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Matloob Ahmad

Government College University, Faisalabad

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Sana Aslam

Abbasi Shaheed Hospital

Hamid Latif Siddiqui

University of the Punjab

Masood Parvez

Ibrahim Cardiac Hospital & Research Institute

Ameer Fawad Zahoor

Government College University, Faisalabad

Asim Mansha

Government College University, Faisalabad

Syed Ali Raza Naqvi

Government College University, Faisalabad

Usman Ali Ashfaq

Government College University, Faisalabad

Magdi E. A. Zaki

Imam Mohammad ibn Saud Islamic University

Sadia Sultan

Universiti Teknologi MARA

Furqan Ahmad Saddique

Government College University, Faisalabad

Cooperative Institutions

Government College University, Faisalabad

University of the Punjab

University of Faisalabad

University of Agriculture Faisalabad

COMSATS University Islamabad

Islamia University of Bahawalpur

Government College University, Lahore

University of Sargodha

University of Lahore

Quaid-i-Azam University

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Pharmacological and toxicological evaluation of methyl 4-hydroxy-2H-1,2-benzothiazine-3-carboxylate 1,1-dioxoide against haloperidol induced Parkinson like symptoms in animal model: In-vitro and in-vivo studies

Toxicology and Applied Pharmacology (2023)

Liaqat Hussain Ina Masood Matloob Ahmad Muhammad Yasir Ali Uzma Saleem

10.1016/j.taap.2023.116678

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Recent developments of quinoline based antimalarial agents

Afinidad (2017)

H. Mariam Manzoor Matloob Ahmad Furqan Ahmad Saddique Sana Aslam Salsabillah Khan

espanolLa malaria es una enfermedad conocida en todo el mundo que puede causar la muerte. Por el momento se han sintetizado una serie de compuestos antimalaricos a base de quinolina tras la sintesis de la quinina. Esta revision ha abarcado una serie diversificada de derivados de quinolina que se han presentado en estos ultimos cinco anos, y destaca su importancia como agentes antimalaricos. catalaLa malaria es una infermetat coneguda arreu del mon que pot causar la mort. Fins al moment s’han sintetitzat una serie de compostos antimalarics a base de quinolina despres de la sintesi de la quinina. Aquesta revisio ha tractat una serie amplia de derivats de quinolina que s’han presentat en aquests darrers cinc anys, i ressalta la seva importancia com agents antimalarics. EnglishMalaria is a well known death causing disease worldwide. A number of quinoline based antimalarial compounds have been synthesized up till now after the discovery of antimalarial character of quinine. This review covered a diversified quinoline derivatives presented during the last five years, thus highlighting their importance as antimalarial agents.

Quinoline

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A Comprehensive Update of Anti-COVID-19 Activity of Heterocyclic Compounds

Drug Design Development and Therapy (2024)

M. Tariq Nazir Matloob Ahmad Sana Aslam Ayesha Rafiq Sami A. Al‐Hussain

Abstract: The Coronavirus disease 2019 (COVID-19) pandemic is one of the most considerable health problems across the world. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the major causative agent of COVID-19. The severe symptoms of this deadly disease include shortness of breath, fever, cough, loss of smell, and a broad spectrum of other health issues such as diarrhea, pneumonia, bronchitis, septic shock, and multiple organ failure. Currently, there are no medications available for coronavirus patients, except symptom-relieving drugs. Therefore, SARS-CoV-2 requires the development of effective drugs and specific treatments. Heterocycles are important constituents of more than 85% of the physiologically active pharmaceutical drugs on the market now. Several FDA-approved drugs have been reported including molnupiravir, remdesivir, ritonavir, oseltamivir, favipiravir, chloroquine, and hydroxychloroquine for the cure of COVID-19. In this study, we discuss potent anti-SARS-CoV-2 heterocyclic compounds that have been synthesized over the past few years. These compounds included; indole, piperidine, pyrazine, pyrimidine, pyrrole, piperazine, quinazoline, oxazole, quinoline, isoxazole, thiazole, quinoxaline, pyrazole, azafluorene, imidazole, thiadiazole, triazole, coumarin, chromene, and benzodioxole. Both in vitro and in silico studies were performed to determine the potential of these heterocyclic compounds in the fight against various SARS-CoV-2 proteins. Keywords: COVID-19, SARS-CoV-2, heterocyclic nucleus, in vitro, in silico, molecular docking studies

2019-20 coronavirus outbreak

10.2147/dddt.s450499

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Synthesis, X-ray crystal and monoamine oxidase inhibitory activity of 4,6-dihydrobenzo[c]pyrano[2,3-e][1,2]thiazine 5,5-dioxides: In vitro studies and docking analysis

European Journal of Pharmaceutical Sciences (2019)

Shakeel Ahmad Saquib Jalil Sumera Zaib Sana Aslam Matloob Ahmad

Sodium hydride

Thiazine

Docking (animal)

Monoamine oxidase B

Lactam

10.1016/j.ejps.2019.02.007

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Climatological and social fallacies about COVID-19 pandemic

Environmental Sustainability (2021)

Ambar Farooq Uttam Kumar Junaite Bin Gais Uddin Muhammad Haroon U. Rashid Matoor Mohsin Gilani

Coronavirus disease (COVID-19) has emerged as a major global challenge since 2019. With the fast rise in the infected cases and deaths worldwide, many environmental and climate-related myths and fallacies spreaded fast. These fallacies include virus cannot spread in hot and humid conditions, cold weather can inhibit the virus, drinking hot water and sunlight can help cure the COVID-19, ultraviolet (UV) disinfectant lamps and UV rays from sunlight can kill the virus, use of hairdryers and hot showers for virus prevention, etc. Social norms and mindset of the people in the world towards a pandemic are quite similar. The primary purpose of this article is to enlighten the readers regarding these climatological misconceptions and social fallacies, helping spread proper knowledge and manage the outbreak of this deadly pandemic.

Pandemic

Mindset

Sunlight

2019-20 coronavirus outbreak

10.1007/s42398-021-00175-9

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Design, synthesis, in-silico study and anticancer potential of novel n-4- piperazinyl-ciprofloxacin-aniline hybrids.

Rabia Akhtar Ameer Fawad Zahoor Azhar Rasul Matloob Ahmad Muhammad Naveed Anjum

Synthesis and characterization of novel structural hybrids of ciprofloxacin linked with a variety of anilides have been described in this paper. Antitumor activity of these derivatives was assessed against liver cell line (Huh-7) using MTT assay. Among the synthesized derivatives, compound 6a inhibited the growth of tumor cells by displaying 68.36% cell viability at 100 μg/mL concentration which was then in-silico modelled to delineate the potential mechanistic insights for its antiproliferative activity. The PASS prediction indicated the TopII as potential anticancer target of compound 6a. The induced fit docking revealed that compound 6a inhibits the TopII with superior binding affinity and forms stronger contacts with active site's key residues responsible for DNA-TopII intercalation and catalytic inhibition consistent with its cytotoxic potential. Therefore, compound 6a can be considered as a potential lead for further optimization in the development of ciprofloxacin-derived anticancer drugs.

Docking (animal)

Lead compound

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N-Arylpyrazole based Scaffolds: Synthesis and biological applications

Journal of Saudi Chemical Society (2024)

Sumayya Akram Tooba Jabeen Sana Aslam Amnah Yusaf Matloob Ahmad

N-aryl pyrazoles are important building blocks in many biologically active compounds, natural products, pharmaceuticals, and industries. It is an important moiety of various drugs and exhibits extensive biological activities viz., antibiotic, anticancer, antifungal, anti-inflammatory, anti-coagulant, analgesic, antipyretic, anti-depressant, insecticidal, and hyperglycemic activities. Various protocols have been designed for the synthesis of N-aryl pyrazoles facilitated by a wide variety of metal-based catalysts at high or room temperature, metal free reactions, various named reactions, multicomponent reactions, and those occurring under different electromagnetic radiations. Various ligands are found to promote Cu-catalyzed N-arylation of pyrazole under mild conditions in short time. This review describes the synthesis and biological applications of N-aryl pyrazole derivatives reported during 2019–2023.

Moiety

Pyrazole

Antipyretic

10.1016/j.jscs.2024.101861

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Enhanced solubilization and encapsulation of direct dyes through self-assembled single and mixed micellar nanocarriers

Environmental Technology & Innovation (2023)

Saira Irshad Hamadia Sultana Muhammad Usman Matloob Ahmad Sami A. Al‐Hussain

This manuscript provides insights into the solubilization of two direct dyes, direct green 6 (DG-6) and direct yellow 44 (DY-44), in different surfactant systems. It reports the interaction and applicability of surfactants to elevate the solubility of direct dyes in aqueous medium. Different combinations of cationic (cetyltrimethylammonium bromide) and nonionic surfactants (Triton X-100, Tween-20) have been employed for said purpose. Inclusion of nonionic surfactants to micellar media of ionic ones enhances space within micelle to accommodate more solubilizate within it. Conductometric and spectroscopic measurements were applied for investigating the interaction of dyes in these surfactant solutions. The properties of surfactants, their behavior in aqueous systems, and thermodynamics have been evaluated in terms of critical micelle concentration (CMC), and change in Gibbs energy (ΔGm), enthalpy (ΔHm), and entropy (ΔSm) of micellization. While the solubilization capability of different surfactant systems was explored with the help of binding (ΔKb) and partition (ΔKx) parameters. Moreover, the stability of the process has been revealed by calculating the Gibbs energies of binding (ΔGb) and partition (ΔGp). The results revealed that mixed surfactants are more suitable agents for the solubilization of dyes. It was also observed that the partition of dye molecules is greatly dependent on their interaction with the surfactant molecules. This study will provide the basis for choosing the suitable surfactant system to be used in various surfactant-based dye removal techniques.

Cationic polymerization

Micellar solutions

Microemulsion

10.1016/j.eti.2023.103061

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Citations (7)

SA202 Insert Bearing with Eccentric Locking Collar

Applied Biochemistry and Biotechnology (2018)

Anam Iqbal Syed Ali Raza Naqvi Rashid Rasheed Asim Mansha Matloob Ahmad

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Synthesis, spectral analysis and biological evaluation of 2-{[(morpholin-4-yl)ethyl]thio}-5-phenyl/aryl-1,3,4-oxadiazole derivatives.

Pakistan Journal of Pharmaceutical Sciences (2021)

Azizur Rehman Samreen Gul Khan Syed Ali Raza Naqvi Matloob Ahmad Naheed Akhtar

A series of new derivatives of 4-(2-chloroethyl)morpholine hydrochloride (5) were efficiently synthesized. Briefly, different aromatic organic acids (1a-f) were refluxed to acquire respective esters (2a-f) using conc. H2SO4 as catalyst. The esters were subjected to nucleophillic substitution by monohydrated hydrazine to acquire hydrazides (3a-f). The hydrazides were cyclized with CS2 in the presence of KOH to yield corresponding oxadiazoles (4a-f). Finally, the derivatives, 6a-f, were prepared by reacting oxadiazoles (4a-f) with 5 using NaH as activator. Structures of all the derivatives were elucidated through 1D-NMR EI-MS and IR spectral data. All these molecules were subjected to antibacterial and hemolytic activities and showed good antibacterial and hemolytic potential relative to the reference standards.

Morpholine

Hydrazine (antidepressant)

Thio-

Hydrochloride

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