Leyla Karadeniz

Ümraniye Eğitim ve Araştırma Hastanesi

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Co-Authors

Gülay Can

Istanbul University

Zİ

Zeynep İnce

Istanbul University

AÇ

Asuman Çoban

Istanbul University

ÜT

Ümit Türkoğlu

Istanbul University

Francesco Savino

University of Bari Aldo Moro

Myriam Bickle Graz

University of Lausanne

R Miniero

Azienda Ospedaliera Pugliese Ciaccio

Diantha B. Howard

University of Vermont Medical Center

Gilberto Kac

Universidade Federal do Rio de Janeiro

Richard Plavka

Charles University

Cooperative Institutions

Sağlık Bilimleri Üniversitesi

Pediatrics and Genetics

Zeynep Kamil Hospital

Istanbul University

Ministry of Health

University of Health Science

Ümraniye Eğitim ve Araştırma Hastanesi

University of Health Sciences

Marmara University

İstanbul Eğitim ve Araştırma Hastanesi

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Magnetic Resonance Imaging Findings in Patients With Severe Neonatal Indirect Hyperbilirubinemia

Journal of Child Neurology (2001)

Yılmaz Yüksel Gülay Alper Gamze Kılıçoğlu Levent Çelìk Leyla Karadeniz

The aim of this study was to document the magnetic resonance imaging (MRI) findings of cases with a history of severe neonatal indirect hyperbilirubinemia. Ten cases (eight cases with neurologic findings, two normal cases) with a history of severe neonatal indirect hyperbilirubinemia were studied. Neurologic findings and MRI results were described and correlated. Seven of eight cases with neurologic findings demonstrated symmetric and uniform increased T2 signal changes limited to globus pallidi. MRI scans of two cases without neurologic findings showed no abnormality. Severe neonatal indirect hyperbilirubinemia should be considered in the differential diagnosis of bilateral symmetric hyperintense signal changes in the globus pallidus on MRI. However, high levels of unconjugated bilirubin concentrations in the neonatal period may not always cause such lesions of globus pallidus on MRI despite the presence of neurologic findings.

Abnormality

10.1177/088307380101600615

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Citations (43)

Vein of Galen aneurysmal malformation: Prenatal diagnosis and early endovascular management

Journal of the Chinese Medical Association (2011)

Leyla Karadeniz Asuman Çoban Serra Sencer Recep Has Zeynep İnce

A prenatally diagnosed patient was referred to our hospital at 35 weeks of gestation. Antenatal ultrasonography demonstrated cardiomegaly and aneurysm of the vein of Galen. A 3,290 g male baby was delivered by elective cesarean section at 37 weeks of gestation. Physical examination was remarkable for tachypnea, hyperdynamic precordium with a continuous murmur, cranial bruit and bounding carotid pulses. Magnetic resonance angiography confirmed vein of Galen aneurysmal malformation and demonstrated the vessels feeding the aneurysm. Postnatal management included aggressive medical treatment of cardiac failure and transarterial embolization of the vessels feeding the aneurysm at 3 days of age. Posthemorrhagic hydrocephalus developed after embolization, and a ventriculo-peritoneal shunt was placed at 29 days of age. Presently, the patient is 4 years of age and has no neurological abnormality at follow-up. Vein of Galen aneurysmal malformations can cause severe morbidity and mortality in neonates. However, careful obstetric follow-up and early postnatal endovascular treatment of these malformations may lead to a favorable outcome.

Arteriovenous malformation

10.1016/j.jcma.2011.01.029

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Citations (31)

Hipoksik iskemik ensefalopatili 76 term yenidoğanın klinik özellikleri

Medical Network Klinik Bilimler ve Doktor (1999)

Yüksel Yılmaz Leyla Karadeniz Belgin Erdoğan Feray Güven Feyza Yıldız

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An unusual cause of respiratory distress: unilateral pulmonary agenesis

Archives of Disease in Childhood Fetal & Neonatal (2001)

Şirin Güven Y KOYUTÜRK Ayşenur Cerrah Celayir Leyla Karadeniz S Celikoğlu

A 7 year old boy was admitted with severe respiratory distress. A chest x ray film showed diffuse opacity of the right hemithorax and a slightly overdistended left lung with patchy infiltrates; the cardiac silhouette was shifted to the right (fig 1). Despite treatment with intravenous …

10.1136/fn.84.3.f197

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Citations (8)

Author Index Vol. 97, 2010

Neonatology (2010)

C Mercier Michael Dunn Karla Ferrelli Diantha B. Howard Roger F. Soll

10.1159/000316591

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Cord Blood Cardiac Troponin T and Nonprotein-Bound Iron Levels in Newborns of Mild Pre-Eclamptic Mothers

Neonatology (2009)

Leyla Karadeniz Asuman Çoban Zeynep İnce Ümit Türkoğlu Gülay Can

Background: In hypoxic newborns, cardiac troponin T (cTnT) was shown to be an indicator of cardiac damage and increased levels of nonprotein-bound iron (NPBI), an indicator of increased free radical production and perinatal brain damage. Objective: The aim of this study was to determine cord blood cTnT and NPBI levels in neonates of mild pre-eclamptic mothers. Methods: The study included 50 babies of mild pre-eclamptic mothers and 50 babies of healthy mothers. cTnT and NPBI levels were measured in cord blood. Results: The mean gestational age in the pre-eclamptic and healthy groups were 36.1 ± 3.5 and 38.1 ± 1.9 weeks, mean birth weights were 2,456 ± 945 and 3,059 ± 493 g. Cord blood median cTnT level was significantly higher in the pre-eclamptic group (0.024 vs. 0.015 ng/ml). Serum cTnT in the 95th percentile was 0.047 ng/ml in the healthy group. cTnT levels of preterm babies in the pre-eclamptic group was found to be significantly higher compared to term babies in the control group (0.038 vs. 0.013 ng/ml). It could not be demonstrated whether there is a statistically significant relation between cTnT levels and respiratory distress, gestation, type of delivery, sex and birth weight. The median NPBI level was higher in the control group (3.26 vs. 1.86 µmol/l). Conclusions: Increased levels of cTnT may be a biochemical marker of cardiac involvement in babies of mild pre-eclamptic mothers. In this study, no correlation was found between cTnT levels and NPBI levels.

Troponin complex

Cord blood

Troponin T

10.1159/000255162

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Citations (11)

The utility of maternal mean platelet volume levels for early onset neonatal sepsis prediction of term infants

Ginekologia Polska (2017)

Yasemin Çekmez Merve Dizdar Güleçoğlu Cemile Özcan Leyla Karadeniz Gürkan Kıran

This study is aimed to evaluate the role of maternal mean platelet volume (MPV) levels for antenatal prediction marker of early onset neonatal sepsis in term infants born to mothers who have low infection risk.A total of 62 pregnant women who gave birth in our hospital and whose neonates were admitted to a third level Neonatal Intensive Care Unit due to confirmed neonatal sepsis between January 2010 and May 2016 were selected as a study group. Within the same period, 68 women who gave birth to healthy neonates were enrolled as a control group. We compared maternal MPV values which were evaluated before delivery. The receiver operating characteristic (ROC) curves were drawn to evaluate the values maternal MPV in the diagnosis of neonatal sepsis.MPV levels were detected statistically higher in the study group than the control group (8.27 ± 1.85 vs. 8.98 ± 1.16) (p = 0.001).The maternal serum MPV level is a clinically useful, non-invasive and reliable marker in antenatal prediction of EOS.

Mean platelet volume

Neonatal Sepsis

Full Term

10.5603/gp.a2017.0058

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Citations (11)

25th International Workshop on Surfactant Replacement, Moscow, June 10–12, 2010

Neonatology (2010)

C Mercier Michael Dunn Karla Ferrelli Diantha B. Howard Roger F. Soll

10.1159/000297772

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Wolff- Parkinson-White Elektrokardiyografik Paterni Saptanan Çocuklarda Klinik Değerlendirme ve Semptomatik Olguların Sunumu

Filiz Ekici İbrahim İlker Çetin Leyla Karadeniz

Aims: To evaluate the children with electrocardiographic pattern of Wolff-Parkinson-White (WPW) and review their demographic features, presenting symptoms, electrocardiographic, echocardiographic findings, and management. Methods: The study was conducted in a single tertiary research hospital from 2009 to 2011, retrospectively. Twentyone children (1 day to 15 years) with a WPW pattern on surface ECG were included in this study. We classified patients into two groups as “Asymptomatic” and “Symptomatic Group”. Results: Most children were asymptomatic (13 cases, mean age: 6.0 years) at the diagnosis and during the study period. Symptoms related to dysrhtyhmia were recognized in 8 cases (mean age: 9.1 years) and most common in school age children. There were no gender predominance between two groups. The symptoms were palpitations in 4 cases and syncope in one case. Three cases presented with attack of supraventricular tachycardia (SVT). They also had intermittent nature of WPW and male predominance. Echocardiography revealed mitral valve prolapsus in 7, hypertrophic cardiomyopathy in 3, aortic regurgitation in 1 and Ebstein abnormality in 1 case. SVT were successfully treated with Amiodoron or Adenosine. No patient died suddenly during the study period. Conclusion: Children with electrocardiographic pattern of WPW should be recognized and managed properly.

Palpitations

Supraventricular Tachycardia

Mitral valve prolapse

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Sol akciğer ve safra kesesi agenezisi ile birlikte bilateral diyafragma agenezisi

Zeynep Kamil Tıp Bülteni (2008)

Leyla Karadeniz Şirin Güven Enver Atay Fahri Ovalı Osman Zeki Pektaş

Bilateral agenesis of diaphragm with agenesis of left lung and gall bladder Background: Although congenital diaphragmatic hernia is one of the most common congenital anomalies, complete bilateral agenesis of the diaphragm is a very rare congenital malformation and associated frequently with other major anomalies. We report a case of bilateral diaphragmatic agenesis associated with major congenital anomalies. Case: A 2240g male infant was born at 35 weeks' gestation to a 34-year-old mother with a history of minimal prenatal care. Polyhydramnios was reported on prenatal level 1 scan. He experienced early respiratory distress requiring intubation. Apgar scores were 2/1/1 at 1, 5 and 20 minutes, respectively and efforts to resuscitate him were unsuccessful. He died at 2 hours of age. Autopsy revealed bilateral diaphragmatic agenesis associated with right pulmonary hypoplasia, left pulmonary agenesis, multiple cardiac abnormalities and gall bladder agenesis. Cytogenetic studies showed normal male karyotype. Conclusions: Bilateral agenesis of the diaphragm is a life-threatening malformation. Survival of these infants often depends on cardiopulmonary function. Also, bilateral agenesis of the diaphragm associated with gall bladder and unilateral pulmonary agenesis is a rare entity and its clinical significance needsfurther investigation.

Agenesis

Polyhydramnios

Pulmonary Hypoplasia

Diaphragm (acoustics)

10.16948/zktb.93605

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