Olga Yastrubetskaya

University of Melbourne

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Co-Authors

Edmond Chiu

University of Melbourne

Nicola T. Lautenschlager

University of Melbourne

Angeline Goh

Tessa Therapeutic (Singapore)

Anita M.Y. Goh

University of Melbourne

Jane S. Paulsen

University of Wisconsin–Madison

Hans J. Johnson

University of Iowa

Anne Leserman

Huntington's Disease Society of America

Jane Griffith

Westmead Hospital

Marcy E. MacDonald

Massachusetts General Hospital

Janet K. Williams

University of Iowa

Cooperative Institutions

University of Iowa

150

University College London

125

Massachusetts General Hospital

123

Harvard University

113

University of Rochester

University of British Columbia

CHDI Foundation

University of Melbourne

Roche (Switzerland)

Columbia University

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Assessing speech and communication impairments in cognitive disorders: an innovative development in a memory clinic

International Psychogeriatrics (2009)

Ian Thompson Olga Yastrubetskaya Nicola T. Lautenschlager David Ames Edmond Chiu

Although there is a great emphasis on memory in the diagnosis of dementia and in the measurement of treatment response, disorders of language are an important, but sometimes neglected, feature of many dementias.

Feature (linguistics)

10.1017/s1041610209991037

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Citations (4)

Studies of Aggressive Behaviour in Schizophrenia: Is There a Response Bias?

Medicine Science and the Law (1997)

Peter Cheung Isaac Schweitzer Olga Yastrubetskaya Kathleen Crowley Virginia Tuckwell

Of 73 patients who met selection criteria to enter into a study on aggressive behaviour in schizophrenia, 11 patients (15.1%) did not participate. The participants and non-participants were similar in age, gender ratio and proportion who had aggressive behaviour. The participants, however, had a longer duration of illness, a longer duration of current admission, were more likely to suffer from residual schizophrenia, but less likely to suffer from disorganized schizophrenia and were less severely ill than the non-participants. These results indicate the need, in studies of aggressive behaviour in schizophrenia, to consider non-response bias as a confounding variable.

10.1177/002580249703700411

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Citations (10)

Aggressive behaviour and extrapyramidal side effects of neuroleptics in schizophrenia

International Clinical Psychopharmacology (1996)

Raymond Cheung I. Schweitzer Kathleen Crowley Olga Yastrubetskaya Virginia Tuckwell

The objective of this study was So determine whether extrapyramidal side effects of neuroleptics are associated with aggressive behaviour in schizophrenia. Thirty-one physically aggressive patients meeting DSM-III-R criteria for schizophrenia were compared with 31 matched non-aggressive patients in relation to their extrapvramidal side effects, including drug-induced parkinsonian (DIP) symptoms, akathisia and tardive dyskinesia. The aggressive group had significantly more severe DIP side effects than the non-aggressive group, but the association disappeared when level of psychopathology was controlled for. The aggressive group had more severe akathisia than the non-aggressive group, but the difference was not statistically significant. The two groups did not differ in the severity of tardive dyskinesia. There was no significant, independent effect of extrapyramidal symptoms on aggressive behaviour in our sample of schizophrenic patients.

Akathisia

Tardive dyskinesia

Extrapyramidal symptoms

10.1097/00004850-199612000-00004

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Citations (13)

Quantitative motor assessment in patients with mild to moderate Alzheimer's disease (AD)

International Psychogeriatrics (2011)

Nicola T. Lautenschlager Angeline Goh E. Chiu Olga Yastrubetskaya Ralf Reilmann

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Recruitment and Retention Strategies for PREDICT-HD Study at HSG Site 144

Neurotherapeutics (2008)

Olga Yastrubetskaya J. Samuel Preston E. Chiu

10.1016/j.nurt.2007.10.015

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Citations (0)

Third Annual Huntington Disease Clinical Research Symposium

Neurotherapeutics (2010)

Richard Dubinsky Judy Roberson G. Battaglia Milena Cannella B. Riozzi

10.1007/bf03215660

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Citations (0)

Stronger effect of amyloid load than APOE genotype on cognitive decline in healthy older adults

Neurology (2012)

Yen Ying Lim Kathryn A. Ellis Robert H. Pietrzak David Ames David Darby

Objective:

Although the APOE ϵ4 allele is associated with more rapid decline in memory in healthy older adults, the significance of elevated cerebral β-amyloid (Aβ) load for longitudinal changes in cognition is unclear.

Methods:

Healthy and cognitively normal older adults (n = 141; mean age 76 years) underwent PET neuroimaging for cerebral Aβ, APOE genotyping, and cognitive assessment as part of their baseline assessment in the Australian Imaging Biomarkers and Lifestyle study. Cognitive function was reassessed 18 months later.

Results:

Linear mixed-model analyses adjusted for baseline cognitive function indicated that, relative to individuals with low cerebral Aβ, individuals with high cerebral Aβ showed significantly greater decline in working memory and verbal and visual episodic memory at 18 months. Compared with noncarriers, APOE ϵ4 carriers showed a greater decline in visual memory at the 18-month assessment. No interaction between APOE ϵ4 and cerebral Aβ load was observed for any measure of cognitive function.

Conclusions:

In this prospective study of healthy older adults, high cerebral Aβ load was associated with greater decline in episodic and working memory over 18 months. The APOE ϵ4 genotype was also associated with a decline in visual memory, although the effect was less than that observed for cerebral Aβ load.

Cognitive Decline

Apolipoprotein E

Longitudinal Study

10.1212/wnl.0b013e31826e9ae6

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Citations (102)

What's the future of treatment for Alzheimer's disease?

Medicine today (2010)

Cassandra Szoeke Sarah Campbell Nicola T. Lautenschlager Olga Yastrubetskaya D Ames

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Citations (0)

Poster 2: Genetic Discrimination of Individuals at Risk of Huntington's Disease: Further Analysis of the RESPOND-HD Data From Australia (Site 144)

Neurotherapeutics (2010)

Angeline Goh Olga Yastrubetskaya Edmond Chiu

Complaint

Genetic discrimination

Human services

10.1016/j.nurt.2009.09.003

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Citations (1)

Psychosocial rehabilitation of the elderly with mental disorders: a neglected area in the psychiatry of old age

Current Opinion in Psychiatry (1999)

Edmond Chiu Olga Yastrubetskaya Monica Williams

Academic Unit for Psychiatry of Old Age, The University of Melbourne, St George's Health Service, Kew, Victoria, Australia Correspondence to Edmond Chiu, Academic Unit for Psychiatry of Old Age, The University of Melbourne, St George's Health Service, 283 Cotham Road, Kew, Victoria, Australia

George (robot)

10.1097/00001504-199907000-00011

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Citations (5)