Lu Gao

Sichuan University

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Zhenlei Song

Sichuan University

Qiu‐Fen Hu

Yunnan Academy of Agricultural Sciences

Han‐Dong Sun

Kunming Institute of Botany

Wei‐Lie Xiao

Yunnan University

Jian‐Xin Pu

Chinese Academy of Sciences

Ji Lu

Southwest Medical University

Wanshu Wang

Sichuan University

Yanqing Ye

Minzu University of China

Linjie Li

University of Gothenburg

Yin-Ke Li

Yunnan Academy of Agricultural Sciences

Cooperative Institutions

Sichuan University

185

Chinese Academy of Sciences

128

Peking University

Chinese Academy of Medical Sciences & Peking Union Medical College

University of Chinese Academy of Sciences

Shanghai Jiao Tong University

Zhejiang University

Sun Yat-sen University

Central South University

Yunnan University

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Substrate-controlled divergent synthesis withortho-vinyl-functionalised 1,3-enynes and iminesviapalladium catalysis

Organic Chemistry Frontiers (2023)

Bo Zhu Teng Sun Zhichao Chen Lu Gao Wei Du

Substrate-controlled divergent cascade reactions between ortho -vinyl-functionalised 1,3-enynes and imines have been realised via palladium catalysis, furnishing collections of skeletally distinct architectures in good yields and stereoselectivity.

Divergent synthesis

10.1039/d3qo00714f

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Citations (3)

Total Syntheses of Bryostatins 1, 7, 9 and 9‐N3

Angewandte Chemie (2025)

Qianyou Guo Yufan Yang Hongyun Zhang Dongxu Wang Bing Li

Bryostatins are a family of marine natural products that have garnered significant interests, as evidenced by over 40 clinical trials. However, their extremely low natural abundance has severely limited further research. Despite significant efforts, which have led to the total synthesis of seven bryostatin members by eight independent research groups, these complex molecules present persistent challenges for stereocontrolled, large‐scale, and especially divergent synthesis. Here, we report the divergent total syntheses of bryostatins 1, 7, 9 and 9‐N3. Notably, 1.5 g of bryostatin 1 was obtained in a single sequence of the final three steps. Key transformations include Ni‐catalyzed reductive cross‐coupling to rapidly assemble the northern fragment, the flow chemistry‐assisted visible light‐induced alkyl radical conjugate addition to convergently construct the southern fragment, and an intramolecular geminal bis(silyl) Prins cyclization to establish the cis‐Z selectivity on the B‐ring. The syntheses consist of 20–22 steps in the longest linear sequence and 33–35 total steps, with overall yields ranging from 3.3% to 4.5%.

10.1002/ange.202423465

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Total Synthesis of Bryostatin 8 Using an Organosilane‐Based Strategy

Angewandte Chemie International Edition (2017)

Yuebao Zhang Qianyou Guo Xianwei Sun Ji Lu Yanjun Cao

Abstract Convergent total synthesis of bryostatin 8 has been accomplished by an organosilane‐based strategy. The C ring is constructed stereoselectively through a geminal bis(silane)‐based [1,5]‐Brook rearrangement, and the B ring through geminal bis(silane)‐based Prins cyclization, thus efficiently joining the northern and southern parts of the molecule.

Geminal

Prins reaction

10.1002/anie.201711452

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Citations (42)

Anti-Tobacco Mosaic Virus Chromones from the Twigs of Cassia fistula

Chemistry of Natural Compounds (2017)

Qiu‐Fen Hu Ye‐De Wang Zhenhua Yu Kun Zhou Wei Dong

Mosaic virus

10.1007/s10600-017-2021-4

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Recent Progress in the Synthesis of Silaspiranes

Chemistry - A European Journal (2023)

Hua Chen Xuejiao Hu Wanshu Wang Lu Gao Zhenlei Song

Abstract Silaspiranes bearing a spiro‐silicon center are promising ring frameworks for the synthesis of novel spirocyclic molecules possessing unique properties. Development of efficient methods towards these ring structures has therefore attracted considerable attentions of synthetic chemists. This minireview highlights the representative advances in the field, and is categorized into four parts according to the ring formation strategies: cyclization, annulation, ring expansion and cycloaddition.

Annulation

10.1002/chem.202302371

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Citations (5)

Flavones from the Bark of Lindera caudata and Their Anti‐Tobacco Mosaic Virus Activity

Bulletin of the Korean Chemical Society (2015)

Yuchun Yang Ying Qin Xianxue Wu Cong‐Fang Xia Yanlin Meng

Two new flavones, 5‐hydroxy‐8‐hydroxymethyl‐7,4′‐dimethoxy‐flavone ( 1 ) and 6‐hydroxy‐8‐hydroxymethyl‐7,4′‐dimethoxy‐flavone ( 2 ), together with six known flavones ( 3–8 ), were isolated from the bark of Lindera caudata . The structures of 1–8 were elucidated by spectroscopic methods including extensive 1D and 2D NMR techniques. Compounds 1–8 were evaluated for their anti‐tobacco mosaic virus (anti‐ TMV ) activity. The results showed that Compounds 1 and 2 showed high anti‐ TMV activity with inhibition rates of 31.2 and 28.8%, respectively. These values are close to those of positive control.

Flavones

Hydroxymethyl

Mosaic virus

10.1002/bkcs.10216

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Midpalatal Suture CBCT Image Quantitive Characteristics Analysis Based on Machine Learning Algorithm Construction and Optimization

Bioengineering (2022)

Lu Gao Zhiyu Chen Lin Zang Zhipeng Sun Qing Wang

Midpalatal suture maturation and ossification status is the basis for appraising maxillary transverse developmental status.We established a midpalatal suture cone-beam computed tomography (CBCT) normalized database of the growth population, including 1006 CBCT files from 690 participants younger than 24 years old. The midpalatal suture region of interest (ROI) labeling was completed by two experienced clinical experts. The CBCT image fusion algorithm and image texture feature analysis algorithm were constructed and optimized. The age range prediction convolutional neural network (CNN) was conducted and tested.The midpalatal suture fusion images contain complete semantic information for appraising midpalatal suture maturation and ossification status during the fast growth and development period. Correlation and homogeneity are the two texture features with the strongest relevance to chronological age. The overall performance of the age range prediction CNN model is satisfactory, especially in the 4 to 10 years range and the 17 to 23 years range, while for the 13 to 14 years range, the model performance is compromised.The image fusion algorithm can help show the overall perspective of the midpalatal suture in one fused image effectively. Furthermore, clinical decisions for maxillary transverse deficiency should be appraised by midpalatal suture image features directly rather than by age, especially in the 13 to 14 years range.

10.3390/bioengineering9070316

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Citations (10)

Synthesis of unsymmetrical diarylmethanols via C–Si bond bifunctionalization enabled by sequential [1,4]-Csp² to O-silyl migration

Organic Chemistry Frontiers (2019)

Tianbao Hu Liying Huang Lu Gao Zhenlei Song

Unsymmetrical C–Si bond bifunctionalization of 2,2′-bis(trimethylsilyl) diphenylmethanol via “on–off–on” sequential [1,4]-Csp² to O-silyl migration installs Csp³/Csp³, Csp³/Csp² or Csp²/Csp³ in one pot, giving sterically congested unsymmetrical diarylmethanols in good yields.

10.1039/c9qo01450k

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Citations (2)

Enantioselective synthesis of crotyl geminal bis(silane) and its usage for asymmetric Sakurai allylation of acetals

Tetrahedron (2017)

Yang Chu Qiang Pu Zhixing Tang Lu Gao Zhenlei Song

Geminal

10.1016/j.tet.2017.05.011

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Citations (7)

ChemInform Abstract: Recent Efforts to Construct the B‐Ring of Bryostatins

ChemInform (2013)

Lu Gao Ji Lu Zhenlei Song

Abstract Review: 120 refs.

10.1002/chin.201351265

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Citations (0)