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Valentina Svicher

University of Rome Tor Vergata

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Carlo Federico Perno

Bambino Gesù Children's Hospital

Romina Salpini

University of Rome Tor Vergata

Francesca Ceccherini‐Silberstein

University of Rome Tor Vergata

Massimo Andreoni

University of Rome Tor Vergata

Loredana Sarmati

University of Rome Tor Vergata

Ada Bertoli

University of Rome Tor Vergata

Lorenzo Piermatteo

University of Rome Tor Vergata

Vincenzo Malagnino

University of Rome Tor Vergata

M. Angélico

Policlinico Tor Vergata

Claudia Alteri

University of Milan

Cooperative Institutions

University of Rome Tor Vergata

Istituti di Ricovero e Cura a Carattere Scientifico

University of Milan

Regione Puglia

Istituto Nazionale per le Malattie Infettive Lazzaro Spallanzani

Sapienza University of Rome

Policlinico Tor Vergata

Indian Council of Agricultural Research

Luigi Sacco Hospital

University of Padua

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Recommendations for screening, monitoring, prevention, prophylaxis and therapy of hepatitis B virus reactivation in patients with haematologic malignancies and patients who underwent haematologic stem cell transplantation—a position paper

Clinical Microbiology and Infection (2017)

Loredana Sarmati Massimo Andreoni Guido Antonelli William Arcese Raffaele Bruno

Hepatitis B

10.1016/j.cmi.2017.06.023

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Citations (77)

Characterization of Novel HIV Drug Resistance Mutations Using Clustering, Multidimensional Scaling and SVM-Based Feature Ranking

Lecture notes in computer science (2005)

Tobias Sing Valentina Svicher Niko Beerenwinkel Francesca Ceccherini‐Silberstein Martin Däumer

Feature (linguistics)

10.1007/11564126_30

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Citations (37)

1025 THE GENETIC BARRIER MODULATES THE IMMUNE ESCAPE POTENTIAL OF HBV GENOTYPES

Journal of Hepatology (2010)

Valentina Svicher Valeria Cento Romina Salpini F. Merucurio Yongchao Han

Immune escape

10.1016/s0168-8278(10)61026-4

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Effects of Amprenavir on HIV-1 Maturation, Production and Infectivity Following Drug Withdrawal in Chronically-Infected Monocytes/Macrophages

Ana Borrajo Alessandro Ranazzi Michela Pollicita Roberto Bruno Andrea Modesti

A paucity of information is available on the activity of protease inhibitors (PI) in chronically-infected monocyte-derived macrophages (MDM) and on the kinetics of viral-rebound after PI removal in vitro. To fill this gap, the activity of different concentrations of amprenavir (AMP) was evaluated in chronically-infected MDM by measuring p24-production every day up to 12 days after drug administration and up to seven days after drug removal. Clinically-relevant concentrations of AMP (4 and 20 μM) drastically decreased p24 amount released from chronically-infected MDM from Day 2 up to Day 12 after drug administration. The kinetics of viral-rebound after AMP-removal (4 and 20 μM) showed that, despite an initial increase, p24-production over time never reached the level observed for untreated-MDM, suggesting a persistent intracellular drug activity. In line with this, after AMP-removal, human immunodeficiency virus 1 (HIV-1) infectivity and intracellular the p24/p55 ratio (reflecting virion-maturation) were remarkably lower than observed for untreated MDM. Overall, AMP shows high efficacy in blocking HIV-1 replication in chronically-infected MDM, persisting even after drug-removal. This highlights the role of protease inhibitors in preventing the establishment of this important HIV-1 reservoir, thus reducing viral-dissemination in different anatomical compartments.

Amprenavir

Infectivity

Monocyte

Protease inhibitor (pharmacology)

10.3390/v9100277

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Citations (12)

The novel HBx mutation F30V correlates with hepatocellular carcinoma in vivo, reduces hepatitis B virus replicative efficiency and enhances anti-apoptotic activity of HBx N terminus in vitro

Clinical Microbiology and Infection (2018)

Romina Salpini Matteo Surdo María Francesca Cortese G.A. Palumbo Luca Carioti

HBx

cccDNA

10.1016/j.cmi.2018.11.017

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Citations (15)

Effect of maraviroc on non-R5 tropic HIV-1: refined analysis of subjects from the phase IIb study A4001029

Clinical Microbiology and Infection (2014)

Matteo Surdo Claudia Alteri María C. Puertas Patrizia Saccomandi Lucia Parrotta

Maraviroc

CCR5 receptor antagonist

Sanger sequencing

10.1016/j.cmi.2014.08.002

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Citations (8)

Key genetic elements in HIV-1 gp120 V1,V2 and C4 domains tightly and differentially modulate gp120 interaction with the CCR5 and CXCR4 N terminus and HIV-1 antigenetic Potential

Valentina Svicher M. Chen Claudia Alteri Giosuè Costa Salvatore Dimonte

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HBsAg genetic elements critical for immune escape correlates with HBV reactivation upon immunosuppression

Digestive and Liver Disease (2014)

Romina Salpini Claudia Alteri Luna Colagrossi Maria Concetta Bellocchi Daniele Armenia

Immunosuppression

10.1016/j.dld.2014.01.027

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Citations (4)

Front & Back Matter

Intervirology (2012)

Fusheng Si Qian Yang Yumin Zhu Shijuan Dong Ruisong Yu

10.1159/000339535

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Peripheral and intrahepatic virological phenotyping in HBeAg negative Chronic Hepatitis B to evaluate risk of disease progression and HCC in the “grey-zone” viral load cohort: Can grey-zone patients be candidate to treatment?

Digestive and Liver Disease (2017)

Romina Salpini Luna Colagrossi A. Battisti N. Hansi Carlo Federico Perno

cccDNA

HBeAg

Liver disease

10.1016/j.dld.2017.01.017

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