Shuian-Yin Lin

National Applied Research Laboratories

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Hsieh‐Chih Tsai

National Taiwan University of Science and Technology

Tilahun Ayane Debele

University of Cincinnati

Shewaye Lakew Mekuria

Donghua University

Chun-Liang Lo

National Yang Ming Chiao Tung University

Wei-Hsin Hsu

National Tsing Hua University

Ging-Ho Hsiue

National Tsing Hua University

Wei-Yu Zhao

National Chung Hsing University

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National Tsing Hua University

National Taiwan University of Science and Technology

Chung Yuan Christian University

National Yang Ming Chiao Tung University

University of Gondar

National Yang Ming University Hospital

ITRI International

Mackay Memorial Hospital

Mackay Medical College

Taipei Medical University

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Synthesis and characterization of bioreducible heparin-polyethyleneimine nanogels: application as imaging-guided photosensitizer delivery vehicle in photodynamic therapy

RSC Advances (2016)

Tilahun Ayane Debele Shewaye Lakew Mekuria Shuian-Yin Lin Hsieh‐Chih Tsai

HPC nanogels possess bright blue fluorescence which eliminates the use of additional probing agents in image-guided drug delivery. The results showed that disulfide crosslinked HPC nanogels are promising vehicles for stimulated photosensitizer delivery in advanced PDT.

10.1039/c5ra25650j

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Sterically Polymer-Based Liposomal Complexes with Dual-Shell Structure for Enhancing the siRNA Delivery

Biomacromolecules (2012)

Shuian-Yin Lin Wei-Yu Zhao Hsieh‐Chih Tsai Wei-Hsin Hsu Chun-Liang Lo

The sterically polymer-based liposomal complexes (SPLexes) were formed by cationic polymeric liposomes and pH-sensitive diblock copolymer were studied for their capabilities in improving the stability with high efficiency of siRNA delivery. The SPLexes were formed a dual-shelled structure and uniform size distribution. The PEGylated outer shell could mitigate the phagocytosis and reduce the cytotoxicity. Moreover, the folated SPLexes improved 42.9× accumulation in vitro and 1.7× tumor uptake in vivo in contrast with nonfolated SPLexes. The protonated copolymer at low pH would improve the siRNA released into cytoplasm following SPLexes fusion with the endo/lysosome membrane and inhibited the protein expression to 75.6 ± 4.5% efficiently. Results of this study significantly contribute to efforts to develop lipoplexes based siRNA delivery systems.

Cationic polymerization

10.1021/bm201746t

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Citations (29)