarrheic children, as determined by the traditional (p<0.0003) and acid steatocrit (p<0.0001) methods. Moreover, the acid steatocrit method detected 16.7% more fecal fat than the traditional method.Conclusions. Childhood diarrhea can lead to increasingly severe nutrient deficiencies. Steatorrhea is the hallmark of malabsorption, and a stool test, such as the acid steatocrit, can be routinely used as a laboratory tool for the semi-quantitative evaluation of fat malabsorption in diarrheic children.

Steatorrhea

Etiology

10.7705/biomedica.6913

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Citations (2)

An improved anti-C3/IgG ELISA for quantification of soluble immune complexes

Journal of Immunological Methods (2001)

Neci Matos Soares Mittermayer B. Santiago Lain C. Pontes deCarvalho

Chromogenic

Immune complex

Rheumatoid factor

Antigen-Antibody Complex

10.1016/s0022-1759(00)00362-8

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Citations (13)

Asymptomatic Strongyloides stercoralis Hyperinfection in an Alcoholic Patient with Intense Anemia

Journal of Parasitology (2010)

Márcia Cristina Aquino Teixeira Elizabete J. Inês Flávia Thamiris Figueiredo Pacheco R. K. N. R. Silva Ana Verena Almeida Mendes

Strongyloides stercoralis infection is endemic in many tropical and subtropical areas. The parasite has the unusual ability to multiply inside the host due to the transformation of rhabditiform larvae into infective filariforms. Several studies have shown that chronic alcoholism is an important factor that predisposes to strongyloidiasis. The increased susceptibility to S. stercoralis infections seen in alcoholic individuals could be explained by their increased exposure to the parasite, malnutrition, breakdown of local immune responses, and/or alterations in intestinal barriers. Moreover, ethanol intoxication can elevate human endogenous corticosterone, which, in turn, suppresses T cell function and increases the fecundity and survival of the parasite, mimicking the effect of worm ecdysteroides. Although chronic alcoholism is a risk factor for nematode infection, most cases of hyperinfection or dissemination are associated with the presence of hepatic cirrhosis or strongyloidiasis-related symptoms. The present study describes a case of S. stercoralis hyperinfection in a 51-yr-old male patient without gastrointestinal or pulmonary symptoms and with previous anemia and chronic alcoholism. He was not receiving glucocorticoid therapy and tested negative for HTLV and human immunodeficiency virus (HIV), but he had a history of alcohol addiction for more than 20 yr. Laboratory test results showed increased eosinophilia and a high immunoglobulin E (IgE) level, which may have temporarily protected the patient from dissemination of infection, but not prevented proliferation of the parasite, as shown by the large number of S. stercoralis larvae recovered using the Baermann method. Evaluation for strongyloidiasis should occur in alcoholics, especially in endemic areas, to prevent occult asymptomatic infections from progressing to life-threatening cases.

Strongyloides stercoralis

Strongyloidiasis

Chronic infection

10.1645/ge-2358.1

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Citations (19)

HOOKWORM AND THREADWORM INFECTIONS AND THEIR ASSOCIATION WITH HEMOGLOBIN AND EOSINOPHIL CONCENTRATIONS IN RESIDENTS OF SALVADOR-BAHIA, BRAZIL

Revista do Instituto de Medicina Tropical de São Paulo (2013)

Fred Luciano Neves Santos Alina Maria Gonzaga Carlos de Souza Neci Matos Soares

SUMMARY Parasitic infections are responsible for substantial mortality and morbidity worldwide. In most healthy individuals, little overt pathology is observed during infection with S. stercoralis. However, the symptoms in advanced cases may include gastrointestinal bleeding. Anemia is most commonly associated with hookworm infection, especially when several hundred worms are present. Our study evaluates the relationship between the hookworm or S. stercoralis infection status and the hemoglobin concentration of individuals examined by a private network of laboratories in Salvador, Bahia, Brazil. We examined 374,120 samples from middle-class individuals living in Salvador City from January 2004 to April 2008. The stool samples were analyzed by the Lutz and Baermann-Moraes methods, and the blood samples were analyzed for hemoglobin concentration and eosinophil counting. The prevalence of hookworm and S. stercoralis were 0.27% (1,027) and 0.34% (1,286), respectively. The prevalence of hookworm and S. stercoralis infection was significantly higher in males than in females and increased with age. Eosinophilia was a common laboratorial finding in individuals infected with hookworm and S. stercoralis. The hemoglobin concentration was lower in the hookworm-infected individuals than in non-infected ones, but none of the examined patients were anemic. Lack of anemia could be a consequence of the socioeconomic status of these patients.

Strongyloides stercoralis

Hookworm Infections

Strongyloidiasis

10.1590/s0036-46652013000400003

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Citations (8)