SŠ

Sandra Šipetić

University of Belgrade

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Hristina Vlajinac

University of Belgrade

Jelena Marinković

University of Belgrade

Milan Bjekić

Institut za kardiovaskularne bolesti Dedinje

Jadranka Maksimović

University of Belgrade

VŽ

Vladan Živaljević

University of Belgrade

Aleksandra Nikolić

Clinical Centre of Kragujevac

Isidora S Vujcic

University of Belgrade

Milena Ilić

University of Kragujevac

Isidora Ratkov

University of Belgrade

Ivan Paunović

University of Belgrade

Cooperative Institutions

University of Belgrade

260

Univerzitetski Klinički Centar Srbije

105

Centar za Promociju Nauke

Institut za Reumatologiju

Institute of Public Health of Serbia

University of Belgrade – Faculty of Medicine

Center for Health, Exercise and Sport Sciences

Military Medical Academy

University of Kragujevac

University of Novi Sad

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Detection of laboratory biomarkes in haematological and pulmonology patients at high risk for aspergillosis

Srpski arhiv za celokupno lekarstvo (2012)

Eleonora Ratkov Ana Vidović Predrag Minić Dragana Janić Sandra Šipetić

Introduction. During the past decades a dramatic increase in the incidence of invasive fungal diseases, especially invasive aspergillosis has been observed. Undiagnosed and diagnosed late invasive aspergillosis is followed by lethality of up to 90%. Detection of early laboratory biomarkers (galactomannan and anti-Aspergillus antibodies) contributes to early diagnosis and is used for screening, as well as for monitoring therapy of aspergillosis. Objective. The aim was to evaluate usefulness of ?non-culture? methods (galactomannan and anti-Aspergillus antibodies IgA, IgM and IgG) for early diagnosis of aspergillosis in high-risk patients. Methods. Prospective two-year study involved 262 high-risk patients for aspergillosis. In pulmonology and haematology patients (adults and children) blood samples were tested on galactomannan and anti-Aspergillus antibodies. Results. Early laboratory biomarkers were statistically significantly higher in pulmonology patients (p=0.00033). However, in haematological patients galactomannan was a more frequently positive finding, while in pulmonology patients it was the finding of anti-Aspergillus antibodies. It is interesting that, despite the possible immunosuppression, in about 1/3 of haematological patients anti-Aspergillus antibodies were confirmed. Conclusion. Early diagnosis and treatment of aspergillosis represent both clinical and laboratory problem. Nowadays, the application of new ?non-culture? methods is of particular importance for the outcome of aspergillosis. Clinical features, laboratory findings of biomarkers and their correct interpretation significantly increase the possibility of timely implementation of appropriate therapy. In this regard, the new organization of reference laboratory for medical mycology has significantly improved the outcome of aspergillosis in high-risk patients in our country. However, further investigations, implementation of European standards and introduction of new diagnostic methods are necessary in this field.

Galactomannan

Pulmonology

Hematology

Medical microbiology

Immunosuppression

10.2298/sarh1206290r

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Citations (1)

Preoperative Anxiety is Associated With Postoperative Complications in Vascular Surgery: A Cross‐Sectional Study

World Journal of Surgery (2022)

Ksenija Jovanović Nevena Kalezić Sandra Šipetić Vladan Živaljević Milan Jovanović

Vascular surgery

Cross-sectional study

Cardiothoracic surgery

10.1007/s00268-022-06575-0

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Citations (9)

Prevalence of spondyloarthritis and its subtypes - are they really comparable?

Srpski arhiv za celokupno lekarstvo (2019)

Mirjana Zlatković‐Švenda R Stojanović Sandra Šipetić Marija Radak-Perović Françis Guillemin

Introduction/Objective. Increasing spondyloarthritis (SpA) prevalence in the last several decades cannot be attributed to disease manifestations alone. The objective of this paper is to review the prevalence of SpA and its subtypes: ankylosing spondylitis (AS), psoriatic arthritis (PsA), reactive arthritis (ReA), SpA related to inflammatory bowel disease (IBD) and undifferentiated SpA (UnSpA). Methods. MEDLINE literature search was done via PubMed, Google Scholar, and Embase databases, using terms for spondyloarthritis, and prevalence, with an additional hand searching. Results. As compared with southern European countries, northern European countries (Scotland, Sweden, France) showed lower SpA prevalence rates (0.21?0.45% vs. 1.06% and 1.35% in Italy and Turkey, respectively). The lowest world SpA prevalence was in African and Southeast Asian countries (0?0.19%), and the highest was in Alaska (2.5%). The widest variability in PsA prevalence was in Europe (northern 0.02?0.19%, southern 0.42%). The lowest world PsA prevalence was in Japan (0.001%), followed by China (0.01?0.10%). The European ReA prevalence ranged from 0.04% in Greece to 0.10% in Serbia and Germany, and the European UnSpA prevalence varied from 0.02% in Serbia to 0.67% in Germany; the highest world UnSpA prevalence was in Lebanon (3.4%). Studies aimed at estimating the SpA prevalence differed in sampling strategy and confirmation criteria, different cutoffs for age groups inclusion, presentation of standardized or row results, etc. Conclusion. Variation in the SpA prevalence cannot be attributed to genetic or geographic distribution only. Differences in methodology of studies add to the diversification, described more in-depth in this review.

Prevalence

Reactive arthritis

10.2298/sarh180110009z

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Prevalence of macrolide resistance in Streptococcus pyogenes collected in Serbia.

PubMed (2010)

Ljiljana Pavlović Edita Grego Sandra Šipetić

The purpose of our study was to determine the prevalence of macrolide resistance in 3,188 pharyngeal Streptococcus pyogenes isolates collected at the Institute of Public Health of Serbia during the period 2006-2008. The disk diffusion tests were used to determine the susceptibility of the isolates. Two hundred and sixteen S. pyogenes isolates (6.8%) were resistant to erythromycin, with 9 isolates coresistant to tetracycline: 181 isolates harbored mefA gene, 19 ermB gene, 11 ermA(TR) gene, 5 ermB and mefA genes, and 7 tetM gene. Although the prevalence of macrolide resistance in pharyngeal S. pyogenes isolates is low in Serbia, monitoring of the emergence of resistance is advisable.

Streptococcus Pyogenes

Macrolide Antibiotics

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Prevalence of spondyloarthritis in Serbia: a EULAR endorsed study

Annals of the Rheumatic Diseases (2015)

Mirjana Zlatković‐Švenda R Stojanović Sandra Šipetić Marija Radak-Perović Nemanja Damjanov

In order to determine the burden of inflammatory rheumatic diseases across Europe, the European League Against Rheumatism (EULAR) unique-methodology prevalence survey of rheumatoid arthritis (RA) and spondyloarthritis (SpA) was carried out in several European countries, including Serbia. Aiming to enable comparable results, it comprised a common two-stage approach: a detection phase (validated screening telephone questionnaire, primarily tested in France1 ,2) and a confirmation phase (according to a certified rheumatologist or, for previously non-diagnosed cases, a rheumatology examination). The Serbian SpA prevalence survey was conducted by 30 trained interviewers on urban population in four Serbian towns: Belgrade (north), and Cacak, Krusevac and Užice (south), by telephone (every 100th telephone number) from April to October 2008. The sample covered 36.5% of the total Serbian population with more than 99% Caucasians, mostly orthodox Serbs (83%), <4% Hungarians, Gypsies and Bosnians and a minority of other nationalities. Respondents were asked whether they have (or …

Serbian

Rheumatism

10.1136/annrheumdis-2015-207359

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Citations (8)

Does Penis Size Influence Sexual Behaviour of Men who Have Sex with Men?

Acta Facultatis Medicae Naissensis (2018)

Milan Bjekić Sandra Šipetić Hristina Vlajinac Ivana Dunić

Abstract Penis size is a major body image concern for the majority of men in western nations, while in gay culture the penis has become a body part linked to sexual attractiveness and viability. The aim of this study was to reveal influence of the perceived penis size on sexual behaviour, condom use, sexually transmitted infections and men’s sexual positioning among men who have sex with men. In this cross-sectional study, the data were collected from consecutive men who have sex with men who attended Counselling for Sexually Transmitted Diseases at the City Institute for Skin and Venereal Diseases in Belgrade, Serbia. Out of 319 participants, 6.6% perceived their penis as "below average", 71.5% as "average", and 21.9% as "above average". In comparison with men with an average penis, men with below average penis were more frequently unsatisfied with their penis size (p < 0.05), more frequently lied to others about their penis size (p < 0.001) and took more frequently the passive sexual role (p < 0.05). Men with above average penis were more frequently satisfied with their penis size (p < 0.001), took more frequently the active sexual role (p < 0.01), they had more sexual partners (p < 0.05), more problems with a tight condom (p < 0.001) and more gonorrhoea/Chlamydia infections (p < 0.001) than men with an average penis. Perception of one’s penis size was associated with some aspects of sexual behaviour and the frequency of sexually transmitted diseases.

10.2478/afmnai-2018-0033

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Citations (1)

Birth order and childhood type 1 diabetes risk: a pooled analysis of 31 observational studies

International Journal of Epidemiology (2010)

Chris R. Cardwell Lars C. Stene Geir Joner Max Bulsara Ondřej Cinek

Background The incidence rates of childhood onset type 1 diabetes are almost universally increasing across the globe but the aetiology of the disease remains largely unknown. We investigated whether birth order is associated with the risk of childhood diabetes by performing a pooled analysis of previous studies. Methods Relevant studies published before January 2010 were identified from MEDLINE, Web of Science and EMBASE. Authors of studies provided individual patient data or conducted pre-specified analyses. Meta-analysis techniques were used to derive combined odds ratios (ORs), before and after adjustment for confounders, and investigate heterogeneity. Results Data were available for 6 cohort and 25 case–control studies, including 11 955 cases of type 1 diabetes. Overall, there was no evidence of an association prior to adjustment for confounders. After adjustment for maternal age at birth and other confounders, a reduction in the risk of diabetes in second- or later born children became apparent [fully adjusted OR = 0.90 95% confidence interval (CI) 0.83–0.98; P = 0.02] but this association varied markedly between studies (I2 = 67%). An a priori subgroup analysis showed that the association was stronger and more consistent in children <5 years of age (n = 25 studies, maternal age adjusted OR = 0.84 95% CI 0.75, 0.93; I2 = 23%). Conclusion Although the association varied between studies, there was some evidence of a lower risk of childhood onset type 1 diabetes with increasing birth order, particularly in children aged <5 years. This finding could reflect increased exposure to infections in early life in later born children.

Etiology

10.1093/ije/dyq207

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Citations (57)

Patients’ Fears and Perceptions Associated with Anesthesia

Medicina (2022)

Ksenija Jovanović Nevena Kalezić Sandra Šipetić Vladan Živaljević Milan Jovanović

Background and Objectives: It has been suggested that intense feelings of fear/anxiety and significant patient concerns may affect the perioperative course. Those findings emphasize the importance of surgical patients' preoperative feelings. Still, current knowledge in this area is based on a limited number of studies. Thus, we think that there is a need to further explore patients' preoperative fears, better characterize risk factors and reasons for their occurrence, and evaluate patients' perspectives associated with anesthesia. Materials and Methods: A total of 385 patients undergoing vascular surgery were preoperatively interviewed using a questionnaire that included demographics and questions related to patients' fears and perceptions of anesthesia. Statistical analyses included descriptive statistics, Pearson's χ2 and McNemar tests, and multivariate ordinal logistic regression. Results: The main causes of patients' preoperative fear were surgery (53.2%), potential complications (46.5%), and anesthesia (40%). Female sex was a predictor of surgery and anesthesia-related fear (OR = 3.07, p = 0.001; OR = 2.4, p = 0.001, respectively). Previous experience lowered the fear of current surgery (OR = 0.65, p = 0.031) and anesthesia (OR = 0.6, p = 0.017). Type of surgery, type of anesthesia, educational and socioeconomic status, and personal knowledge of an anesthesiologist affected specific anesthesia-related fears. Over 25% of patients did not know that an anesthesiologist is a physician, and only 17.7% knew where anesthesiologists work. Level of education and place of residence influenced patients' perceptions of anesthesia. Conclusions: Anesthesia-related fears are affected by the type of surgery/anesthesia, experience with previous surgery, and personal knowledge of an anesthesiologist. Women, patients with lower education levels, and patients with poorer socioeconomic status are at higher risk of developing those fears. The perception of anesthesiologists is inadequate, and knowledge of anesthesia is poor. Promotion of patient education regarding anesthesia is needed to alleviate those fears and increase understanding of anesthesia.

McNemar's test

Affect

10.3390/medicina58111577

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Citations (11)

Prevalence and risk factors of Chlamydia trachomatis genital infection among military personnel of the Armed Forces of Serbia: A cross-sectional study

Vojnosanitetski pregled (2017)

Željko Jadranin Elizabeta Ristanović Sonja Atanasievska Gordana Dedić Sandra Šipetić

Background/Aim. Chlamydia trachomatis infection (CTI) is an increasing public health problem worldwide and is the most frequent sexually transmitted infection. Studies conducted in many armed forces worldwide showed that CTI is common within military population and generate significant healthcare costs. The aim of this study was to estimate the prevalence of CTI among members of the Serbian Armed Forces (SAF) and to determine risk factors for this infection. Methods. The study was designed as a cross-sectional survey and consisted of completing a questionnaire and chlamydial testing. The questionnaire was divided into two question groups: one was about demographic/service related characteristics and the other was about behavioral patterns/ habits. Chlamydia trachomatis real time polymerase chain reaction (Real-TM PCR) was used for detection of pathogen genome specific sequence in the male urethral swabs and in the female endocervical swabs. All data collected were used to compare military personnel with and without CTI. Risk factors independently associated with CTI were identified by the stepwise multivariate logistic regression analysis (MLRA) of variables selected by the univariate logistic regression analysis (ULRA), with a limit for entering and removing variables from the model at 0.05. Results. The overall prevalence of CTI was 55 of 356 respondents (15.4%; 95% CI 0.5?2.7%). The ULRA identified that CTI was significantly associated with several characteristics: number of sexual partners during previous year (p = 0.008), knowledge about symptoms of CTI (p = 0.035), tattooing (p = 0.035) and married or in stable relationship (p = 0.022). The MLRA revealed that number of different sexual partners during last year was independent risk factor of CTI (p = 0.026; OR : 0.344; 95% CI: 0.13?0.88). Conclusion. CTI is significant problem in male and female military personnel in the SAF. The number of different sexual partners during previous year was independently associated with CTI. These finding indicates that screening for CTI should be undertaken in the SAF, to reduce rates of CTI in the SAF and to prevent morbidity due to this infection.

Cross-sectional study

Univariate analysis

Military medicine

10.2298/vsp170424088j

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Citations (1)

Determination of presence of resistance to erythromycin and tetracycline antibiotics in isolated streptococcus species from group C and group G

Acta veterinaria (2010)

Ljiljana Pavlović Edita Grego Sandra Šipetić Jadranka Žutić Jelena Ašanin

The purpose of this study was to determine the presence of resistance to macrolide and tetracycline in β-haemolytic streptococci which belong to group C (GCS) and group G (GGS), isolated from variuos clinical specimens collected at the Institute of Public Health of Serbia during the period 2006-2008. After determination of resistance in isolated streptococci to tested antibiotics, their phenotypic and genotypic characteristics were investigated. Resistance to erythromycin and tetracycline were evaluated in a total of 112 GGS and 29 GCS isolates. Resistance to erythromycin was determined in 6 (6.9%) GGS isolates and 4 of them were also resistant to tetracycline. Resistance to erythromycin was determined in 2 (5.4%) GCS isolates, but both isolates were sensitive to tetracycline. The erythromycinresistance phenotypes were determined by the double-disk test with erythromycin and clindamycin disks. All 8 isolates showed the MLSB macrolide resistance phenotype leading to macrolide, lincosamide and streptogramin B resistance. These 8 isolates were genotyped for the presence of the erm(TR), erm(B), mef(A) and tet(M) genes and transposon of the Tn916-Tn1545 family by polymerase chain reaction. The presence of erm(TR) gene was detected in 3 GGS isolates and in both GCS isolates, while the presence of erm(B) gene was detected in other 3 GGS isolates. The presence of tet(M) gene with transposon of the Tn916-Tn1545 family was detected in all 4 tetracycline-resistant GGS isolates. The results of this study indicate that continued monitoring of macrolide- and tetracycline- resistance in tested groups of streptococci in Belgrade and in Republic of Serbia is necessary.

10.2298/avb1006487p

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Citations (2)