Rhomes J. A. Aur

May Institute

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H. Omar Hustu

St. Jude Children's Research Hospital

Joseph V. Simone

New York Institute of Technology

Manuel S. Verzosa

St. Jude Children's Research Hospital

Donald Pinkel

St. Jude Children's Research Hospital

Rajeh Sabbah

King Faisal Specialist Hospital & Research Centre

Kwesi Sackey

King Faisal Specialist Hospital & Research Centre

Gaston K. Rivera

St. Jude Children's Research Hospital

Charles B. Pratt

Children's Research Hospital

Gary V. Dahl

Stanford University

J. V. Simone

Experimental Medicine and Biology Institute

Cooperative Institutions

St. Jude Children's Research Hospital

King Faisal Specialist Hospital & Research Centre

University of Tennessee Health Science Center

University of Tennessee at Knoxville

May Institute

Boston Children's Hospital

St Bartholomew's Hospital

Cornell University

Southampton General Hospital

University of Sheffield

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Intensity of immunosuppressive therapy and the incidence of pneumocystis carinii pneumonitis

Cancer (1975)

Walter T. Hughes Sandor Feldman Rhomes J. A. Aur Manuel S. Verzosa H. Omar Hustu

Abstract One hundred and forty‐nine children with acute lymphocytic leukemia treated according to a prospective protocol were randomized after induction of remission and central nervous system (CNS) irradiation to receive maintenance chemotherapy with 1, 2, 3, or 4 chemotherapy agents. The incidence of P. carinii pneumonitis (PCP) was 5.0, 2.3, 2.2, and 22.4%, respectively, during the period of maintenance therapy. An additional 31 patients enrolled in the same study were placed in special categories to receive three drugs for maintenance plus supplemental chemotherapy or irradiation because of CNS leukemia on admission, remission failure, mediastinal mass, or generalized lymphosarcoma without bone marrow involvement. The incidences of PCP in these groups were 16.7, 30.0, 35.7, and 0%, respectively, during the period of maintenance therapy.

Pneumonitis

Maintenance therapy

10.1002/cncr.2820360612

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Citations (15)

Relevance of Treating Childhood Acute Leukemias

Annals of Saudi Medicine (1988)

Rhomes J. A. Aur

Relevance

Childhood Cancer

10.5144/0256-4947.1988.2

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Citations (1)

Central Nervous System Leukemia

Rhomes J. A. Aur H. Omar Hustu Manuel S. Verzosa Joseph V. Simone

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Citations (0)

Immunophenotypic and age patterns of childhood acute lymphoblastic leukemia in Saudi Arabia

Leukemia Research (1990)

George T. Roberts Rhomes J. A. Aur Kirtikant V. Sheth

Immunophenotyping

Age groups

10.1016/0145-2126(90)90023-3

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Citations (15)

Five years after central nervous system irradiation of children with leukemia

International Journal of Radiation Oncology*Biology*Physics (1976)

Manuel S. Verzosa Rhomes J. A. Aur Joseph V. Simone H. Omar Hustu Donald Pinkel

10.1016/0360-3016(76)90042-0

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Citations (77)

Burkitt's Lymphoma in Saudi Arabia: Clinical, Pathological, and Epidemiological Analyses of 16 Cases

Annals of Saudi Medicine (1982)

Rajih S. Sabbah M. Ashraf Ali David B. Lewall Rhomes J. A. Aur

10.5144/0256-4947.1982.77

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Citations (7)

Prevention of central nervous system leukemia by irradiation

Cancer (1973)

H. Omar Hustu Rhomes J. A. Aur Manuel S. Verzosa J. V. Simone Donald Pinkel

During the past 10 years, 1962 to 1972, we have administered irradiation to the central nervous system (CNS) during the first few weeks of remission of acute lymphocytic leukemia (ALL) as an integral part of a treatment plan aimed at cure of ALL. Its purpose has been to eradicate residual leukemia in the CNS and thus prevent CNS relapse. The results indicate that craniospinal irradiation alone, 2400 rads, or cranial irradiation, 2400 rads, with simultaneous intrathecal methotrexate is effective in -preventing CNS relapse. This results in marked improvement in complete remission duration and a 50% frequency of long-term leukemia-free survival and possible cure. Although intermittent intrathecal methotrexate during remission is said to reduce the incidence of CNS relapse by one half, a 15-fold reduction results from adequate preventive CNS irradiation. Until a better method is found, all children with ALL should receive adequate CNS irradiation early during remission in order to prevent CNS relapse and to prolong complete remission.

Prophylactic cranial irradiation

Acute lymphocytic leukemia

10.1002/1097-0142(197309)32:3<585::aid-cncr2820320311>3.0.co;2-k

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Citations (217)

Successful Chemoprophylaxis forPneumocystis cariniiPneumonitis

New England Journal of Medicine (1977)

Walter T. Hughes Shirley Kuhn Subhash Chaudhary Sandor Feldman Manuel S. Verzosa

In a randomized, double-blind, placebo-controlled study to evaluate the efficacy of trimethoprim–sulfamethoxazole for the prevention of Pneumocystis carinii pneumonia, we studied 160 patients with cancer who were at high risk for this pneumonia over a two-year period. Seventeen of the 80 patients receiving a placebo acquired P. carinii pneumonitis, whereas none of the 80 given 150 mg of trimethoprim and 750 mg of sulfamethoxazole per square meter per day had the infection (P<0.01). Bacterial sepsis, pneumonia other than that caused by P. carinii, acute otitis media, upper-respiratory-tract infections, sinusitis and cellulitis occurred less frequently in recipients of the drug than in the placebo group (P<0.01 in each case). Oral candidiasis was the only adverse effect encountered from trimethoprim–sulfamethoxazole administration. The study shows the combination to be highly effective in the prevention of P. carinii pneumonitis. (N Engl J Med 297:1419–1426, 1977)

Trimethoprim

Pneumonitis

Sulfamethoxazole

Chemoprophylaxis

10.1056/nejm197712292972602

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Citations (694)

Surgical treatment of bilateral synchronous wilms' tumors

Journal of Surgical Oncology (1987)

Kamal A. Hanash Kwesi Sackey Rajeh Sabbah Mohammed Akhtar Rhomes J. A. Aur

Definite progress has been made in the treatment of bilateral Wilms' tumors with marked improvement in the prognosis. This is confirmed in our series of 6 consecutive patients with synchronous tumors. The recent trend toward more conservative surgery, double or triple drug chemotherapy, and avoidance of high-dose radiation therapy has yielded good results.

Conservative Treatment

Wilms tumour

Surgical excision

10.1002/jso.2930340308

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Citations (5)

Orbital granulocytic sarcoma.

American Journal of Neuroradiology (1991)

Mohamed Banna Rhomes J. A. Aur Salah Akkad

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Citations (22)