Jérémie Fournier-Dit-Chabert

Université Clermont Auvergne

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Sylvie Ducki

Institut de Chimie de Clermont-Ferrand

Laura Cosentino

Fox Chase Cancer Center

Klaus Pors

University of Bradford

J. Fernando Dı́az

Centro de Investigaciones Biológicas Margarita Salas

Vefa Ahsen

Gebze Technical University

Mariano Redondo‐Horcajo

Centro de Investigaciones Biológicas Margarita Salas

V. Vinader

University of Bradford

Steven D. Shnyder

University of Bradford

Hamdy M. Abdel‐Rahman

Assiut University

Ana Rita Santos

University of Bradford

Cooperative Institutions

University of Bradford

Gebze Technical University

Centre National de la Recherche Scientifique

Institut de Chimie de Clermont-Ferrand

Université Clermont Auvergne

Sigma Clermont

University of Oslo

Université Claude Bernard Lyon 1

University of Leeds

St James's University Hospital

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1,2,3-Triazole analogs of combretastatin A-4 as potential microtubule-binding agents

Bioorganic & Medicinal Chemistry (2010)

Kristin Odlo Jérémie Fournier-Dit-Chabert Sylvie Ducki Osman Gani Ingebrigt Sylte

Combretastatin

Triazole

1,2,3-Triazole

Molecular model

1,2,4-Triazole

10.1016/j.bmc.2010.07.032

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Citations (85)

Towards dual photodynamic and antiangiogenic agents: design and synthesis of a phthalocyanine-chalcone conjugate

Organic & Biomolecular Chemistry (2012)

Sinem Tuncel Jérémie Fournier-Dit-Chabert Florian Albrieux Vefa Ahsen Sylvie Ducki

A phthalocyanine–chalcone conjugate has been designed to combine the vascular disrupting effect of chalcones with the photodynamic effect of phthalocyanines. This potential dual photodynamic and antiangiogenic agent was obtained by the condensation of a tetrahydroxylated non-peripherally substituted Zn(II) phthalocyanine with an amino chalcone converted into the corresponding activated isocyanate. The conjugate was fully characterized.

Chalcone

Conjugate

Isocyanate

10.1039/c2ob06809e

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Citations (26)

Synthesis and Biological Evaluation of Colchicine B-Ring Analogues Tethered with Halogenated Benzyl Moieties

Journal of Medicinal Chemistry (2012)

Laura Cosentino Mariano Redondo‐Horcajo Ying Zhao Ana Rita Santos Kaniz F. Chowdury

Deacetylcolchicine was reacted with substituted benzyl halides to provide a library of compounds for biological analysis. Compound 7 (3,4-difluorobenzyl-N-aminocolchicine) was shown to possess cytotoxicity in cancer cell lines in the low nanomolar range. Significantly, it showed no loss of activity in the resistant A2780AD ovarian carcinoma cell line known to overexpress the ABCB1 drug transporter and was also unaffected by overexpression of class III β-tubulin in HeLa transfected cells.

HeLa

Colchicine

10.1021/jm301151t

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Citations (29)

Synthesis and biological evaluation of colchicine C-ring analogues tethered with aliphatic linkers suitable for prodrug derivatisation

Bioorganic & Medicinal Chemistry Letters (2012)

Jérémie Fournier-Dit-Chabert V. Vinader Ana Rita Santos Mariano Redondo‐Horcajo Aurore Dreneau

Colchicine

Linker

HeLa

10.1016/j.bmcl.2012.09.104

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Citations (21)

Phthalocyanine-chalcone conjugates

Journal of Porphyrins and Phthalocyanines (2016)

Fallia Aribi Charlene Vey Derya Topkaya Sinem Tuncel Kostakoğlu Jérémie Fournier-Dit-Chabert

A phthalocyanine-chalcone conjugate was previously reported to retain the full photodynamic activity of the phthalocyanine and a slightly lowered antivascular effect of the chalcone. Assuming that it was due to an insufficient release of the chalcone, we described here several grafting modes applied to the preparation of phthalocyanine-chalcone conjugates.

Chalcone

Conjugate

10.1142/s1088424616500310

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Citations (9)