Nouh Saad Mohamed

National Centre for Research

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Emmanuel Edwar Siddig

University of Khartoum

Ayman Ahmed

University of Khartoum

Mohamed S. Muneer

Stanford University

Abdallah M Samy

Ain Shams University

Ali H. Mokdad

University of Washington

Stephen S Lim

Institute for Health Metrics and Evaluation

Mohamed A. Saleh

Mansoura University

Elrashdy M. Redwan

King Abdulaziz University

Omid Dadras

University of Bergen

Xiaochen Dai

University of Washington

Cooperative Institutions

Institute for Health Metrics and Evaluation

2,761

University of Washington

2,608

Tehran University of Medical Sciences

574

University of Sydney

436

University of Electronic Science and Technology of China

423

Institute for Musculoskeletal Health

307

University College London

273

Veterans Health Administration

266

Royal North Shore Hospital

220

National Health and Medical Research Council

183

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A Case Report of Membranoproliferative Glomerulonephritis: Infection‐Related or Immune‐Related?

Clinical Case Reports (2025)

Ayman Azhary Mohammed Taha Nooh Mohamed Hajhamed S A Mohammed Nouh Saad Mohamed

ABSTRACT Membranoproliferative glomerulonephritis (MPGN) has previously been used as an umbrella term to describe a spectrum of hypocomplementemic glomerular diseases, which are rare causes of end stage kidney disease (ESKD). We present a 22‐year‐old man with a well‐established medical history who had been complaining of 4 days of frothy dark urine, bilateral lower limb swelling, and puffiness on his face. For a month before his presentation, he had many bilateral skin lesions on his lower limbs that were leaking pus. Aside from the scars from the prior skin lesions, he had no other significant medical history, and his examination revealed no abnormalities. His tests revealed nephrotic range proteinuria with a normal renal profile, low serum albumin with low C3 and normal C4, and negative antinuclear antibodies (ANAs) by ELISA. After preliminary studies, we concluded that the condition was infection‐related glomerulonephritis. Nevertheless, following renal biopsy, which revealed an MPGN pattern, and immunohistochemistry, which revealed a full house picture, we conducted a second ANA test using the more sensitive/broader spectrum IFA hep2 cell test, which showed a coarse speckled nuclear pattern with a significant titer (1/1000), as well as a negative line blot assay test using 15 distinct antigens. Following the modification of our diagnosis to lupus nephritis, the patient responded fairly well once we started him on an immunosuppressive drug. The patient was released from the hospital in a stable condition.

Membranoproliferative glomerulonephritis

10.1002/ccr3.70088

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Global estimates on the number of people blind or visually impaired by age-related macular degeneration: a meta-analysis from 2000 to 2020

Eye (2024)

João M. Furtado Jost B. Jonas Ian Tapply Arthur Gustavo Fernandes Maria Vittoria Cicinelli

We aimed to update estimates of global vision loss due to age-related macular degeneration (AMD).

Degeneration (medical)

10.1038/s41433-024-03050-z

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Citations (3)

Frequency distribution of IL-17A G197A (rs2275913) and IL-17F A7488G (rs763780) polymorphisms among healthy Sudanese population

Research Square (Research Square) (2020)

Nouh Saad Mohamed Emmanuel Edwar Siddig Abdallah E. Ahmed Musab MA. Albsheer Hanadi Abdelbagi

Abstract Objectives: IL-17A G197A and IL-17F A7488G polymorphisms has been identified to be associated with the susceptibility to many diseases. This study aimed to investigate the frequency distribution of IL-17A G197A and IL-17F A7488G polymorphisms among healthy Sudanese population. A descriptive cross-sectional hospital-based molecular study conducted in different sites throughout Sudan. Two ml blood samples were collected from 717 healthy participants. Demographic data and the medical history of the participants were collected. Results: Of the 717 participants, 355 (49.5%) were males and 362 (50.5%) were females, their mean age was 30.2±17.2 and 32.2±16.5, respectively. For IL-17A , the most frequent genotype detected among males and females was IL-17A heterozygote allele (AG); 215 (60.6%) and 194 (53.6%), respectively. Whereas, for IL-17F , the most frequent allele among males and females was the homozygote allele (AA); 298 (83.9%) for males and 322 (89.0%) for females. HWE for genotype distributions of IL-17A was showing statistical insignificance for IL-17A among males and females, P value 0.614. While HWE for IL-17F reached the equilibrium level, P value 0.048. The most frequent age group was those aged between 21 to 40 years; 281 (39.2%). Arab constituted the major ethnicity of the study participants; 418 (58.3%), P value 0.034.

Genotype frequency

Population study

10.21203/rs.3.rs-31741/v2

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Eumycetoma Medical Treatment: Past, Current Practice, Latest Advances and Perspectives

Microbiology Research (2021)

Emmanuel Edwar Siddig Ayman Ahmed Yousif Ali Sahar Mubarak Bakhiet Nouh Saad Mohamed

Mycetoma is a neglected tropical disease that is associated with poor communities and socioeconomically impaired individuals in the tropical and sub-tropical areas. Interestingly, the disease is caused by either bacteria (actinomycetoma) or fungus (eumycetoma). The latter form of the disease, eumycetoma, is the most common type in Africa. Eumycetoma is characterized by a prolonged disease duration and low cure rate. The effective case management of eumycetoma largely depends on the accurate diagnosis and identification of the causative agent to the species level and evaluating its susceptibility to the available drugs. This review summarizes the currently available and used antifungal agents for the treatment of eumycetoma and discusses optimizing the newly developed antifungals as a potential second line for eumycetoma treatment.

Tropical disease

10.3390/microbiolres12040066

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Global, regional, and national age-sex-specific burden of diarrhoeal diseases, their risk factors, and aetiologies, 1990–2021, for 204 countries and territories: a systematic analysis for the Global Burden of Disease Study 2021

The Lancet Infectious Diseases (2024)

Hmwe Hmwe Kyu Avina Vongpradith Regina-Mae Villanueva Dominguez Jianing Ma Samuel B Albertson

Diarrhoeal disease

10.1016/s1473-3099(24)00691-1

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Prevalence of Helicobacter Pylori Among Sudanese Patients Diagnosed with Colon Polyps and Colon Cancer using Immunohistochemistry Technique.

Research Square (Research Square) (2020)

Aziza K. Mohamed Nazik M. Elhassan Zahra A. Awhag Fadwa S. Ali Eman T. Ali

Abstract Objectives: infection with the bacteria Helicobacter pylori has been classified as class 1 carcinogen associated with increasing susceptibility of gastritis and gastric carcinoma. This study is aiming at investigating the prevalence of H. pylori in colon polyps and colon cancer lesions. A descriptive cross-sectional hospital-based study was conducted between February and June 2017. Sixty-nine formalin fixed paraffin blocks from colon polyps and colon cancer lesions to detect H. pylori using immunohistochemistry technique. Results: Of the Sixty-nine patients included in the study, 39 (56.5%) males and 30 (43.5%) were females, their age ranged from 21 to 80 years with a mean age of 47.1 ± 19.7. Of the 69 colon polyps and colon cancer cases, 44 (63.8%) were diagnosed as adenocarcinoma, 10 (14.5%) colitis, 15 (21.7%) juvenile polyposis syndrome. The results of immunohistochemistry technique showed the presence of 16 (23.2%) positive patients for H. pylori infection. Of these 16, 13 (81.3%) patients were off those diagnosed with adenocarcinoma and the remaining 3 (18.7%) patients were diagnosed with juvenile polyps. the results of H. pylori detection among the different colon polyps and colon cancer diagnosis was showing a statistically significant association for H. pylori infection and adenocarcinoma, P value 0.028.

Hyperplastic Polyp

10.21203/rs.3.rs-31738/v1

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Global, regional, and national incidence and mortality burden of non-COVID-19 lower respiratory infections and aetiologies, 1990–2021: a systematic analysis from the Global Burden of Disease Study 2021

The Lancet Infectious Diseases (2024)

Rose G Bender Sarah Brooke Sirota Lucien R Swetschinski Regina-Mae Villanueva Dominguez Amanda Novotney

Lower respiratory infections (LRIs) are a major global contributor to morbidity and mortality. In 2020-21, non-pharmaceutical interventions associated with the COVID-19 pandemic reduced not only the transmission of SARS-CoV-2, but also the transmission of other LRI pathogens. Tracking LRI incidence and mortality, as well as the pathogens responsible, can guide health-system responses and funding priorities to reduce future burden. We present estimates from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2021 of the burden of non-COVID-19 LRIs and corresponding aetiologies from 1990 to 2021, inclusive of pandemic effects on the incidence and mortality of select respiratory viruses, globally, regionally, and for 204 countries and territories.

Pandemic

10.1016/s1473-3099(24)00176-2

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Citations (60)

Immunohistochemical expression of PAX-8 in Sudanese patients diagnosed with malignant female reproductive tract tumors

BMC Research Notes (2020)

Eman T. Ali Nouh Saad Mohamed Irene R. Shafig Mohamed S. Muneer Abubaker Ahmed Yosif

Abstract Objectives Paired box protein-8 (PAX-8) immunohistochemical expression can be used as a diagnostic marker for epithelial cells tumors. This study aimed at investigating the immunohistochemical expression of PAX-8 among Sudanese females diagnosed with cervical, endometrial, and ovarian cancers between December 2017 and May 2019 by studying their Formalin-fixed paraffin embedded blocks. Results Sixty patients diagnosed with female reproductive tract cancers were included who aged 58.7 ± 6.9 years (range, 43—71). Cervix was the most common cancer site in 51/60 (85%) patients. Regarding cancer stage, there was 17 (28%) and 14 (23%) of the study population had stage 3B and 2B, respectively. The histopathological diagnosis included 20 (44%), 13 (29%), and 12 (27%) poorly, moderately, and well differentiated cervical squamous cell carcinoma (SCC) as well as 11 (73%), 2 (13%), 1 (7%), and 1 (7%) endometrial adenocarcinoma, metastatic adenocarcinoma, endocervical adenocarcinoma, and ovarian mucinous cyst adenocarcinoma, respectively. PAX-8 was positively expressed in 9 endometrial adenocarcinoma, 1 endocervical adenocarcinoma and 1 ovarian mucinous cyst adenocarcinoma, 2 poorly, and 1 moderately differentiated SCC. All patients diagnosed with well differentiated SCC and metastatic adenocarcinoma showed no expression of PAX-8. A statistically significant was seen for PAX-8 expression and the different histopathological diagnosis, P value < 0.001.

Clear Cell Adenocarcinoma

10.1186/s13104-020-05246-4

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Citations (5)

Global incidence, prevalence, years lived with disability (YLDs), disability-adjusted life-years (DALYs), and healthy life expectancy (HALE) for 371 diseases and injuries in 204 countries and territories and 811 subnational locations, 1990–2021: a systematic analysis for the Global Burden of Disease Study 2021

The Lancet (2024)

Alize J Ferrari Damian Santomauro Amirali Aali Yohannes Habtegiorgis Abate Cristiana Abbafati

Detailed, comprehensive, and timely reporting on population health by underlying causes of disability and premature death is crucial to understanding and responding to complex patterns of disease and injury burden over time and across age groups, sexes, and locations. The availability of disease burden estimates can promote evidence-based interventions that enable public health researchers, policy makers, and other professionals to implement strategies that can mitigate diseases. It can also facilitate more rigorous monitoring of progress towards national and international health targets, such as the Sustainable Development Goals. For three decades, the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) has filled that need. A global network of collaborators contributed to the production of GBD 2021 by providing, reviewing, and analysing all available data. GBD estimates are updated routinely with additional data and refined analytical methods. GBD 2021 presents, for the first time, estimates of health loss due to the COVID-19 pandemic.

Global Health

Pandemic

10.1016/s0140-6736(24)00757-8

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Citations (724)

Complete mitogenome analysis of Fasciola gigantica from Sudan

Research Square (Research Square) (2024)

Bashir Salim Nouh Saad Mohamed Kamal A Ibrahim Saeed Alasmari Elisha Chatanga

Abstract Complete mitochondrial (mt) genomes are increasingly being used as molecular markers for investigating phylogenetic relationships. We sequenced the complete mt genome of the Fasciola gigantica of 16 samples from cattle, sheep and goats from Sudan using Illumina MiSeq platform. The complete mt genome of F. gigantica was 14,483 bp in length. Its genome is circular, and consists of 36 genes, including 12 protein-coding genes, 2 subunit ribosomal RNA genes (rRNA), and 22 genes for tRNA. The start and stop codons of the12 protein-coding genes are ATG and TAG respectively, which are identical to reference mt genomes except for the ND5 the start codon GTG and the stop codon of the ND4 which was TAA. Additionally, the lengths of the the12 protein-coding genes were identical in 10 genes, however, the ND4L of the reference was 12 bp longer with 273 bp as compared to the Sudan isolates which was 261 bp long and COX1 in the reference was 9 bp shorter which was 1,533 bp long as compared to Sudan isolates which 1,542 bp long. In contrast, the non-coding regions differed by 20 bp and 4 bp length in the long and the short non-coding regions of Sudan isolates. Nucleotide variability in the mt genome among F. gigantica from Sudan is quite different from the reference as revealed by the sliding window analysis. Phylogenetic analysis of the concatenated amino acid sequence data for all 12 protein-coding genes showed that all F. gigantica from Sudan clustered separately from the available F. gigantica . More interestingly, based on stem-loop (non-coding regions) it revealed better resolution on how the evolutionary process has affected host specificity and in particular for the sheep and goats. It is concluded that these novel complete mt genomes of F. gigantica from different host species provide additional genetic markers for studying epidemiology, population genetics, and phylogeographics of F. gigantica , as well as for understanding interplay and the host species.

Stop codon

Coding region

10.21203/rs.3.rs-3848681/v1

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