Juan José Rosales

Universidad Nacional del Centro de la Provincia de Buenos Aires

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Ángela Bronte Viedma

Hospital Universitario Son Espases

María José García-Velloso

Clinica Universidad de Navarra

Juan Fernando Bastidas

Edwards Comprehensive Cancer Center

Macarena Rodríguez‐Fraile

Clinica Universidad de Navarra

Javier Arbizu

Clinica Universidad de Navarra

Maia Marín

Fundación Ciencias Exactas y Naturales

Sandra Pérez

Universidad Nacional del Centro de la Provincia de Buenos Aires

Lidia Sancho

Clinica Universidad de Navarra

Elena Prieto

Clinica Universidad de Navarra

Gemma Quincoces

Clinica Universidad de Navarra

Cooperative Institutions

Clinica Universidad de Navarra

Universidad de Navarra

Navarre Institute of Health Research

Mexican Social Security Institute

Heidelberg University

Centro Medico Nacional Siglo XXI

Instituto de Salud Carlos III

Consejo Nacional de Investigaciones Científicas y Técnicas

University Hospital Heidelberg

Centro de Investigación Biomédica en Red de Cáncer

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68Ga-PSMA-11 PET/CT in Cherry Hemangiomas

Clinical Nuclear Medicine (2024)

Vicky Betech-Antar César Urtasun-Iriarte Juan José Rosales Miguel Barrio-Piqueras Macarena Rodríguez‐Fraile

Abstract A 63-year-old man was remitted for a 68 Ga-PSMA-11 PET/CT scan due to biochemical recurrence with a PSA of 0.32 ng/mL 1 year after radical prostatectomy of locally advanced Gleason 6 (3 + 3) ISUP 2 pT3a pN0 prostate cancer. 68 Ga-PSMA-11 PET/CT showed multiple cutaneous and subcutaneous uptake foci in the upper body. Physical examination revealed numerous dome-shaped, ruby-red papules. These were consistent with a previous diagnosis of cutaneous hemangiomas. Cherry hemangiomas (also known as Campbell de Morgan spots) are the most common type of benign vascular proliferation of the skin. Due to the nonspecific 68 Ga-PSMA-11 uptake of vascular lesions, careful interpretation should be considered in order to avoid a potential pitfall in nonmalignant conditions.

10.1097/rlu.0000000000005277

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Biphasic modulation of the TLR7 signaling pathway in bovine alphaherpesvirus (BoAHV) infection of neural cells

Veterinary Microbiology (2025)

Juan José Rosales Monika C. Brunner‐Weinzierl Maia Marín Sandra Pérez

TLR7

Imiquimod

10.1016/j.vetmic.2025.110424

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CO021 - PREPARACIÓN, DOBLE RADIOMARCAJE DE NP DE HSA CON TECNECIO-99M Y GALIO-67 Y ESTUDIOS DE BIODISTRIBUCIÓN IN VIVO MEDIANTE MICROSPECT/CT PARA ACELERAR SU DESARROLLO FARMACÉUTICO COMO NANOVACUNAS

Revista Española de Medicina Nuclear e Imagen Molecular (2023)

Félix Pareja Elke van Brandwijk Jon Ander Simón Ángela Bronte Viedma Juan José Rosales

10.1016/s2253-654x(23)00288-3

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Qualitative and quantitative assesment of xBone and xQuant, the most novel SPECT-CT reconstruction methods.

Journal of Nuclear Medicine (2019)

Edgar F. Guillén Lidia Sancho Verónica Morán Juan Fernando Bastidas Juan José Rosales

1289 Objectives: Firstly, the comparison of quantitative values between the new reconstruction algorithms, xSPECT Bone (xB) and xSPECT Quant (xQ), in a group of patients. Secondly, image quality qualitative assessment in a subset of patients, comparing the new reconstruction algorithms with the classic Flash3D method. Methods: 48 patients referred for a bone scintigraphy due to musculoskeletal, oncological and internal medicine pathologies were assessed using a Symbia IntevoBold SPECT-CT (Siemens). Images were reconstructed using the ordered subset conjugate gradient maximization algorithm, xB and xQ, selecting for each of them the reconstruction predefined by the manufacturer, best and the standard. SUVmax and SUVmean values were measured in pathological uptake regions as well as in healthy bone, subsequently comparing the variability between the measurements (ANOVA). In a subset of 6 patients, a double acquisition protocol, Flash3D and xSPECT, was performed with the obtention of 6 reconstructions: corrected and uncorrected Flash3D, best and standard xB and best and standard xQ. Five specialists in nuclear medicine evaluated the reconstructions quality using a 4 categories scale (excellent, good, poor, not interpretable). Results: There were no significant differences among SUVmean values when comparing the measurements performed in healthy bone: xB-Best vs. xB-Standar, xQ-Best vs. xQ-Standar, xB-Best vs. xQ-Best, xB-Standar vs. xQ-Standard. In the pathological uptake regions, SUVmean behavior was more heterogeneous, as there were no significant differences among the groups xB-Best vs. xQ-Best, xB-Best vs. xQ-Standard, xB-Standard vs. xQ-Standard, xQ-Best vs. xQ-Standard.SUVmax values showed statistically significant differences between the different reconstructions (p <0.001), except for the reconstructions xQ-Best vs. xQ-Standard, in the pathological uptake regions as well as in healthy tissue.In the qualitative assessment, xB-Best and standard reconstructions were considered in most cases of excellent visual quality (73.3% and 90% respectively), whereas xQ-Best and standard were rated as good quality (93,3% and 73.3% respectively). However, Flash3D was considered poor in 86.7% of corrected reconstructions, in the 66.7% of uncorrected ones and not interpretable in 26.7%. Conclusions: Regarding quantitative values, SUVmax showed statistically significant differences when comparing different reconstructions. However, SUVmean values appear to be more stable.With reference to image quality, it is better in the xB reconstruction than in xQ or Flash3D and there were no large differences when comparing the reconstructions xB-Best Vs. xB-standard and xQ Vs. Flash3D.

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Clinical Nuclear Medicine in Neurology

Springer eBooks (2021)

Andrea Varrone Silvia Morbelli Valentina Garibotto Maria Isabella Donegani María Isabel Vargas

10.1007/978-3-030-83598-9

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Diagnosis of giant cell arteritis by 18F-FDG PET/CT in patients on glucocorticoid therapy: importance of delayed imaging

Clinical and Experimental Rheumatology (2024)

Vicente Aldasoro Vicky Betech-Antar Santos Castañeda Eugenio de Miguel Juan José Rosales

Arteritis

10.55563/clinexprheumatol/db8p4e

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Estado del arte y perspectivas futuras de nuevos radionúclidos en Medicina Nuclear. Parte I

Revista Española de Medicina Nuclear e Imagen Molecular (2025)

Juan José Rosales M.L. Domínguez Luis Sancho Elena Prieto M. de Arcocha

10.1016/j.remn.2024.500082

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Pulmonary Artery Sarcoma With Low 18F-FDG Uptake

Clinical Nuclear Medicine (2020)

Juan José Rosales Laura García Juan Fernando Bastidas Ángela Bronte Viedma María José García-Velloso

A 75-year-old man presented with dyspnea for more than 2 months, with blood test showing low platelet count and cardiac ultrasound showing severe pulmonary hypertension (>54 mm Hg). A CT pulmonary angiogram showed a filling defect in the pulmonary trunk, right and left pulmonary arteries, raising the possibilities of pulmonary embolism or artery sarcoma. FDG PET/CT was performed for further evaluation and showed low uptake in the pulmonary wall, which supported the diagnosis of pulmonary embolism. Patient was treated with anticoagulants with no changes on repeated CT pulmonary angiogram. Patient underwent surgery, and histopatological examination revealed a pulmonary artery sarcoma.

10.1097/rlu.0000000000003376

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Variación de la circulación enterohepática a través de la imagen con 75SeHCAT en las 3 primeras horas. Patrones gammagráficos y análisis de su asociación con el diagnóstico de malabsorción de ácidos biliares

Revista Española de Medicina Nuclear e Imagen Molecular (2021)

Ángela Bronte Viedma Juan Fernando Bastidas Juan José Rosales J. Zuaznabar Maite Herráiz

Enterohepatic circulation

10.1016/j.remn.2021.01.006

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Infection by bovine alphaherpesvirus types 1 and 5 induces IFN-λ3 expression in neuronal-type cells and bovine neural tissues

Veterinary Immunology and Immunopathology (2022)

Juan José Rosales Maria Vicoria Nieto Farías Mercedes Burucúa Maia Marín Sandra Pérez

10.1016/j.vetimm.2022.110391

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