Laurent Gauthier

CEA Paris-Saclay - Etablissement de Fontenay-aux-roses

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François D. Boussin

Université Paris Cité

Bernard S. López

Centre National de la Recherche Scientifique

Fabienne Lebrun

Institut Jules Bordet

Isabelle Plo

Inserm

Corentin Laulier

City of Hope

Fabien Calvo

Hôpital Saint-Louis

Claudine Schiff

Centre d’Immunologie de Marseille-Luminy

Peter Neumann

Agroscope

Benjamin Dainat

Agroscope

Christine Granotier

Commissariat à l'Énergie Atomique et aux Énergies Alternatives

Cooperative Institutions

Inserm

189

Centre National de la Recherche Scientifique

181

Commissariat à l'Énergie Atomique et aux Énergies Alternatives

104

Université Paris Cité

Université Paris-Saclay

CEA Paris-Saclay - Etablissement de Fontenay-aux-roses

CEA Paris-Saclay

Aix-Marseille Université

Institut de Radiobiologie Cellulaire et Moléculaire

Centre d’Immunologie de Marseille-Luminy

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Long-term controlled immortalization of a primate hepatic progenitor cell line after Simian virus 40 T-Antigen gene transfer

Oncogene (2004)

Jean-Paul Delgado Alexandre Parouchev Jean-Étienne Allain Gaëlle Pennarun Laurent Gauthier

Immortalised cell line

Progenitor

Cre recombinase

clone (Java method)

10.1038/sj.onc.1208089

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Citations (36)

Supplementary Figure 6 from AKT1 Inhibits Homologous Recombination by Inducing Cytoplasmic Retention of BRCA1 and RAD51

Isabelle Plo Corentin Laulier Laurent Gauthier Fabienne Lebrun Fabien Calvo

Supplementary Figure 6 from AKT1 Inhibits Homologous Recombination by Inducing Cytoplasmic Retention of BRCA1 and RAD51

10.1158/0008-5472.22377140

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Citations (0)

Characterization of a triboluminescent optical sensor for detecting particles

Proceedings of SPIE, the International Society for Optical Engineering/Proceedings of SPIE (2009)

Laurent Gauthier M. E. Jansen J. R. Meyer

Common sub-millimeter particle impact phenomena range from zero to thousands of joules of impact energy. The physics of impacts are associated with a wide variety of physical phenomena, including the generation of heat, light, and sound. Although higher energy impact events may result in vaporization of the impacted material and other easily detectable effects, lower energy level impacts of interest may occur with little obvious physical effect. Preliminary research with capacitative sensors provided encouraging results for detecting low-energy impacts. However, vibration within the sensor mounting structure interfered with the detection of impact events. Research on triboluminescent phosphors indicated that a thin layer of material could be used to form the basis of an optical sensor to detect small particle impacts without interference from structural vibrations. A ZnS:Mn phosphor was used as the basis for developing a triboluminescent fiber optic sensor to detect small particle impact events. Detection of impacts is accomplished by detecting the optical pulse that is generated by the abrupt charge separation caused by the particle impact within the phosphor. Laboratory-based experiments were performed to capture the operational characteristics of the sensor. The data are used to study the characteristic response, sensor repeatability, and spatial homogeneity of the detection surface. Tests were also performed to identify the energy detection boundary and to assess environmental survivability. Results of these tests are reported in this paper.

Survivability

10.1117/12.819252

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Functional interplay between Parp-1 and SirT1 in genome integrity and chromatin-based processes

Cellular and Molecular Life Sciences (2009)

Rosy El Ramy Najat Magroun Nadia Messadecq Laurent Gauthier François D. Boussin

Chromatin immunoprecipitation

10.1007/s00018-009-0105-4

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Citations (53)

Comparative analysis of deformed wing virus (DWV) RNA in Apis mellifera and Varroa destructor

Diana Tentcheva Laurent Gauthier Leïla Bagny Julie Fiévet Benjamin Dainat

Deformed wing virus

Destructor

Source

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Citations (11)

The Apis mellifera Filamentous Virus Genome

Viruses (2015)

Laurent Gauthier Scott Cornman Ulrike Hartmann François Cousserans Jay D. Evans

A complete reference genome of the Apis mellifera Filamentous virus (AmFV) was determined using Illumina Hiseq sequencing. The AmFV genome is a double stranded DNA molecule of approximately 498,500 nucleotides with a GC content of 50.8%. It encompasses 247 non-overlapping open reading frames (ORFs), equally distributed on both strands, which cover 65% of the genome. While most of the ORFs lacked threshold sequence alignments to reference protein databases, twenty-eight were found to display significant homologies with proteins present in other large double stranded DNA viruses. Remarkably, 13 ORFs had strong similarity with typical baculovirus domains such as PIFs (per os infectivity factor genes: pif-1, pif-2, pif-3 and p74) and BRO (Baculovirus Repeated Open Reading Frame). The putative AmFV DNA polymerase is of type B, but is only distantly related to those of the baculoviruses. The ORFs encoding proteins involved in nucleotide metabolism had the highest percent identity to viral proteins in GenBank. Other notable features include the presence of several collagen-like, chitin-binding, kinesin and pacifastin domains. Due to the large size of the AmFV genome and the inconsistent affiliation with other large double stranded DNA virus families infecting invertebrates, AmFV may belong to a new virus family.

ORFS

DNA virus

10.3390/v7072798

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Citations (85)

Huntingtin Controls Neurotrophic Support and Survival of Neurons by Enhancing BDNF Vesicular Transport along Microtubules

Cell (2004)

Laurent Gauthier Bénédicte C. Charrin María Borrell‐Pages Jim Dompierre Hélène Rangone

10.1016/j.cell.2004.06.018

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Citations (1,126)

TGFβ Lengthens the G1 Phase of Stem Cells in Aged Mouse Brain

Stem Cells (2014)

Mathieu Daynac José Ramón Pineda Alexandra Chicheportiche Laurent Gauthier Lise Morizur

Neurogenesis decreases during aging causing a progressive cognitive decline but it is still controversial whether proliferation defects in neurogenic niches result from a loss of neural stem cells or from an impairment of their progression through the cell cycle. Using an accurate fluorescence-activated cell sorting technique, we show that the pool of neural stem cells is maintained in the subventricular zone of middle-aged mice while they have a reduced proliferative potential eventually leading to the subsequent decrease of their progeny. In addition, we demonstrate that the G1 phase is lengthened during aging specifically in activated stem cells, but not in transit-amplifying cells, and directly impacts on neurogenesis. Finally, we report that inhibition of TGFβ signaling restores cell cycle progression defects in stem cells. Our data highlight the significance of cell cycle dysregulation in stem cells in the aged brain and provide an attractive foundation for the development of anti-TGFβ regenerative therapies based on stimulating endogenous neural stem cells.

10.1002/stem.1815

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Citations (37)

Supplementary Movie from AKT1 Inhibits Homologous Recombination by Inducing Cytoplasmic Retention of BRCA1 and RAD51

Isabelle Plo Corentin Laulier Laurent Gauthier Fabienne Lebrun Fabien Calvo

Supplementary Movie from AKT1 Inhibits Homologous Recombination by Inducing Cytoplasmic Retention of BRCA1 and RAD51

10.1158/0008-5472.22377137.v1

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Citations (0)

Supplementary Figure 2 from AKT1 Inhibits Homologous Recombination by Inducing Cytoplasmic Retention of BRCA1 and RAD51

Isabelle Plo Corentin Laulier Laurent Gauthier Fabienne Lebrun Fabien Calvo

Supplementary Figure 2 from AKT1 Inhibits Homologous Recombination by Inducing Cytoplasmic Retention of BRCA1 and RAD51

Non-homologous end joining

10.1158/0008-5472.22377155.v1

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Citations (0)