Xiaoxiao Ye

Shanghai Ninth People's Hospital

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Yajing Qiu

Shanghai Ninth People's Hospital

Lei Chang

Shanghai Jiao Tong University

Wenxin Yu

Shanghai Jiao Tong University

Xi Yang

Shanghai Ninth People's Hospital

Hui Chen

Reproductive & Genetic Hospital CITIC-Xiangya

Yunbo Jin

Shanghai Ninth People's Hospital

Gang Ma

Shanghai Ninth People's Hospital

Xiaoxi Lin

Shanghai Ninth People's Hospital

Dongze Lv

Shanghai Jiao Tong University

Xiaoxi Lin

Shanghai Jiao Tong University

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Shanghai Ninth People's Hospital

Shanghai Jiao Tong University

National Natural Science Foundation of China

Wenzhou Medical University

Institute for Social and Economic Research

Soochow University

Hangzhou Medical College

Zhejiang Provincial People's Hospital

Nanjing Medical University

Nanjing University

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Recurrence of Infantile Hemangioma After Termination of Propranolol Treatment

Annals of Plastic Surgery (2014)

Lei Chang Gang Ma Yunbo Jin Xiaoxiao Ye Yajing Qiu

Propranolol has been the first-line treatment for problematic infantile hemangioma (IH) since 2008. The recurrence of IHs after stopping treatment with propranolol was reported in several studies. Mechanisms underlying this phenomenon have not been elucidated so far. Our study is the first to show the general pathology of recurrence of IH after stopping treatment with propranolol. It can provide help for the clinical treatment of IHs.

Infantile hemangioma

First line treatment

10.1097/sap.0000000000000032

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Is Propranolol Safe and Effective for Outpatient Use for Infantile Hemangioma? A Prospective Study of 679 Cases From One Center in China

Annals of Plastic Surgery (2015)

Lei Chang Xiaoxiao Ye Yajing Qiu Gang Ma Yunbo Jin

The protocol for the treatment of infantile hemangioma with propranolol varies among different clinical centers.Six hundred seventy-nine patients who were 1 to 12 months old were recruited in this prospective study to receive propranolol treatment. The response to the propranolol therapy was classified as 4 levels. The results were primarily evaluated using color Doppler ultrasound examinations before and after propranolol treatment.The response was excellent in 176 (25.9%), good in 492 (72.5%), stable in 5 (0.7%), and poor in 6 (0.9%) of the patients. The mean age at the initiation of the therapy was 3.3 months (range, 1 to 10.9 months) and the mean duration of the therapy was 7.1 months (range, 3-17 months). The mean duration of the follow-up time after the discontinuation of the therapy was 5.3 months (range, 3-17 months). Regrowth of the hemangioma was observed in 92 cases (13.5%). Seventy-nine (11.6%) of the parents complained of their child's minor discomfort during the therapy.Propranolol (2 mg/kg per day) may significantly reduce the size of a hemangioma. As an outpatient therapy, propranolol was found to be safe for Chinese children and to have minor side effects.

Infantile hemangioma

Center (category theory)

10.1097/sap.0000000000000506

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Citations (37)