To investigate the status of hearing intervention for old people with hearing loss.Through retrospective analyzing the data from 55 and up 55 years old people with hearing loss who received hearing intervention in five years (from 2000 - 2004) recently.There were 1008 person-times that received hearing examination within five years, 907 person-times speech frequency pure tone average (PTA) > 26 dB,there were only 73 people with hearing aid, and their speech frequency PTA > 55 dB.The hearing intervention situation for old people isn't perfect. It needs audiologists cooperate with the family of old people, the whole society and the old people themselves to help them in hearing and improve their quality of life.
Traditional Chinese medicine (TCM) or combined with western medicine in the treatment of pediatric adenoidal hypertrophy has been widely used in clinical practice, but the overall efficacy and safety is still unclear. This paper aims to evaluate the efficacy and safety analysis of TCM or combined with western medicine for pediatric adenoidal hypertrophy.
OBJECTIVE: To investigate the features of nasolacrimal duct MALT (mucosa-associated lymphoid tissue), and to explore the aetiology of chronic dacryocystitis. METHOD: The mucous of nasolacrimal duct, nasal cavity, pharyngeal and trachea of 20 rabbits were studied, and the lymphoid tissue and HEV of them were compared. RESULT: The number of lymphoid follicle and HEV in nasolacrimal duct epidermis were less than that in nasal cavity, pharyngeal and trachea (P<0.01). CONCLUSION: In normal condition the immune response of nasolacrimal duct membranae is lower than other mucosa of head-neck.
OBJECTIVE To investigate the effect of small interfering RNA (siRNA) targeting c-myc gene in Hep-2 cells. METHOD siRNA targeting c-myc mRNA was designed and synthesized. In vitro cultured Hep-2 cells were transfected with lipofectamine 2000 and the inhibitory effect was detected by MTT, morphology, real time PCR assay. RESULT 1) The MTT result showed the c-myc siRNA to be able effectively to suppress the Hep-2 cell multiplication; 2) The real time PCR result showed c-myc at mRNA level inhibition ratio at 94% in group S3; 3) The morphology result showed the c-myc siRNA to be able effectively to suppress the Hep-2 cell multiplication, the cell heteromorphism was diminished. CONCLUSION siRNA targeting c-myc can remarkably suppress the Hep-2 cell growth and multiplication.
Purpose: Reports the clinical data and ADAT3 gene mutation of a 2-year-old child to improve clinicians' understanding of autosomal recessive mental retardation type 36. Results: The patient have two heterozygous mutations in ADAT3 gene and was diagnosed as automotive received mental retention type 36. Conclusions: Autosomal recessive intellectual disability type 36 was associated with two complex heterozygous mutations in the ADAT3 gene, involving c.219dupA（p.R74Tfs*51）and c.587C>T（p.A196V）
To explore the eye complication of nasopharyngeal carcinoma (NPC), to analysis the clinical manifestation, CT characteristics and pathological diagnosis of eye complications of NPC and to provide the base for early diagnosis of NPC.To retrospectively study of 82 cases eye complications in 562 cases NPC, to study their clinical manifestation, CT characteristics and pathological diagnosis.The clinical studies showed that eye complication cases were occurred in 82 cases of 562 NPC cases (14.6%). Thirty-six cases in left and 37 cases in right eye, 9 cases in bilateral eyes. Sixty-five cases came from Guangdong, while the others 17 cases come from 5 provinces. There were 9 kinds of eye manifestation. CT appearances: 40 cases suffered from skull base distracted, 6 cases with orbit involved, 2 cases ( in left eyes) with orbit metastasis, 12 cases with nose-sinus involved, 68 case with parapharyngeal space involved, 49 cases with soft issue in wall of styloid process involved (there were many kind of shows in the same case, so the data were repeated in these cases).There were multiplicity and complexity in eye complication of NPC. Ophthalmologists should think highly of these cases.
To investigate the expression and the clinical significance of proto-oncogene cerbB-2 proteins p185 and adhesion molecules CD44v6 in laryngeal squamous cell carcinomas (LSCC) and the relationship between them.expression of p185 and CD44v6 was studied by immunohistochemical analysis from 63 cases of LSCC, 20 cases of adjacent safety margin (ASM) and 18 cases of vocal cord polyp(VCP).There were no expression of p185in VCP, Significant differences (P < 0.05) were observed between the two group; there was significant differences among the different pathologic degree I, II, III; The expression of p185 was not related to age and clinical stage. Significant differences (P < 0.05) were found among LSCC, VCP and ASM; there was no differences between the different pathologic degree I, II, III. The expression of CD44v6 was not related to age and clinical stage. Significant correlation was observed between the expression of p185 and CD44v6 in LSCC.p185 probably plays an important role during the carcinogenesis and progression process of LSCC. While CD44v6 has the important function only in the carcinogenesis process of LSCC. The expression of p185 and CD44v6 were higher in ASM than in VCP. It indicates that p185 and CD44v6 were probably the unstable factor in ASM which related to the recurrent of laryngeal carcinoma, and they may cooperate with each other.
To investigate the molecular difference and significance between the primary foci and metastases foci of laryngeal squamous cell carcinoma (LSCC).Tissues of 18 cases of positive lymph node metastases (N+) LSCC were detected by using SP method. The LSCC primary foci and metastases foci and negative metastases lymph nodes were included, 22 cases of vocal cord polyp (VCP) were regarded as control. expression of PTEN and Survivin were evaluated by SP immunohistochemistry.Expression of neither PTEN nor Survivin were positive in negative nodes. The positive rates of PTEN in LSCC, N+, VCP were 94.4% (17/18), 94.4% (17/18) and 95.5% (21/22) respectively, there were no significant difference among them (P>0.05). But the expression degree were more powerful in N+ than in the LSCC (P<0.05). There was no expression of Survivin in VCP. The positive rates of Survivin in LSCC and N+ were 55.5% (10/18), 50.0% (9/18), the difference were significant (P<0.01); but between LSCC and N+, neither the positive rate nor the expression degree had significant difference (P>0.05).There were differences between the LSCC primary foci and the lymph node metastases foci in molecular level probably.
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