Phytochemical investigation of the aerial part of Laportea bulbifera (Siebold & Zucc.) Wedd. (L. bulbifera) showed the isolation of seventeen compounds, including five flavonoids (1-4 and 6), one terpenoid (5), five phenolic acids (7-11), one coumarin (12), two steroids (13-14), and three alkaloids (15-17). Structure elucidations of these compounds were performed on the basis of extensive NMR experiments and compared with the published data in the references. It is remarkable that compounds (3-5) were firstly isolated from the Urticaceae family, compounds (3-8, 11 and 15-17) were firstly obtained from genus Laportea. Furthermore, the result of the chemotaxonomic significance discussion showed that compounds (2-4) may can be served as compound fingerprints to distinguish between species of L. bulbifera and genus Urtica, and what' more, we proposed a bold conjecture that isoflavones can distinguish between species of L. bulbifera and genus Urtica. At the same time, the molecular docking method was used to evaluate the inhibitory effect of these compounds on human steroid 5α-reductase 2 (SRD5α2). The results showed that compounds (1-4 and 6) had better expected effects than the positive drug finasteride can by effectively binding to the active sites of SRD5α2. This study assisted in the future phytochemical and chemotaxonomic research on genus Laportea. Simultaneously, this research provided the theoretical evidence for the application of L. bulbifera in treating benign prostatic hyperplasia (BPH).
Objective
To observe the change of structure of the macular after cataract surgery.
Methods
The data of 98 eyes of 68 cases with age related cataract who received phacoemulsification and intraocular lens implantation from Aug. 2013 to Sep. 2015 in our hospital were retrospectively analyzed.The results of visual acuity, anterior segment of eye and fundus were recorded. Spectral domain optical coherence tomography (SD-OCT) was used to measure the fundus 1 month after the surgery.
Results
The cataract surgery was performed successfully in all 98 eyes and the postoperative best corrected visual acuity(BCVA) was improved compared with preoperative one.No abnormal change of macular area was found by direct and indirect ophthalmoscopy 1 month after the surgery .The spectralis SD-OCT showed no significant change of the macular thickness except for slight increase of the central macular thickness, which was (209.28±25.16)μm compared with(187.71±31.65)μm of normal people at the same age, and the difference was not statistically significant. However, the slightly abnormal continuity of the IS/OS layer and integrity of the RPE layer appeared in some patients with poor visual acuity recovery.Epimacular membrane formed in 5 eyes.
Conclusion
The macular thickness 1 month after phacoemulsification in age-related cataract patients without other general or ocular diseases is similar to the normal one. A few patients with poor visual acuity recovery is probably due to the changes of continuity of the IS/OS layer or the integrity of the RPE layer.
Key words:
Cataract; Phacoemulsification; Lens, intraocular; Visual acuity; Optical coherence tomography, spectral domain
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