Karen Middelbo Buch‐Olsen

University of Southern Denmark

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Paw Christian Holdgaard

Lillebaelt Hospital

Jorun Holm

Odense University Hospital

Oke Gerke

Odense University Hospital

Malene Grubbe Hildebrandt

Odense University Hospital

Jane Angel Simonsen

Odense University Hospital

Søren Hess

Odense University Hospital

Poul Flemming Høilund‐Carlsen

Odense University Hospital

Poul‐Erik Braad

Odense University Hospital

Kasper Pedersen

Odense University Hospital

Mads Hvid Poulsen

Odense University Hospital

Cooperative Institutions

Odense University Hospital

University of Southern Denmark

Klinik und Poliklinik für Nuklearmedizin

University of Copenhagen

Copenhagen University Hospital

Aarhus University Hospital

Rigshospitalet

Lillebaelt Hospital

Vejle Sygehus

Aarhus University

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18F-FDG-PET/CT in fever of unknown origin

Nuclear Medicine Communications (2014)

Karen Middelbo Buch‐Olsen Rikke V. Andersen Søren Hess Poul‐Erik Braad Søren Schifter

Fever of unknown origin continues to be a diagnostic challenge for clinicians. The aim of this study was to confirm whether (18)F-fluorodeoxyglucose ((18)F-FDG)-PET/computed tomography (CT) is a helpful tool in patients suffering from this condition.Fifty-seven patients with fever of unknown origin were examined with (18)F-FDG-PET/CT as part of their diagnostic workup at the clinicians' discretion. The medical records were read retrospectively to establish the final diagnosis and evaluate the degree to which PET/CT contributed to the diagnosis.The examination was considered helpful if it corresponded to the final diagnosis by showing uptake in an organ considered responsible for the condition, or if it was without focal findings, thereby excluding the patient from having focal infection or malignancy. It was perceived false positive if it pointed towards an organ not regarded by the clinicians as being related to the final diagnosis. It was perceived not helpful if the cause of fever was not visible on (18)F-FDG-PET/CT. We found (18)F-FDG-PET/CT helpful in 75% of patients, not helpful in 4%, and false positive in 21% of patients.(18)F-FDG-PET/CT is a useful tool in the investigation of fever of unknown origin; it can reduce patient inconvenience and possibly costs to society if used earlier in the diagnostic process.

Medical record

10.1097/mnm.0000000000000146

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Citations (35)

A randomised trial of [¹⁸F]PSMA‐1007‐PET/CT versus NaF‐PET/CT for staging primary prostate cancer: A trial protocol

BJUI Compass (2023)

Karen Middelbo Buch‐Olsen Mads Hvid Poulsen Steinbjørn Hansen Mie Holm Vilstrup Jorun Holm

Prostate-specific membrane antigen (PSMA)-positron emission tomography/contrast-enhanced computed tomography (PET/CT) is a sensitive imaging modality for prostate cancer (PCa). Due to lack of knowledge of the patient benefit, PSMA-PET/CT is not yet recommended in the European guidelines for staging and treatment planning of patients with newly diagnosed PCa. We will investigate the potential difference in progression-free survival (PFS) and quality of life (QoL) of using PSMA-PET/CT versus sodium fluoride (NaF)-PET/CT for staging and treatment planning in patients with newly diagnosed PCa.

Clinical endpoint

PET-CT

10.1002/bco2.243

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Citations (2)

[Fever of unknown origin diagnosed with FDG-PET/CT].

PubMed (2014)

Karen Middelbo Buch‐Olsen Paw Christian Holdgaard

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Prostate cancer metastasis mimicking appendicitis—A rare but important differential diagnosis in PET/CT imaging

Radiology Case Reports (2022)

Johanne Kühl Karen Middelbo Buch‐Olsen Mohammad Talal Elhakim

Prostate cancer most commonly metastasizes to lymph nodes, bones, the liver, and the lungs. Prostate cancer carcinomatosis with an affinity for the appendix is not well described in current literature and is usually reported with acute appendicitis as the primary presentation. A 65-year-old male with a history of recurrent prostate cancer presented with an increase in PSA value. 18F-PSMA-1007 PET/CT showed nodular tissue growth and increased PSMA uptake in the prostate, on the appendix, in the umbilicus, and in several intra- and extra pelvic lymph nodes. The patient had no symptomatic complaints at time of referral. Imaging findings of the appendix resembling characteristic findings of acute appendicitis raised doubts about the interpretation of these as inflammatory disease or peritoneal carcinomatosis secondary to prostate cancer. This case demonstrates the importance of correct differentiation between the 2 conditions based on imaging, clinical symptomatology, and patient history to provide proper care in time.

PET-CT

10.1016/j.radcr.2022.10.024

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Feber af ukendt årsag afklaret med FDG-PET/CT

Ugeskrift for Læger (2014)

Karen Middelbo Buch‐Olsen Paw Christian Holdgaard

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Automated quantification of PET/CT skeletal tumor burden in prostate cancer using artificial intelligence: The PET index

European Journal of Nuclear Medicine and Molecular Imaging (2023)

Sarah Lindgren Belal Måns Larsson Jorun Holm Karen Middelbo Buch‐Olsen Jens Sörensen

Consistent assessment of bone metastases is crucial for patient management and clinical trials in prostate cancer (PCa). We aimed to develop a fully automated convolutional neural network (CNN)-based model for calculating PET/CT skeletal tumor burden in patients with PCa.A total of 168 patients from three centers were divided into training, validation, and test groups. Manual annotations of skeletal lesions in [18F]fluoride PET/CT scans were used to train a CNN. The AI model was evaluated in 26 patients and compared to segmentations by physicians and to a SUV 15 threshold. PET index representing the percentage of skeletal volume taken up by lesions was estimated.There was no case in which all readers agreed on prevalence of lesions that the AI model failed to detect. PET index by the AI model correlated moderately strong to physician PET index (mean r = 0.69). Threshold PET index correlated fairly with physician PET index (mean r = 0.49). The sensitivity for lesion detection was 65-76% for AI, 68-91% for physicians, and 44-51% for threshold depending on which physician was considered reference.It was possible to develop an AI-based model for automated assessment of PET/CT skeletal tumor burden. The model's performance was superior to using a threshold and provides fully automated calculation of whole-body skeletal tumor burden. It could be further developed to apply to different radiotracers. Objective scan evaluation is a first step toward developing a PET/CT imaging biomarker for PCa skeletal metastases.

PET-CT

10.1007/s00259-023-06108-4

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Citations (8)

Intra- and interobserver error of the Greulich–Pyle method as used on a Danish forensic sample

Forensic Science International (2008)

Niels Lynnerup Erika Bélard Karen Middelbo Buch‐Olsen Birgitte Sejrsen Karen Damgaard-Pedersen

Danish

Forensic dentistry

10.1016/j.forsciint.2008.05.005

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Citations (62)

Delayed 18F-fluorodeoxyglucose PET/CT imaging improves quantitation of atherosclerotic plaque inflammation: Results from the CAMONA study

Journal of Nuclear Cardiology (2014)

Björn A. Blomberg Anders Thomassen Richard A. P. Takx Malene Grubbe Hildebrandt Jane Angel Simonsen

Fluorodeoxyglucose

Standardized uptake value

10.1007/s12350-014-9884-6

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Citations (80)

Indications for nuclear medicine imaging in prostate cancer

Ugeskrift for Læger (2024)

Andreas Underbjerg Raade Karen Middelbo Buch‐Olsen Lars Christian Lund Helle D. Zacho Michael Borre

Nuclear medicine imaging for prostate cancer has advanced significantly over the past decade. A survey is presented in this review. PSMA-PET/CT is a new highly accurate method that has been introduced, but bone scans and bone-PET continue to be widely applied. PSMA-PET/CT still lacks sufficient patient outcome data to be recommended for treatment allocation when used for primary staging. However, the literature and clinical guidelines support its use at the stage of biochemical recurrence. In Denmark, the use of nuclear medicine examinations for prostate cancer aligns with clinical guideline recommendations.

Guideline

10.61409/v01240036

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Extra skeletal incidental findings on CT part of NaF PET/CT in evaluation of prostate cancer

H.J. Nissen Jeppe F. Lauridsen Paw Christian Holdgaard P. Dolliner V. Ovchinnikova

PET-CT

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