Kenzo Fujimoto

Japan Advanced Institute of Science and Technology

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Shigetaka Nakamura

Japan Advanced Institute of Science and Technology

Yoshinaga Yoshimura

Japan Advanced Institute of Science and Technology

Takashi Sakamoto

Kumamoto University

Isao Saito

Fujita Health University

Takehiro Ami

Japan Advanced Institute of Science and Technology

Masayuki Ogino

Nihon University

Kazunobu Fujitaka

Fukuoka Institute of Health and Environmental Sciences

Shinzi Ogasawara

Shinshu University

Siro ABE

Japan Chemical Analysis Center

Siddhant Sethi

Japan Advanced Institute of Science and Technology

Cooperative Institutions

Japan Advanced Institute of Science and Technology

Kyoto University

The University of Tokyo

Osaka University

Japan Science and Technology Agency

Tohoku University

National Institutes for Quantum and Radiological Science and Technology

Nagoya University

Tokyo Institute of Technology

Kyushu University

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Site-specific transition of cytosine to uracil via reversible DNA photoligation

Chemical Communications (2006)

Kenzo Fujimoto Shigeo Matsuda Yoshinaga Yoshimura Takashi Matsumura Masayuki Hayashi

We report that deamination coupled with 5-carboxyvinyldeoxyuridine-mediated photobranching causes the heat-induced transition of cytosine to uracil with high efficiency without any side reaction.

Deamination

Cytosine

Uracil

10.1039/b605289d

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Citations (15)

Implication of health checkups for the JICA participants from developing countries.

SANGYO EISEIGAKU ZASSHI (1998)

Kenzo Fujimoto

10.1539/sangyoeisei.kj00001990387

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Citations (0)

Photocrosslinking of DNA using 4-methylpyranocarbazole nucleoside with thymine base selectivity

Organic & Biomolecular Chemistry (2021)

Junichi Mihara Kenzo Fujimoto

MEP K can selectively photocrosslink to thymine bases in a complementary nucleic acid strand.

Thymine

Cytosine

10.1039/d1ob01621k

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Citations (8)

Monotonically controlling right linear grammars with unknown behaviors to output a target string

Theoretical Computer Science (2019)

Nobuya Kimoto Ken Komiya Kenzo Fujimoto Satoshi Kobayashi

10.1016/j.tcs.2019.01.009

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Citations (2)

Present Status of Natural Radiation Research

Journal of Radiation Research (1997)

Kenzo Fujimoto

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A Novel Method to Synthesize Versatile Multiple‐Branched DNA (MB‐DNA) by Reversible Photochemical Ligation

ChemBioChem (2005)

Shinzi Ogasawara Kenzo Fujimoto

Branching out into the nano world. We have demonstrated that DNA containing 5-carboxyvinyldeoxyuridine (CVU) at midstream can be used to synthesize multiple-branched DNA with high efficiency by irradiation at 366 nm (see scheme). This novel method is well suited to DNA nanodevices such as the DNA walker, DNA computer, and DNA architecture, as well as to signal amplification. Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2268/2005/z500188_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.

DNA Computing

Midstream

10.1002/cbic.200500188

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Citations (32)

2P-121 可逆的DNA光ライゲーションを用いたDNAコンピューティング(核酸・相互作用,複合体,第46回日本生物物理学会年会)

生物物理 (2008)

Takehiro Ami Shinji Ogasawara Hiroshi Matsumura Hajime Okada Kenzo Fujimoto

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Study of Photochemical Cytosine to Uracil Transition via Ultrafast Photo-Cross-Linking Using Vinylcarbazole Derivatives in Duplex DNA

Molecules (2018)

Siddhant Sethi Shigetaka Nakamura Kenzo Fujimoto

Gene therapies, including genome editing, RNAi, anti-sense technology and chemical DNA editing are becoming major methods for the treatment of genetic disorders. Techniques like CRISPR-Cas9, zinc finger nuclease (ZFN) and transcription activator-like effector-based nuclease (TALEN) are a few such enzymatic techniques. Most enzymatic genome editing techniques have their disadvantages. Thus, non-enzymatic and non-invasive technologies for nucleic acid editing has been reported in this study which might possess some advantages over the older methods of DNA manipulation. 3-cyanovinyl carbazole (CNVK) based nucleic acid editing takes advantage of photo-cross-linking between a target pyrimidine and the CNVK to afford deamination of cytosine and convert it to uracil. This method previously required the use of high temperatures but, in this study, it has been optimized to take place at physiological conditions. Different counter bases (inosine, guanine and cytosine) complementary to the target cytosine were used, along with derivatives of CNVK (NH2VK and OHVK) to afford the deamination at physiological conditions.

Deamination

Cytosine

Uracil

Nuclease

Cytosine deaminase

10.3390/molecules23040828

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Citations (7)

Specific and reversible photochemical labeling of plasmid DNA using photoresponsive oligonucleotides containing 3-cyanovinylcarbazole

Molecular BioSystems (2011)

Kenzo Fujimoto Kaoru Hiratsuka-Konishi Takashi Sakamoto Tomoko Ohtake Ken‐ichi Shinohara

To develop a covalent and specific labeling method for single- and double-stranded plasmid DNA, photoresponsive oligonucleotide containing 3-cyanovinylcarbazole nucleoside was adopted. Single- and double-stranded plasmid DNA was successfully labeled/de-labeled with Cy3 and/or biotin by photoirradiation.

Double stranded

10.1039/c2mb05422a

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Citations (16)

Ein nicht verdrilltes Tetrakis(organosilyl)ethen

Angewandte Chemie (1993)

Masahiro Murakami Michinori Suginome Kenzo Fujimoto Yoshihiko Ito

Durch Bissilylierung unter hohem Druck konnte das Ethenderivat 1 , das entlang der CC‐Bindung nicht verdrillt ist, synthetisiert werden. Die UV‐Spektren und die Struktur von 1 im Kristall deuten darauf hin, daß die schwache Absorption bei 361 nm in erster Linie der vierfachen Si‐Substitution und nicht, wie bisher bei Tetrakis(organosi‐lyl)ethenen vermutet, der Verdrillung zuzuschreiben ist. magnified image

10.1002/ange.19931051041

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Citations (8)