Suhaib Ahmed

Imperial College Healthcare NHS Trust

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Parvez Ahmed

Shahid Beheshti University of Medical Sciences

Shahid Raza

RISE Research Institutes of Sweden

Tariq Mehmood Satti

National University of Medical Sciences

Adeel Arif

NED University of Engineering and Technology

Syed Kamran Mehmood

National University of Medical Sciences

Azhar Mubarik

Army Medical College

Qamar-Un-Nisa Chaudhry

National Institute Of Blood Disease and Bone Marrow Transplantation

Khalil Ullah

Abdul Wali Khan University Mardan

Anna Sureda

Duran i Reynals Hospital

Mahmoud Aljurf

King Faisal Specialist Hospital & Research Centre

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Armed Forces Institute of Pathology

Army Medical College

National University of Medical Sciences

Combined Military Hospital

Rawalpindi Medical University

Shifa International Hospital

Dow University of Health Sciences

National Institute Of Blood Disease and Bone Marrow Transplantation

Liaquat National Hospital

Shahid Beheshti University of Medical Sciences

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Relapsed diffuse large B-cell lymphoma treated by reduced-intensity allogeneic stem cell transplantation with donor lymphocyte infusion.

PubMed (2010)

Qamar-Un-Nisa Chaudhry Parvez Ahmed Khalil Ullah Tariq Mehmood Satti Shahid Raza

A 42 years old male with relapsed diffuse large B-cell lymphoma was given second-line chemotherapy followed by reduced intensity allogeneic stem cell transplantation from HLA matched brother. Twelve weeks posttransplant, his disease relapsed evidenced by the appearance of lymphoma cells in the peripheral blood and declining donor chimerism. Donor lymphocyte infusion was given that induced complete lymphoma remission. The patient is well 3 years posttransplant with his disease in complete remission.

Donor lymphocyte infusion

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The role of hematopoietic SCT in adult Burkitt lymphoma

Bone Marrow Transplantation (2012)

Suhaib Ahmed Anna Sureda Mahmoud Aljurf

Chemoimmunotherapy

Minimal Residual Disease

10.1038/bmt.2012.129

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Frequency of bcl-2 gene rearrangement in B-cell Non-Hodgkin's lymphoma.

PubMed (2009)

Adeel Arif Shahid Jamal Sajid Mushtaq Suhaib Ahmed Azhar Mubarik

The objective of the study was to determine the frequency of bcl-2 gene rearrangement in B-cell Non-Hodgkin's lymphoma (NHL) and identify different breakpoints of bcl-2 gene.Thirty cases of B-cell lymphoma (including 8 cases of follicular lymphoma, 19 cases of diffuse large B-cell lymphoma and 3 cases of T-cell rich B-cell lymphoma) were included in the study. Good quality of DNA was extracted in 4 cases from formalin fixed paraffin embedded tissue and in 26 cases from fine needle aspirate. The polymerase chain reaction was done for major break point region (mbr), minor cluster region (mcr) and intermediate cluster region (icr) of the bcl-2 gene.The bcl-2 gene rearrangement was identified in 23.3% of B-cell lymphoma, 50% of follicular lymphoma, 15% of diffuse large B-cell lymphoma and no bcl-2 rearrangement was identified in any of the T-cell rich B-cell lymphomas. Further analysis showed the icr breakpoint in 16.7% of B-cell lymphoma, 37.5% of follicular lymphoma and 10.5% of diffuse large B-cell lymphoma. Involvement of the mbr breakpoint was found in 6.7% of B-cell lymphoma, 12.5% of follicular lymphoma, and 5.3% of diffuse large B-cell lymphoma. Involvement of the mcr breakpoint was not seen in any of the cases.The bcl-2 gene rearrangement is quite frequent in follicular lymphoma, followed by diffuse large B-cell lymphoma. The commonest breakpoint in present series is icr followed by mbr. This indicates that primers for bcl-2 gene must include icr primer, whenever the bcl-2 gene is being evaluated for B-cell NHL in this part of the world and this might reduce the variability of frequency of bcl-2 gene rearrangement within and between different regions.

Follicular lymphoma

Gene rearrangement

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B-cell lymphoma

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