Sadataka Inuzuka

Kyushu Central Hospital of the Mutual Aid Association of Public School Teachers

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Serum type III procollagen N paptide(PIIIP) and laminin levels and hepatic immunohistochemical study in patients with various liver diseases.

Kanzo (1989)

Takato Ueno Takuji Torimura Sadataka Inuzuka Kunihide Ishii Masao YOSHITAKE

各種肝疾患95例における血清タイプIIIプロコラーゲンNペプチド(PIIIP)やラミニン値の変動と肝生検組織における肝線維化,細胞浸潤および巣状壊死の程度,タイプIIIコラーゲンやラミニンの分布およびその産生細胞を観察し,さらに血清PIIIP,ラミニン値が肝線維化のマーカーになり得るか否かを検討した.血清PIIIPは活動性の肝病変を呈する疾患で高値を呈し,肝細胞障害に伴なうタイプIIIコラーゲンの形成を反映するものと思われた.また,血清ラミニンは肝線維化の高度な肝疾患例で高値を呈し,基底膜形成の増加をよく反映するものと思われ,血清PIIIPとラミニンを同時に測定することは,肝疾患の活動性,線維化の形成および程度の判定に有用と思われた.また,タイプIIIコラーゲンは伊東細胞,肝細胞,内皮細胞や線維芽細胞,ラミニンは内皮細胞,伊東細胞,肝細胞および胆管上皮細胞などにより産生されることが示唆された.

Procollagen peptidase

10.2957/kanzo.30.429

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Citations (1)

[A case of chronic intestinal pseudo-obstruction complicated by mucopolysaccharidosis I Scheie type].

PubMed (1986)

Sadataka Inuzuka Azusa Irie Ichirou IWAI Taro Matsuzaki Takeshi Emura

Mucopolysaccharidosis

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Citations (1)

Two Cases of Small Non-Polypoid Neoplasia in an Elongated Colonic Polyp

Endoscopy (2001)

Kazuoki Hizawa Toshihisa NAKAHARA Sadataka Inuzuka Kazutaka Akagi Ryuichi Shimono

Figure 1 Patient 1: colonoscopy shows a flabby potbelly-shaped pedunculated polyp (A) with a reddish and uneven head (B). The elongated polyp is composed of edematous submucosa and normal colonic mucosa (arrows), containing a depressed form of tubular adenoma (arrowheads)

Submucosa

Tubular adenoma

10.1055/s-2001-18931

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Citations (4)

Radiographic Evidence of Cholecystokinin Octapeptide Receptors in the Hamster Gallbladder

Scandinavian Journal of Gastroenterology (1991)

Takahiro Aoki Takato Ueno Atsushi Toyonaga Ryuichiro Sakata Y Kimura

The distribution of Cholecystokinin receptors in the hamster gallbladder was investigated by 125I-labeled Bolton-Hunter-cholecystokinin octapeptide autoradiography. Light microscopic examination showed a marked accumulation of radiolabeled Cholecystokinin within the domain of the muscle layer of the gallbladder. The electron microscopic study further disclosed the presence of radiolabeling mostly in those areas corresponding to cell-to-cell junctions of smooth-muscle cells. Our results suggest that contraction of the gallbladder may primarily be induced by cholecystokinin interacting with its specific receptor in smooth-muscle cells. That Cholecystokinin receptors were more abundant in the junctional complexes of smooth-muscle cells suggests that Cholecystokinin may have a major role in muscle contraction of the gallbladder, which eventually produces an effective bile emptying.

10.3109/00365529108998609

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Citations (10)

Distribution of substance P and vasoactive intestinal peptide in the human liver: light and electron immunoperoxidase methods of observation.

PubMed (1991)

Takato Ueno Sadataka Inuzuka Takuji Torimura Ryuichiro Sakata Masaharu Sakamoto

The localization of substance P (SP) and vasoactive intestinal peptide (VIP) in 12 normal human liver tissues was examined by light and electron immunohistochemistry using immunoperoxidase methods. SP and VIP immunoreactive nerve fibers were observed around portal veins, bile ducts, and hepatic arteries in portal areas, along sinusoids and hepatocytes in hepatic lobules, and around central veins. More SP and VIP immunoreactive nerve fibers were present in the portal areas than in other regions. Moreover, SP and VIP containing nerve endings were localized close to myofibroblasts, Ito cells, fibroblasts and endothelial cells of blood vessels, and sinusoids. The results suggested that part of the innervation of the human liver may be related to the contraction and relaxation of the cells close to nerve endings, and to the regulation of hemodynamic processes by the neurotransmitters such as SP and VIP at the hepatic lobular level.

Immunoperoxidase

Free nerve ending

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Citations (53)

A patient with hepatic granuloma formation and angiotensin‐converting enzyme production by granuloma cells during clinical relapse of hepatitis A

Pathology International (1994)

Sadataka Inuzuka Takato Ueno Hideo Tateishi Takuji Torimura Michio Sata

Elevation of the serum angiotensin‐converting enzyme (sACE) level and hepatic granulomas were found during a clinical relapse in a 22 year old patient with acute viral hepatitis type A (AVH‐A). The serum transaminase level and sACE level remained high for more than 6 months. In the biopsied specimen of the liver, fibrous rings of granulomas composed of collagen types I, III, and V were observed. Furthermore, the localization of ACE was visible in the rough endoplasmic reticulum of epithelioid cells of granulomas in the liver under electron microscopy using the indirect immunoperoxidase method. These results suggest that granuloma cells in the liver caused by hepatitis A may be involved in ACE production. In addition, other diseases associated with the presence of granulomas in the liver, such as lymphoma, cytomegalovirus infection, visceral leishmaniasis, and lupoid hepatitis, were ruled out. However, the hepatic granulomas disappeared with the healing of AVH‐A. In this regard, the present case is considered to be one of the very few cases of hepatic sarcoidosis.

Immunoperoxidase

10.1111/j.1440-1827.1994.tb02940.x

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Citations (3)

Transforming Growth Factorβ₁, Extracellular Matrix, and Inflammatory Cells in Wound Repair Using a Closed Duodenal Loop Pancreatitis Model Rat: Immunohistochemical Study

Scandinavian Journal of Gastroenterology (1995)

Y Kimura Takuji Torimura Takato Ueno Sadataka Inuzuka K Tanikawa

Serial changes in the localization of various components of extracellular matrix in acute pancreatitis have been reported, but there have been no reports on serial changes in the localization of transforming growth factor beta and the determination of cells producing extracellular matrix.In this study serial relationships between the localization of transforming growth factor beta 1, fibronectin and type-III collagen, inflammatory cells, and serum amylase levels in the process of tissue repair in acute pancreatitis were studied using a closed duodenal loop model rat. Furthermore, the cells producing transforming growth factor beta 1, fibronectin, and type-III collagen were investigated by immunoelectron microscopy.Three to 6 h after duodenal ligation slight localization of transforming growth factor beta 1 and fibronectin and inflammatory cell infiltration were observed in the interlobular space. Twelve to 24 h after duodenal ligation the infiltration of polymorphonuclear leukocytes and the deposition of transforming growth factor beta 1 and fibronectin were observed extensively in the interlobular and intralobular spaces. After release of the loop, infiltration of fibroblasts and marked deposition of fibronectin and type-III collagen were observed around the tubular complexes, but the deposition of transforming growth factor beta 1 was slight. Also, fibronectin and type-III collagen were shown to be produced by fibroblasts and acinar cells.These findings suggest that transforming growth factor beta 1 appears at the injured sites from the early stage of acute pancreatitis. Moreover, it is extensively related to the production of extracellular matrix such as fibronectin and type-III collagen. Furthermore, these substances are closely involved in the healing process of acute pancreatitis.

10.3109/00365529509096317

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Citations (18)

Distribution of intravenously injected secretin in the liver and its internalization into the bile epithelial cells.

Kanzo (1988)

Masao YOSHITAKE Shotaro Sakisaka Takato Ueno Kazunori Noguchi Yoshihiro IWAKI

セクレチンの肝臓での作用部位を明らかにするため,セクレチンを犬の末梢静脈より投与し,経時的に,セクレチンの肝臓での分布,標的細胞での動態を,抗セクレチン抗体を用い,光顕蛍光抗体法及び,光顕・電顕酵素抗体法により観察した.蛍光抗体法では,セクレチン投与3分後ですでに小葉内細胆管から門脈域隔壁胆管にいたるすべての大きさの肝内胆管のbasolateral側の細胞表面にセクレチンの蛍光を認め,大小を問わずすべての大きさの肝内胆管がセクレチンに対するreceptorを有すると考えられた.投与20分後ではlateral側の蛍光は弱くなり,luminal側の細胞表面にも蛍光を認めるようになった.光顕酵素抗体法では,セクレチン投与3分後では蛍光抗体法と同様の結果を得たが,20分後では細胞全体がdiffuseに染色された.電顕酵素抗体法では,20分後ではplasma membraneのみならず,ER,原形質内vesicleが染色された.

Secretin

Internalization

10.2957/kanzo.29.215

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Citations (2)

A Case of Mycoplasma Pneumonia, Complicated with an Autoimmune Cold Agglutinin hemolytic Anemia

Kansenshogaku zasshi (1986)

Sadataka Inuzuka K. Fukuhara Azusa Irie Ichirou IWAI Tatsunori Matsuzaki

A 16-year-old female infected with Mycoplasma pneumoniae developed pneumonia withautoimmune hemolytic anemia. During the acute phase of the illness, the patient developed Raynaud's symptom and acrocyanosis of the finger by cold exposure. A cold agglutinin titer of 131, 072 was found on the 12th day of hospitalization; the agglutinin was polyclonal IgM and predominantly blood group I-specific. The diagnosis of autoimmune hemolytic anemia, associated with Mycoplasma pneumoniae was made due to the marked elevation of cold agglutinin titers and anti-mycoplasma antibody titers. Both conditions responded promptly to erythromycin.

Cold Agglutinin

Mycoplasma pneumonia

Cold agglutinin disease

Polyclonal antibodies

10.11150/kansenshogakuzasshi1970.60.701

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Citations (0)

Cultured rat hepatic sinusoidal endothelial cells express intercellular adhesion molecule-1 (ICAM-1) by tumor necrosis factor-α or interleukin-1α stimulation

Journal of Hepatology (1994)

Hiromasa Ohira Takato Ueno Satoshi Shakado Masaharu Sakamoto Takuzi Torimura

Intercellular adhesion molecule

Immunoelectron microscopy

Cell–cell interaction

10.1016/s0168-8278(05)80142-4

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Citations (30)