Flexible all-plastic multijunction solar cells with high photovoltage have been demonstrated via optimization of the charge-recombination layer and shown to power portable electronics.
We demonstrated a repetition-rate-tunable self-mode-locked optically pumped semiconductor disk laser (OP-SDL). The highest repetition rate of mode-locked pulses was 6.13 GHz. When using an output mirror with a radius of curvature of 300 mm, the tuning range was from 0.6 GHz to 4.35 GHz. When replaced by an output mirror with a radius of curvature of 50 mm, the tuning range was from 3.13 GHz to 6.13 GHz. The entire tuning process was continuous, and OP-SDL was always in a stable mode-locked working state. To the best of our knowledge, this is the first work to obtain repetition rate of 6.13 GHz and tunable laser in self-mode-locked OP-SDLs. 3.75 GHz was the maximum tuning range of repetition rate at present.
A broadband continuously tunable semiconductor disk laser is reported in this paper. The active region of gain chip is composed of InGaAs multiple quantum wells with resonant periodic gain structure, and its fluorescence peak wavelength is around 965 nm. Using the wideband characteristics of the quantum wells in gain chip, along with the simple linear cavity that is formed by a high reflectivity external mirror, the laser has a low cavity loss and a wide tuning range. The continuously tunable laser wavelength can be obtained by inserting birefringent filters with different thickness into the cavity. When the thickness of the birefringent filter is 2 mm, the wavelength tuning range of the laser is 45 nm, the maximum output power is 122 mW, and the beam quality <i>M</i><sup>2</sup> factors in the <i>X-</i> and the <i>Y-</i>directions are 1.00 and 1.02, respectively. The temperature characteristics of the surface-emitting spectra of gain chip and the narrowing effect of birefringent filter on laser linewidth h are also discussed.
Although the prognosis for most patients with papillary thyroid cancer (PTC) is good, the present treatment is ineffective for 5-10% patients. Several studies found sodium-glucose cotransporter 2 (SGLT2) inhibitors may inhibit the growth of tumors. However, whether SGLT2 inhibitors have therapeutic effect on thyroid cancer remains unclear.The levels of SGLT2 in PTC and normal thyroid tissue were assessed by immunohistochemistry and clinical dataset analysis. Cell growth was detected by the CCK-8 and colony formation. Glucose uptake into thyroid cancer cell was evaluated by 2-DG uptake assay. Glycolysis were analyzed by Seahorse XF Extracellular Flux Analysis. RNA-seq were used to screen differentially expressed genes of cells treated with/without canagliflozin (a SGLT2 inhibitor). Furthermore, flow cytometry, western blot, and gene set enrichment analysis were employed to elucidate cell cycle, apoptosis and the underlying mechanism of the anticancer effect of canagliflozin. The effect of canagliflozin on thyroid cancer growth was further confirmed in vivo through xenograft formation assay.SGLT2 inhibition attenuated the growth of thyroid cancer cells in vitro and in vivo. Canagliflozin inhibited glucose uptake, glycolysis and AKT/mTOR signaling activation, and increased AMPK activation in thyroid cancer cell. Furthermore, canagliflozin inhibited G1/S phase transition and cyclin D1, cyclin D3, cyclin E1, cyclin E2, and E2F1 expression levels in thyroid cancer cell. In addition, canagliflozin increased apoptosis of thyroid cancer cell. Further investigation revealed that canagliflozin could increase γ-H2AX expression levels and DNA damage response signaling ATM/CHK2 activation. In thyroid cancer patients, SGLT2 was increased in thyroid cancer and positively related to cyclin D3.SGLT2 inhibition may limit glucose uptake resulting in energetic crisis, following oxidative stress mediated DNA damage and cell cycle arrest, which resulted to the increased cell apoptosis and decreased proliferation of thyroid cancer cells, suggesting a potential use for SGLT2 inhibitors as thyroid cancer therapeutics.
Objective:To explore the mechanism of HHT induced apoptosis in leukemic T cells Molt 3 Methods:Flow cytometry ,colorimetric assay and RT PCR were used to analyse the HHT induced apoptotic pathways Results:We studied dose and time dependent effects of HHT on cell viability, cell cycle distribution, Caspase 3 activity as well as expression of Fas on Molt 3 cells In these cells, HHT induced apoptosis was associated with G1 delay and correlated with the activation of Caspase 3 Treatment with Caspase 3 inhibitor prevent HHT induced apoptosis significantly Pretreatment of Molt 3 cells with HHT did not increase the susceptibility to apoptosis induced by crosslinking of Fas receptors Furthermore, Fas L neutralizing antibodies (Nok 1 and 2) did not affect HHT induced apoptosis in these cells Conclusion:HHT induced apoptosis in Molt 3 cells involves the activation of Caspase 3
Highly conductive polymer films on plastic substrates are desirable for the application of flexible electronics. Here, we report the conductivity of poly(3,4-ethylenedioxythiophene): poly(styrenesulfonate) (PSS) can be enhanced to 1460 S/cm via phosphoric acid (H3PO4) treatment. The conductivity enhancement is associated with the partial removal of PSS from the film. The H3PO4 treatment is compatible with plastic substrates, while sulfuric acid (H2SO4) can easily damage the plastic substrate. With the flexible electrode of poly(ether sulfone) (PES)/H3PO4-treatedPSS, we have demonstrated flexible all-plastic solar cells (PES/H3PO4-treatedPSS/PEI/P3HT:ICBA/EG-PEDOT:PSS). The cells exhibit an open-circuit voltage of 0.84 V, a fill factor of 0.60, and a power conversion efficiency of 3.3% under 100 mW/cm(2) white light illumination.
Traditional wound dressings mainly participate in the passive healing processes and are rarely engaged in active wound healing by stimulating skin cell behaviors. Electrical stimulation (ES) has been known to regulate skin cell behaviors. Herein, a series of multifunctional hydrogels based on regenerated bacterial cellulose (rBC) and MXene (Ti3 C2 Tx ) are first developed that can electrically modulate cell behaviors for active skin wound healing under external ES. The composite hydrogel with 2 wt% MXene (rBC/MXene-2%) exhibits the highest electrical conductivity and the best biocompatibility. Meanwhile, the rBC/MXene-2% hydrogel presents desired mechanical properties, favorable flexibility, good biodegradability, and high water-uptake capacity. An in vivo study using a rat full-thickness defect model reveals that this rBC/MXene hydrogel exhibits a better therapeutic effect than the commercial Tegaderm film. More importantly, in vitro and in vivo data demonstrate that coupling with ES, the hydrogel can significantly enhance the proliferation activity of NIH3T3 cells and accelerate the wound healing process, as compared to non-ES controls. This study suggests that the biodegradable and electroactive rBC/MXene hydrogel is an appealing candidate as a wound dressing for skin wound healing, while also providing an effective synergistic therapeutic strategy for accelerating wound repair process through coupling ES with the hydrogel dressing.
We report on vacuum-free and metal electrode–free organic tandem solar cells that use conducting polymer poly(3,4-ethylenedioxythiophene):poly(styrenesulfonate) (PEDOT:PSS) as the top electrode. The PEDOT:PSS top electrode was deposited via film-transfer lamination that does not need high-vacuum processing. The fabricated tandem solar cells exhibit an open-circuit voltage of 1.62 V, which is nearly the sum of the VOC of individual subcells, a high fill factor up to 0.72, and averaged power conversion efficiency of 3.6% under 100 mW cm−2 AM 1.5 illumination. The effect of the patterning of charge recombination layer and electrodes on the device performance has also been discussed.
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