Xiu Sun

Beijing Ditan Hospital

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Jin Da Wang

Beijing Tongren Hospital

Ying Xiong

Beijing Tongren Hospital

Jing Shang Zhang

Beijing Tongren Hospital

Mayinuer Yusufu

University of Melbourne

Xiu Hua Wan

Beijing Tongren Hospital

Jing Li

Chinese Academy of Medical Sciences & Peking Union Medical College

Huichun Xing

Beijing Ditan Hospital

Shu Ying Chen

Chinese University of Hong Kong

Xin Chi

Beijing Ditan Hospital

Shunai Liu

Beijing Ditan Hospital

Cooperative Institutions

Capital Medical University

Beijing Tongren Hospital

Beijing Institute of Neurosurgery

Beijing Ditan Hospital

Institute of Ophthalmology

Peking University

Tongren Hospital

Beijing YouAn Hospital

Chinese Academy of Medical Sciences & Peking Union Medical College

Beijing Chao-Yang Hospital

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The effect of retaining intact posterior capsule in congenital cataract surgery in children aged 4–8 years

BMC Ophthalmology (2021)

Jing Shang Zhang Jin Da Wang Mayinuer Yusufu Kai Cao Shan Jin

Abstract Background The present study sought to observe the effect of retaining intact posterior capsule in congenital cataract surgery in children aged 4–8 years. Methods This is a retrospective case control study. Seventy-seven children (130 eyes) aged from 4 to 8 years who underwent cataract surgery were divided into two groups. In Group A, 50 eyes underwent phacoemulsification, intraocular lens implantation and posterior capsule capsulotomy combined with anterior vitrectomy. In Group B, 80 eyes underwent cataract phacoemulsification and intraocular lens implantation. The postoperative visual acuity and the rate of complications were compared. Results In all patients, cataract surgeries were performed evenly without intraoperative complications. The follow-up time ranged from 6 months to 42 months. No apparent visual axis opacity was detected in group A during the follow-up. By the last visit, apparent visual axis opacity was detected in 31 eyes (38.75%) in group B. Among them, 9 eyes (29.03%) with mild posterior capsule opacification (PCO) were treated with Nd:YAG laser, 3 eyes (9.68%) with thick proliferative membranes were treated with posterior capsule capsulotomy combined with anterior vitrectomy and proliferative membranes in 19 eyes (61.29%) were completely aspired and the posterior capsule was retained. During follow-up, only 2 (6.45%) eyes had PCO recurrence and were treated with Nd:YAG laser. The visual acuity was significantly higher than that before surgery in all patients. Conclusions For older children, the incidence of PCO will be low even if intact posterior capsule is retained. Either Nd:YAG laser or surgical treatment for PCO will be able to maintain good vision.

Posterior Capsulotomy

Capsule

Posterior Capsule Opacification

10.1186/s12886-021-02098-9

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Citations (7)

Anterior Chamber Depth and Chamber Angle and Their Associations With Ocular and General Parameters. The Beijing Eye Study

Investigative Ophthalmology & Visual Science (2008)

Ke Ma Liang Xu Weijie Cao Y. Wang C. Chen

Anterior chamber angle

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Characteristics and Clinical Significance of Intestinal Microbiota in Patients with Chronic Hepatitis B Cirrhosis and Type 2 Diabetes Mellitus

Journal of Diabetes Research (2022)

Xiu Sun Xin Chi Yingying Zhao Shunai Liu Huichun Xing

Background. Chronic hepatitis B cirrhosis is often accompanied by glucose metabolism disorder, and intestinal microbiota was closely related to both cirrhosis and diabetes. There are few studies on the role of intestinal microbiota in hepatitis B liver cirrhosis and diabetes mellitus (LCDM). The purpose of this study was to investigate the characteristics of intestinal microbiota in patients with LCDM and to evaluate the relationship between the severity of intestinal microbiota imbalance and clinical significance. Methods. A case-controlled study was conducted. People who met the inclusion and exclusion criteria of chronic HBV-related liver cirrhosis (LC), LCDM, and healthy controls (HC) were enrolled in, and their fecal and blood samples were collected. The V3-V4 region of 16s rDNA gene of fecal microbiota was sequenced; the bioinformatics analysis including α-diversity, β-diversity, and linear discriminant analysis (LDA) effect size (LEfSe) was performed; and the correlation between bacteria and clinical indexes was analyzed. Results. A total of 70 participants completed fecal and blood tests, including 20 HC, 20 LCDM, and 30 LC. The α diversity of intestinal microbiota in the LCDM decreased than that in the HC. The abundance of Proteobacteria, Streptococcus, Escherichia-Shigella, and Lactobacillus increased, while the abundance of Bacteroidota, Bacteroides, Prevotella, Faecalibacterium, and Lachnospira decreased in the LCDM compared with the HC. The abundance of Lactobacillus, Roseburia, and Veillonella and the degree of hepatitis B cirrhosis dysbiosis indicator (HBCDI) increased in the LCDM than in the LC. The abundance of Escherichia-Shigella, Veillonella, and Lactobacillus positively correlated with liver injury and fasting blood glucose (FBG) level. The abundance of Escherichia-Shigella, Veillonella, Streptococcus, and Lactobacillus increased more significantly when FBG and glycosylated hemoglobin level increased. Conclusion. Intestinal microbiota of patients with LCDM was significantly disordered, and the degree was more serious than that cirrhosis patients without diabetes.

Clinical Significance

10.1155/2022/1826181

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Effect of Lens Capsular Tension Ring on Preventing Capsular Contraction Syndrome in the Surgery of Retinitis Pigmentosa Combined with Cataract: Retrospective Case Series

Authorea (Authorea) (2020)

Chang Xi Chen Jin Da Wang Jing Shang Zhang Ying Xiong Jing Li

PURPOSE: To observe the effect of phacoemulsification and intraocular lens (IOL) implantation with or without lens capsular tension ring (CTR) on retinitis pigmentosa (RP) combined with cataract patients. DESIGN: Retrospective cases series study. METHODS: 63cases (84 eyes) of RP with cataract were collected including 30 males and 33 females. Phacoemulsification with 3.0mm clear corneal incision was performed in all the patients. IOL+CTR implantation was performed in 44 eyes, and only IOL implantation was performed in 40 eyes. All cases were followed up at 1 week and 1, 3, 6 months after the surgery to compare the best corrected visual acuity (BCVA), intraocular pressure (IOP), corneal endothelial cell count and complications before and after the surgery. RESULTS: all surgery were successfully completed by the same physician, and IOL and CTR were all implanted in capsule without complications. The BCVA at 6 months after surgery was 0.91±0.88 LogMAR. It improved a little compared with the BCVA(1.3±0.7LogMAR) before surgery and there was a signifcant difference in statistic(P=0.003). Four cases of capsule contraction syndrome(CCS) occurred in no CTR implantation group and there was no CCS in CTR group. There was signifcant difference in statistic about the incidence of CCS between two groups(P=0.047). CONCLUSIONS: Phacoemulsification for RP combined with cataract is safe and reliable, and CTR implantation is helpful to reduce the complications caused by capsule contraction.

10.22541/au.159284900.06066124

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Screening for hepatitis B virus and tuberculosis infection in patients with moderate‐to‐severe psoriasis recruiting for biological therapy in China

British Journal of Dermatology (2019)

Xiu Sun Linfeng Li

10.1111/bjd.17693

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Prevalence of hepatitis C virus and hepatitis B virus infections in HIV-positive Chinese patients

Epidemiology and Infection (2010)

Yi Yan Yujuan Gao Xiu Sun Wei Wang Xiaojie Huang

To evaluate the prevalence of hepatitis C virus (HCV) and/or hepatitis B virus (HBV) infections in HIV-infected patients in China, an epidemiological serosurvey was conducted from May 2007 to September 2008 using a random cluster sampling design of infectious disease hospitals in seven high HIV-prevalent provinces (municipalities). Univariate analysis and logistic regression were used to study the determinants of HIV and HBV and/or HCV co-infection. The overall prevalence was 41·83% (95% CI 40·36-43·30) for anti-HCV and 12·49% (95% CI 11·50-13·48) for HBsAg, respectively. The prevalence of anti-HCV and HBsAg varied according to the route of HIV transmission. Compared to those with sexually acquired HIV infection, intravenous drug users and blood donors/recipients had the greatest risk of carrying anti-HCV. Needle sharing and unprotected sexual exposures are important modes of transmission for HBV. Further interventions including health education and harm reduction strategies should be implemented in high-risk populations.

harm reduction

Hepatitis B

Sexual transmission

Hepatitis C

10.1017/s0950268810001597

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Citations (32)

Efficacy of Biejiajian Pill on Intestinal Microbiota in Patients with Hepatitis B Cirrhosis/Liver Fibrosis: A Randomized Double-Blind Controlled Trial

Chinese Journal of Integrative Medicine (2023)

Xin Chi Danying Cheng Xiu Sun Shunai Liu Rongbing Wang

Pill

Hepatitis B

10.1007/s11655-023-3542-2

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Effect of lens capsular tension ring on preventing capsular contraction syndrome in the surgery of retinitis pigmentosa combined with cataract: Retrospective case series

International Journal of Clinical Practice (2021)

Chang Xi Chen Jin Da Wang Jing Shang Zhang Ying Xiong Jing Li

Capsule

10.1111/ijcp.14272

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Citations (7)

Comments on: Risk of dyslipidemia in chronic hepatitis B patients taking tenofovir alafenamide: a systematic review and meta-analysis

Hepatology International (2024)

Yan Wang Xiu Sun Junyan Zhang Qi Mei

Tenofovir alafenamide

Dyslipidemia

Tenofovir

10.1007/s12072-024-10642-0

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Clinical characteristics and survival analysis of patients with hepatocellular carcinoma after hepatitis B virus turning negative

Advances in Clinical and Experimental Medicine (2022)

Hong Li Wenmin Guo Xie Qian Xiu Sun Qiong Wang

Hepatitis B virus (HBV) infection is one of the most common infections, affecting 248 million people worldwide. Hepatitis B virus can progress to cirrhosis, liver failure and hepatocellular carcinoma (HCC).To analyze the clinical characteristics and survival time of HCC occurrence in patients with HBV infection after virus turning negative.The Kaplan-Meier and log rank survival analysis were performed to compare the overall survival (OS) of the patients with HCC in different groups.The 1-, 3- and 5-year OS rates of the 104 investigated patients were 76.4%, 54.4% and 20.5%, respectively. The median survival time was 37 months. The median survival time of HBV-DNA-negative group was longer than that of the HBV-DNA-positive group (negative compared to positive: 42 compared to 36, p = 0.003). The 5-year OS rate of patients receiving antiviral therapy before HCC diagnosis in the HBV-DNA-negative group was higher than that in the HBV-DNA-positive group (negative compared to positive: 53.0% compared to 0%, p = 0.022). There was no significant difference in the 5-year OS rate in patients who did not receive antiviral therapy before HCC diagnosis between HBV-DNA-negative and HBV-DNA-positive groups (p = 0.195).Among HBV-infected patients, a significant proportion of virus-negative patients develop liver cancer and require long-term continuous monitoring. A long-term effective antiviral therapy can improve the survival rate of patients with liver cancer. This study revealed important clinical characteristics of HCC patients and provided useful information for their clinical management and monitoring.

Liver Cancer

Hepatitis B

10.17219/acem/146859

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Citations (1)