Abstract Endovascular repair of abdominal aortic aneurysm (AAA) was attempted in ten patients over a 12-month period. Median age was 72 (range 61–82) years and median AAA diameter was 5·5 (range 5·2–6·0) cm. An aortoaortic (tube) graft was used in seven patients and a tapered aortoiliac reconstruction in three. There were two failures requiring conversion to open repair. Additional procedures included iliac artery angioplasty (two), coil embolization of an associated common iliac aneurysm (one) and femorodistal bypass (one). Median operating time was 162 (range 95–270) min and median blood loss was 1200 (range 800–2000) ml. Median hospital stay was 9 (range 5–21) days. Complications included death (one), reversible acute tubular necrosis (one) and prolonged ventilation (one). Postoperative evaluation with duplex ultrasonography and computed tomography demonstrated three perigraft leaks (two proximal and one distal). It is concluded that endovascular repair of AAA is feasible but is associated with significant complications and requires careful evaluation before widespread use.

Endovascular aneurysm repair

10.1002/bjs.1800830428

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Citations (57)

Extraperitoneal bladder perforation caused by an indwelling urinary catheter

British journal of surgery (1994)

Sharon White M M Thompson J R Boyle Peter Bell

Journal Article Extraperitoneal bladder perforation caused by an indwelling urinary catheter Get access S A White, S A White Department of Surgery, Leicester Royal Infirmary, Leicester LE2 7LX, UK Correspondence to: Dr S. A. White, Department of Surgery, Leicester Royal Infirmary, Leicester LE2 7LX, UK Search for other works by this author on: Oxford Academic Google Scholar M M Thompson, M M Thompson Department of Surgery, Leicester Royal Infirmary, Leicester LE2 7LX, UK Search for other works by this author on: Oxford Academic Google Scholar J R Boyle, J R Boyle Department of Surgery, Leicester Royal Infirmary, Leicester LE2 7LX, UK Search for other works by this author on: Oxford Academic Google Scholar P R F Bell P R F Bell Department of Surgery, Leicester Royal Infirmary, Leicester LE2 7LX, UK Search for other works by this author on: Oxford Academic Google Scholar British Journal of Surgery, Volume 81, Issue 8, August 1994, Page 1212, https://doi.org/10.1002/bjs.1800810844 Published: 08 December 2005

Perforation

10.1002/bjs.1800810844

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Citations (10)

Injuries of peripheral endovascular procedures

CRC Press eBooks (2005)

Amman Bolia Peter Bell

10.1201/b13193-52

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Citations (0)

Suppl Fig 7 from Intrathecal Viral Vector Delivery of Trastuzumab Prevents or Inhibits Tumor Growth of Human HER2-Positive Xenografts in Mice

William T. Rothwell Peter Bell Laura K. Richman Maria P. Limberis Anna P. Tretiakova

<p>AAV9.trastuzumab tumor prophylaxis in the setting of continuous NK cell depletion</p>

Intrathecal

10.1158/0008-5472.22419758

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Patey Prize 03

British journal of surgery (2002)

I.M. Loftus Kevin J. Molloy Jonathan Evans Peter Bell A. Ross Naylor

Background: Loss of interstitial collagen, especially type I collagen, renders atherosclerotic plaques prone to rupture. Subsequent thrombosis and embolism may cause stroke and myocardial infarction. Initiation of collagen breakdown requires interstitial collagenases, a matrix metalloproteinase (MMP) subfamily including MMP-8. The aim of this study was to quantify the level of MMP-8, the enzyme that preferentially degrades type I collagen, in carotid plaques, and to correlate this with features of plaque instability. Methods: Plaques were retrieved from 75 consecutive patients undergoing carotid endarterectomy. MMP-8 levels were quantified using ELISA. Histological plaque sections were assessed blindly for the presence of plaque rupture and immunostaining was performed for MMP-8. All patients underwent preoperative transcranial Doppler monitoring to detect spontaneous embolization. Results expressed as median MMP-8 concentration ng mL−1 (IQR). Results: The plaque level of MMP-8 was significantly higher in patients with recent symptoms (symptoms <4 weeks), histological plaque rupture and spontaneous embolization (see Table). There was a significant correlation between MMP-8 and MMP-9 levels, a gelatinase known to be associated with plaque instability. Immunohistochemistry revealed staining for MMP-8 in areas of intense inflammatory infiltration. Discussion: The MMP-8 level is significantly higher in unstable plaques based on symptoms, histology and spontaneous embolization. Together with MMP-9, these enzymes have the potential to degrade all components of the extracellular matrix upon which plaque integrity depends, and represent a target for pharmacotherapy to prevent stroke.

Immunostaining

Stroke

10.1046/j.1365-2168.89.s.1.23_3.x

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Endovascular repair of an inflammatory aortic aneurysm

European Journal of Vascular and Endovascular Surgery (1997)

J.R. Boyle Matt Thompson A. Nasim Shu Ye M V Holmes

Endovascular aneurysm repair

10.1016/s1078-5884(97)80106-2

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Citations (32)

Detection of symptomless cerebral emboli

The Lancet (1994)

Michael E. Gaunt J L Smith Peter J. Martin David H. Evans Peter Bell

10.1016/s0140-6736(94)92983-1

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Citations (3)

Computing Art. A summer school for digital art history

Peter Bell

Review of the summer school for digital art history organized by the Computer Vision Group Heidelberg of the Interdisciplinary Center for Scientific Computing (IWR)

10.11588/dah.2016.2.24760

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